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Tiernan T. O'Malley
Tiernan T. O'Malley
Director, Head of Human Biology and Data Science
在 eisai.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes
S Hong, BL Ostaszewski, T Yang, TT O’Malley, M Jin, K Yanagisawa, S Li, ...
Neuron 82 (2), 308-319, 2014
2332014
mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo
NW Hu, AJ Nicoll, D Zhang, AJ Mably, T O’Malley, SA Purro, C Terry, ...
Nature communications 5 (1), 3374, 2014
2072014
C-terminally truncated forms of tau, but not full-length tau or its C-terminal fragments, are released from neurons independently of cell death
D Kanmert, A Cantlon, CR Muratore, M Jin, TT O'Malley, G Lee, ...
Journal of Neuroscience 35 (30), 10851-10865, 2015
1752015
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, ...
Nature structural & molecular biology 27 (12), 1125-1133, 2020
1582020
Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance
M Lei, H Xu, Z Li, Z Wang, TT O'Malley, D Zhang, DM Walsh, P Xu, ...
Neurobiology of disease 85, 111-121, 2016
1582016
Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier
J Keaney, DM Walsh, T O’Malley, N Hudson, DE Crosbie, T Loftus, ...
Science advances 1 (8), e1500472, 2015
1512015
APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapses
H Fogel, S Frere, O Segev, S Bharill, I Shapira, N Gazit, T O’Malley, ...
Cell reports 7 (5), 1560-1576, 2014
1442014
Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity
AJ Nicoll, S Panico, DB Freir, D Wright, C Terry, E Risse, CE Herron, ...
Nature communications 4 (1), 2416, 2013
1422013
New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF
T Yang, S Hong, T O'Malley, RA Sperling, DM Walsh, DJ Selkoe
Alzheimer's & Dementia 9 (2), 99-112, 2013
1292013
Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain
W Hong, Z Wang, W Liu, TT O’Malley, M Jin, M Willem, C Haass, ...
Acta neuropathologica 136, 19-40, 2018
1242018
A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid
T Yang, TT O’Malley, D Kanmert, J Jerecic, LR Zieske, H Zetterberg, ...
Alzheimer's research & therapy 7, 1-16, 2015
992015
Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer’s brain
G Brinkmalm, W Hong, Z Wang, W Liu, TT O’Malley, X Sun, MP Frosch, ...
Brain 142 (5), 1441-1457, 2019
942019
Extracellular forms of Aβ and tau from iPSC models of Alzheimer’s disease disrupt synaptic plasticity
NW Hu, GT Corbett, S Moore, I Klyubin, TT O’Malley, DM Walsh, ...
Cell Reports 23 (7), 1932-1938, 2018
852018
Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies
TT O’Malley, NA Oktaviani, D Zhang, A Lomakin, B O’Nuallain, S Linse, ...
Biochemical Journal 461 (3), 413-426, 2014
752014
An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease
M Jin, B O’Nuallain, W Hong, J Boyd, VN Lagomarsino, TT O’Malley, ...
Nature communications 9 (1), 2676, 2018
592018
The aqueous phase of Alzheimer's disease brain contains assemblies built from∼ 4 and∼ 7 kDa Aβ species
JM Mc Donald, TT O'Malley, W Liu, AJ Mably, G Brinkmalm, E Portelius, ...
Alzheimer's & Dementia 11 (11), 1286-1305, 2015
592015
Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid‐β Aggregates
CN Loynachan, G Romero, MG Christiansen, R Chen, R Ellison, ...
Advanced Healthcare Materials 4 (14), 2100-2109, 2015
302015
The aggregation paths and products of Aβ42 dimers are distinct from those of the Aβ42 monomer
TT O’Malley, WM Witbold III, S Linse, DM Walsh
Biochemistry 55 (44), 6150-6161, 2016
232016
Kinetic fingerprints differentiate anti-Aβ therapies
S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, ...
bioRxiv, 815308, 2020
8*2020
IgG Conformer's binding to amyloidogenic aggregates
M Phay, AT Welzel, AD Williams, HP McWilliams-Koeppen, V Blinder, ...
PloS one 10 (9), e0137344, 2015
82015
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