| Insights into Editing from an Ile-tRNA Synthetase Structure with tRNAIle and Mupirocin LF Silvian, J Wang, TA Steitz Science 285 (5430), 1074-1077, 1999 | 537 | 1999 |
| Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism D Marcotte, W Zeng, JC Hus, A McKenzie, C Hession, P Jin, C Bergeron, ... Bioorganic & medicinal chemistry 21 (14), 4011-4019, 2013 | 241 | 2013 |
| Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus LF Silvian, EA Toth, P Pham, MF Goodman, T Ellenberger Nature structural biology 8 (11), 984-989, 2001 | 235 | 2001 |
| Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site M Rushe, L Silvian, S Bixler, LL Chen, A Cheung, S Bowes, H Cuervo, ... Structure 16 (5), 798-808, 2008 | 183 | 2008 |
| How glutaminyl-tRNA synthetase selects glutamine VL Rath, LF Silvian, B Beijer, BS Sproat, TA Steitz Structure 6 (4), 439-449, 1998 | 175 | 1998 |
| Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases DJ Marcotte, YT Liu, RM Arduini, CA Hession, K Miatkowski, CP Wildes, ... Protein Science 19 (3), 429-439, 2010 | 162 | 2010 |
| A neutralizing anti-Nogo66 receptor monoclonal antibody reverses inhibition of neurite outgrowth by central nervous system myelin W Li, L Walus, SA Rabacchi, A Jirik, E Chang, J Schauer, BH Zheng, ... Journal of Biological Chemistry 279 (42), 43780-43788, 2004 | 114 | 2004 |
| Improving the solubility of anti‐LINGO‐1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis RB Pepinsky, L Silvian, SA Berkowitz, G Farrington, A Lugovskoy, ... Protein Science 19 (5), 954-966, 2010 | 113 | 2010 |
| Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor family member BAFF (B cell activating factor) TG Cachero, IM Schwartz, F Qian, ES Day, C Bossen, K Ingold, A Tardivel, ... Biochemistry 45 (7), 2006-2013, 2006 | 105 | 2006 |
| Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery DA Erlanson, JW Arndt, MT Cancilla, K Cao, RA Elling, N English, ... Bioorganic & medicinal chemistry letters 21 (10), 3078-3083, 2011 | 95 | 2011 |
| Artemin crystal structure reveals insights into heparan sulfate binding L Silvian, P Jin, P Carmillo, PA Boriack-Sjodin, C Pelletier, M Rushe, ... Biochemistry 45 (22), 6801-6812, 2006 | 81 | 2006 |
| Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanism LF Silvian, JE Friedman, K Strauch, TG Cachero, ES Day, F Qian, ... ACS chemical biology 6 (6), 636-647, 2011 | 63 | 2011 |
| Bruton's tyrosine kinase inhibitors M Bui, P Conlon, JH Cuervo, DA Erlanson, FAN Junfa, B Guan, ... US Patent 8,785,440, 2014 | 43 | 2014 |
| New approaches for the treatment of pain: the GDNF family of neurotrophic growth factors DWY Sah, MH Ossipov, A Rossomando, L Silvian, F Porreca Current topics in medicinal chemistry 5 (6), 577-583, 2005 | 43 | 2005 |
| Synthesis, SAR and biological evaluation of 1, 6-disubstituted-1H-pyrazolo [3, 4-d] pyrimidines as dual inhibitors of Aurora kinases and CDK1 JY Le Brazidec, A Pasis, B Tam, C Boykin, C Black, D Wang, G Claassen, ... Bioorganic & medicinal chemistry letters 22 (5), 2070-2074, 2012 | 41 | 2012 |
| Discovery of biaryl carboxylamides as potent RORγ inverse agonists J Chao, I Enyedy, K Van Vloten, D Marcotte, K Guertin, R Hutchings, ... Bioorganic & Medicinal Chemistry Letters 25 (15), 2991-2997, 2015 | 37 | 2015 |
| ATP-competitive MLKL binders have no functional impact on necroptosis B Ma, D Marcotte, M Paramasivam, K Michelsen, T Wang, ... PLoS One 11 (11), e0165983, 2016 | 33 | 2016 |
| Nogo receptor antagonists DHS Lee, D Wen, RB Pepinsky, JK Relton, X Wang, A Lugovskoy, ... US Patent 8,669,345, 2014 | 33 | 2014 |
| Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand DJ Marcotte, YT Liu, K Little, JH Jones, NA Powell, CP Wildes, LF Silvian, ... BMC Structural Biology 16, 1-9, 2016 | 29 | 2016 |
| Structure-based design of 2, 6, 7-trisubstituted-7H-pyrrolo [2, 3-d] pyrimidines as Aurora kinases inhibitors JY Le Brazidec, A Pasis, B Tam, C Boykin, D Wang, DJ Marcotte, ... Bioorganic & medicinal chemistry letters 22 (12), 4033-4037, 2012 | 28 | 2012 |
