Histone deacetylases as regulators of inflammation and immunity MR Shakespear, MA Halili, KM Irvine, DP Fairlie, MJ Sweet Trends in immunology 32 (7), 335-343, 2011 | 570 | 2011 |
Histone deacetylase inhibitors in inflammatory disease MA Halili, MR Andrews, MJ Sweet, DP Fairlie Current topics in medicinal chemistry 9 (3), 309-319, 2009 | 233 | 2009 |
Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS MA Halili, MR Andrews, LI Labzin, K Schroder, G Matthias, C Cao, ... Journal of leukocyte biology 87 (6), 1103-1114, 2010 | 225 | 2010 |
Antifibrotic activity of an inhibitor of histone deacetylases in DOCA‐salt hypertensive rats A Iyer, A Fenning, J Lim, GT Le, RC Reid, MA Halili, DP Fairlie, L Brown British journal of pharmacology 159 (7), 1408-1417, 2010 | 155 | 2010 |
Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110) JY Suen, GD Barry, RJ Lohman, MA Halili, AJ Cotterell, GT Le, DP Fairlie British journal of pharmacology 165 (5), 1413-1423, 2012 | 128 | 2012 |
Disarming Burkholderia pseudomallei: Structural and Functional Characterization of a Disulfide Oxidoreductase (DsbA) Required for Virulence In Vivo PM Ireland, RM McMahon, LE Marshall, M Halili, E Furlong, S Tay, ... Antioxidants & redox signaling 20 (4), 606-617, 2014 | 55 | 2014 |
Peptide Inhibitors of the Escherichia coli DsbA Oxidative Machinery Essential for Bacterial Virulence W Duprez, L Premkumar, MA Halili, F Lindahl, RC Reid, DP Fairlie, ... Journal of medicinal chemistry 58 (2), 577-587, 2015 | 50 | 2015 |
Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like … L Premkumar, B Heras, W Duprez, P Walden, M Halili, F Kurth, DP Fairlie, ... Acta Crystallographica Section D: Biological Crystallography 69 (10), 1981-1994, 2013 | 40 | 2013 |
Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a RJ Lohman, JK Hamidon, RC Reid, JA Rowley, MK Yau, MA Halili, ... Nature communications 8 (1), 351, 2017 | 36 | 2017 |
Small molecule inhibitors of disulfide bond formation by the bacterial DsbA–DsbB dual enzyme system MA Halili, P Bachu, F Lindahl, C Bechara, B Mohanty, RC Reid, ... ACS chemical biology 10 (4), 957-964, 2015 | 32 | 2015 |
Comparative sequence, structure and redox analyses of Klebsiella pneumoniae DsbA show that anti-virulence target DsbA enzymes fall into distinct classes F Kurth, K Rimmer, L Premkumar, B Mohanty, W Duprez, MA Halili, ... PloS one 8 (11), e80210, 2013 | 30 | 2013 |
A refined agonist pharmacophore for protease activated receptor 2 GD Barry, JY Suen, HB Low, B Pfeiffer, B Flanagan, M Halili, GT Le, ... Bioorganic & medicinal chemistry letters 17 (20), 5552-5557, 2007 | 24 | 2007 |
A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance EJ Furlong, AW Lo, F Kurth, L Premkumar, M Totsika, MES Achard, ... Nature communications 8 (1), 16065, 2017 | 23 | 2017 |
The 1.2 Å resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production PM Walden, B Heras, KE Chen, MA Halili, K Rimmer, P Sharma, ... Acta Crystallographica Section D: Biological Crystallography 68 (10), 1290-1302, 2012 | 21 | 2012 |
Potent thiophene antagonists of human complement C3a receptor with anti-inflammatory activity JA Rowley, RC Reid, EKY Poon, KC Wu, J Lim, RJ Lohman, JK Hamidon, ... Journal of Medicinal Chemistry 63 (2), 529-541, 2020 | 20 | 2020 |
Noncovalent tripeptidyl benzyl-and cyclohexyl-amine inhibitors of the cysteine protease caspase-1 R Löser, G Abbenante, PK Madala, M Halili, GT Le, DP Fairlie Journal of medicinal chemistry 53 (6), 2651-2655, 2010 | 20 | 2010 |
Structure− Activity Relationships for Substrate-Based Inhibitors of Human Complement Factor B G Ruiz-Gómez, J Lim, MA Halili, GT Le, PK Madala, G Abbenante, ... Journal of medicinal chemistry 52 (19), 6042-6052, 2009 | 16 | 2009 |
Structure of the Acinetobacter baumannii dithiol oxidase DsbA bound to elongation factor EF-Tu reveals a novel protein interaction site L Premkumar, F Kurth, W Duprez, MK Grøftehauge, GJ King, MA Halili, ... Journal of Biological Chemistry 289 (29), 19869-19880, 2014 | 15 | 2014 |
The α-proteobacteria Wolbachia pipientis protein disulfide machinery has a regulatory mechanism absent in γ-proteobacteria PM Walden, MA Halili, JK Archbold, F Lindahl, DP Fairlie, K Inaba, ... PLoS One 8 (11), e81440, 2013 | 13 | 2013 |
Complement component C2, inhibiting a latent serine protease in the classical pathway of complement activation MA Halili, G Ruiz-Gomez, GT Le, G Abbenante, DP Fairlie Biochemistry 48 (35), 8466-8472, 2009 | 12 | 2009 |