A naturally inspired antibiotic to target multidrug-resistant pathogens Z Wang, B Koirala, Y Hernandez, M Zimmerman, S Park, DS Perlin, ... Nature 601 (7894), 606-611, 2022 | 150 | 2022 |
Bioinformatic prospecting and synthesis of a bifunctional lipopeptide antibiotic that evades resistance Z Wang, B Koirala, Y Hernandez, M Zimmerman, SF Brady Science 376 (6596), 991-996, 2022 | 70 | 2022 |
Structure–Activity Relationships of the Competence Stimulating Peptides (CSPs) in Streptococcus pneumoniae Reveal Motifs Critical for Intra-group and Cross … Y Yang, B Koirala, LA Sanchez, NR Phillips, SR Hamry, Y Tal-Gan ACS chemical biology 12 (4), 1141-1151, 2017 | 55 | 2017 |
Synthetic-bioinformatic natural product antibiotics with diverse modes of action J Chu, B Koirala, N Forelli, X Vila-Farres, MA Ternei, T Ali, DA Colosimo, ... Journal of the American Chemical Society 142 (33), 14158-14168, 2020 | 46 | 2020 |
Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens L Li, B Koirala, Y Hernandez, LW MacIntyre, MA Ternei, R Russo, ... Nature microbiology 7 (1), 120-131, 2022 | 37 | 2022 |
Development of a Dominant Negative Competence‐Stimulating Peptide (dnCSP) that Attenuates Streptococcus pneumoniae Infectivity in a Mouse Model of Acute … B Koirala, J Lin, GW Lau, Y Tal‐Gan ChemBioChem 19 (22), 2380-2386, 2018 | 27 | 2018 |
Biosynthetic Interrogation of Soil Metagenomes Reveals Metamarin, an Uncommon Cyclomarin Congener with Activity against Mycobacterium tuberculosis L Li, LW MacIntyre, T Ali, R Russo, B Koirala, Y Hernandez, SF Brady Journal of natural products 84 (4), 1056-1066, 2021 | 23 | 2021 |
Metabolites with SARS-CoV-2 inhibitory activity identified from human microbiome commensals FJ Piscotta, HH Hoffmann, YJ Choi, GI Small, AW Ashbrook, B Koirala, ... Msphere 6 (6), e00711-21, 2021 | 16 | 2021 |
Unveiling the Importance of Amide Protons in CSP:ComD Interactions in Streptococcus pneumoniae B Koirala, NR Phillips, Y Tal-Gan ACS Medicinal Chemistry Letters 10 (6), 880-886, 2019 | 13 | 2019 |
Defining the hydrophobic interactions that drive competence stimulating peptide (CSP)-ComD binding in Streptococcus pneumoniae B Koirala, RA Hillman, EK Tiwold, MA Bertucci, Y Tal-Gan Beilstein journal of organic chemistry 14 (1), 1769-1777, 2018 | 12 | 2018 |
Development of Streptococcus pneumoniae Pan‐Group Quorum‐Sensing Modulators B Koirala, Y Tal‐Gan ChemBioChem 21 (3), 340-345, 2020 | 11 | 2020 |
Harnessing Multiple, Nonproteogenic Substitutions to Optimize CSP:ComD Hydrophobic Interactions in Group 1 Streptococcus pneumoniae TA Milly, ER Engler, KS Chichura, AR Buttner, B Koirala, Y Tal‐Gan, ... ChemBioChem 22 (11), 1940-1947, 2021 | 10 | 2021 |
Discovery of Paenibacillaceae family Gram-negative-active cationic lipopeptide antibiotics using evolution-guided chemical synthesis Z Wang, B Koirala, Y Hernandez, SF Brady Organic letters 24 (27), 4943-4948, 2022 | 8 | 2022 |
Synthesis and evaluation of dual-action kanglemycin-fluoroquinolone hybrid antibiotics J Peek, B Koirala, SF Brady Bioorganic & medicinal chemistry letters 57, 128484, 2022 | 7 | 2022 |
Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome Commensals. mSphere. 2021: e0071121 FJ Piscotta, HH Hoffmann, YJ Choi, GI Small, AW Ashbrook, B Koirala, ... Epub 2021/12/02. https://doi. org/10.1128/mSphere. 00711-21 PMID: 34851166, 0 | 5 | |
Cinnamosyn, a Cinnamoylated Synthetic-Bioinformatic Natural Product with Cytotoxic Activity LW MacIntyre, B Koirala, A Rosenzweig, A Morales-Amador, SF Brady Organic Letters, 2024 | 1 | 2024 |
Front Cover: Development of Streptococcus pneumoniae Pan‐Group Quorum‐Sensing Modulators (ChemBioChem 3/2020) B Koirala, Y Tal‐Gan ChemBioChem 21 (3), 279-279, 2020 | | 2020 |
Development of Peptide-Based Probes to Target Quorum Sensing in Streptococcus pneumoniae B Koirala | | 2019 |
Effects of multiple amino acid mutations of a key quorum sensing peptide, CSP-1 K Chichura, B Koirala, Y Tal-Gana, M Bertucci ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256, 2018 | | 2018 |
Remodeling the hydrophobic face of CSP-1, a peptide autoinducer for quorum sensing in Streptococcus pneumoniae R Hillman, E Tiwold, B Koirala, Y Tal-Gan, M Bertucci ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256, 2018 | | 2018 |