| 3DM: systematic analysis of heterogeneous superfamily data to discover protein functionalities RK Kuipers, HJ Joosten, WJH Van Berkel, NGH Leferink, E Rooijen, ... Proteins: Structure, Function, and Bioinformatics 78 (9), 2101-2113, 2010 | 198 | 2010 |
| The growing VAO flavoprotein family NGH Leferink, DPHM Heuts, MW Fraaije, WJH van Berkel Archives of biochemistry and biophysics 474 (2), 292-301, 2008 | 146 | 2008 |
| l‐Galactono‐γ‐lactone dehydrogenase from Arabidopsis thaliana, a flavoprotein involved in vitamin C biosynthesis NGH Leferink, WAM van den Berg, WJH van Berkel The FEBS journal 275 (4), 713-726, 2008 | 119 | 2008 |
| Identification of a Gatekeeper Residue That Prevents Dehydrogenases from Acting as Oxidases*♦ NGH Leferink, MW Fraaije, HJ Joosten, PJ Schaap, A Mattevi, ... Journal of Biological Chemistry 284 (7), 4392-4397, 2009 | 104 | 2009 |
| Correlated mutation analyses on super‐family alignments reveal functionally important residues RKP Kuipers, HJ Joosten, E Verwiel, S Paans, J Akerboom, ... Proteins: Structure, Function, and Bioinformatics 76 (3), 608-616, 2009 | 94 | 2009 |
| Occurrence and biocatalytic potential of carbohydrate oxidases EW van Hellemond, NGH Leferink, DPHM Heuts, MW Fraaije, ... Advances in applied microbiology 60, 17, 2006 | 84 | 2006 |
| Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase NGH Leferink, C Han, SV Antonyuk, DJ Heyes, SEJ Rigby, MA Hough, ... Biochemistry 50 (19), 4121-4131, 2011 | 75 | 2011 |
| Structural basis of catalysis in the bacterial monoterpene synthases linalool synthase and 1, 8-cineole synthase V Karuppiah, KE Ranaghan, NGH Leferink, LO Johannissen, ... Acs Catalysis 7 (9), 6268-6282, 2017 | 67 | 2017 |
| Galactonolactone dehydrogenase requires a redox-sensitive thiol for optimal production of vitamin C NGH Leferink, E Van Duijn, A Barendregt, AJR Heck, WJH Van Berkel Plant physiology 150 (2), 596-605, 2009 | 62 | 2009 |
| Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase NGH Leferink, SV Antonyuk, JA Houwman, NS Scrutton, RR Eady, ... Nature Communications 5 (1), 4395, 2014 | 49 | 2014 |
| Laboratory evolution of Pyrococcus furiosus alcohol dehydrogenase to improve the production of (2S,5S)-hexanediol at moderate temperatures R Machielsen, NGH Leferink, A Hendriks, SJJ Brouns, HG Hennemann, ... Extremophiles 12, 587-594, 2008 | 49 | 2008 |
| Exploring novel bacterial terpene synthases GK Reddy, NGH Leferink, M Umemura, ST Ahmed, R Breitling, ... PloS one 15 (4), e0232220, 2020 | 48 | 2020 |
| A ‘Plug and Play’ Platform for the Production of Diverse Monoterpene Hydrocarbon Scaffolds in Escherichia coli. NGH Leferink, AJ Jervis, Z Zebec, HS Toogood, S Hay, E Takano, ... ChemistrySelect 1 (9), 1893-1896, 2016 | 47 | 2016 |
| Gating mechanisms for biological electron transfer: Integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent … NGH Leferink, CR Pudney, S Brenner, DJ Heyes, RR Eady, SS Hasnain, ... FEBS letters 586 (5), 578-584, 2012 | 42 | 2012 |
| Experiment and simulation reveal how mutations in functional plasticity regions guide plant monoterpene synthase product outcome NGH Leferink, KE Ranaghan, V Karuppiah, A Currin, MW Van Der Kamp, ... ACS catalysis 8 (5), 3780-3791, 2018 | 37 | 2018 |
| Energy landscapes and catalysis in nitric-oxide synthase A Sobolewska-Stawiarz, NGH Leferink, K Fisher, DJ Heyes, S Hay, ... Journal of Biological Chemistry 289 (17), 11725-11738, 2014 | 37 | 2014 |
| Chemo-enzymatic routes towards the synthesis of bio-based monomers and polymers ST Ahmed, NGH Leferink, NS Scrutton Molecular catalysis 467, 95-110, 2019 | 35 | 2019 |
| Towards the free energy landscape for catalysis in mammalian nitric oxide synthases NGH Leferink, S Hay, SEJ Rigby, NS Scrutton The FEBS Journal 282 (16), 3016-3029, 2015 | 34 | 2015 |
| Isopentenol Utilization Pathway for the Production of Linalool in Escherichia coli Using an Improved Bacterial Linalool/Nerolidol Synthase CA Ferraz, NGH Leferink, I Kosov, NS Scrutton ChemBioChem 22 (13), 2325-2334, 2021 | 30 | 2021 |
| Communication between L–galactono–1,4–lactone dehydrogenase and cytochrome c M Hervás, Q Bashir, NGH Leferink, P Ferreira, B Moreno‐Beltrán, ... The FEBS journal 280 (8), 1830-1840, 2013 | 30 | 2013 |
Nigel ScruttonProfessor of Enzymology, Manchester Institute of Biotechnology (MIB) and School of Chemistry在 manchester.ac.uk 的电子邮件经过验证
