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| Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing JE Neggers, T Vercruysse, M Jacquemyn, E Vanstreels, E Baloglu, ... Chemistry & biology 22 (1), 107-116, 2015 | 147 | 2015 |
| Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes JE Neggers, B Kwanten, T Dierckx, H Noguchi, A Voet, L Bral, K Minner, ... Nature Communications 9 (1), 502, 2018 | 112 | 2018 |
| The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia T Vercruysse, J De Bie, JE Neggers, M Jacquemyn, E Vanstreels, ... Clinical Cancer Research 23 (10), 2528-2541, 2017 | 62 | 2017 |
| TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry J Baggen, M Jacquemyn, L Persoons, E Vanstreels, VE Pye, AG Wrobel, ... Cell 186 (16), 3427-3442. e22, 2023 | 50 | 2023 |
| The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems K Lasker, S Boeynaems, V Lam, D Scholl, E Stainton, A Briner, ... Nature Communications 13 (1), 5643, 2022 | 50 | 2022 |
| ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization GHP Tazelaar, S Boeynaems, M De Decker, JJFA van Vugt, L Kool, ... Brain communications 2 (2), fcaa064, 2020 | 50 | 2020 |
| Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas N Saenz-Ponce, R Pillay, LM de Long, T Kashyap, C Argueta, ... Science translational medicine 10 (447), eaar7223, 2018 | 39 | 2018 |
| STK 38 kinase acts as XPO 1 gatekeeper regulating the nuclear export of autophagy proteins and other cargoes APJ Martin, M Jacquemyn, J Lipecka, C Chhuon, VN Aushev, B Meunier, ... EMBO reports 20 (11), e48150, 2019 | 38 | 2019 |
| Human exportin-1 is a target for combined therapy of HIV and AIDS related lymphoma E Boons, E Vanstreels, M Jacquemyn, TC Nogueira, JE Neggers, ... EBioMedicine 2 (9), 1102-1113, 2015 | 32 | 2015 |
| A modular platform for engineering function of natural and synthetic biomolecular condensates K Lasker, S Boeynaems, V Lam, E Stainton, M Jacquemyn, D Daelemans, ... BioRxiv, 2021.02. 03.429226, 2021 | 24 | 2021 |
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| CRISPR/Cas9 screen in human iPSC‐derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity W Guo, H Wang, A Kumar Tharkeshwar, J Couthouis, E Braems, ... Alzheimer's & Dementia 19 (4), 1245-1259, 2023 | 14 | 2023 |
| enAsCas12a enables CRISPR-directed evolution to screen for functional drug resistance mutations in sequences inaccessible to SpCas9 JE Neggers, M Jacquemyn, T Dierckx, BP Kleinstiver, HJ Thibaut, ... Molecular Therapy 29 (1), 208-224, 2021 | 11 | 2021 |
| CRISPR-Cas9 recognition of enzymatically synthesized base-modified nucleic acids H Yang, E Eremeeva, M Abramov, M Jacquemyn, E Groaz, D Daelemans, ... Nucleic Acids Research 51 (4), 1501-1511, 2023 | 9 | 2023 |
| XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53-mediated caspase-dependent apoptosis E Boons, TC Nogueira, T Dierckx, SM Menezes, M Jacquemyn, S Tamir, ... Blood cancer journal 11 (2), 27, 2021 | 7 | 2021 |
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| Selective Inhibitors of Nuclear Export (SINE) Compounds Suppress Both HIV Replication and AIDS Related Lymphoma D Daelemans, E Boons, E Vanstreels, M Jacquemyn, TC Nogueira, ... Blood, The Journal of the American Society of Hematology 126 (23), 2751-2751, 2015 | 1 | 2015 |
| Aberrant N-glycosylation in pathogenic variants of adenosine deaminase 2 underlying human ADA2 deficiency L Ehlers, A Hombrouck, M Wouters, B Pillay, S Delafontaine, G Bucciol, ... | | 2023 |
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