| Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer J Weisner, I Landel, C Reintjes, N Uhlenbrock, M Trajkovic-Arsic, ... Cancer research 79 (9), 2367-2378, 2019 | 82 | 2019 |
| Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt N Uhlenbrock, S Smith, J Weisner, I Landel, M Lindemann, TA Le, ... Chemical Science 10 (12), 3573-3585, 2019 | 54 | 2019 |
| Covalent‐allosteric inhibitors to achieve Akt isoform‐selectivity L Quambusch, I Landel, L Depta, J Weisner, N Uhlenbrock, MP Müller, ... Angewandte Chemie International Edition 58 (52), 18823-18829, 2019 | 53 | 2019 |
| Spotlight on AKT: current therapeutic challenges I Landel, L Quambusch, L Depta, D Rauh ACS Medicinal Chemistry Letters 11 (3), 225-227, 2020 | 37 | 2020 |
| Cellular model system to dissect the isoform-selectivity of Akt inhibitors L Quambusch, L Depta, I Landel, M Lubeck, T Kirschner, J Nabert, ... Nature Communications 12 (1), 5297, 2021 | 22 | 2021 |
| Covalent lipid pocket ligands targeting p38α MAPK mutants M Bührmann, J Hardick, J Weisner, L Quambusch, D Rauh Angewandte Chemie International Edition 56 (43), 13232-13236, 2017 | 17 | 2017 |
| An unusual intramolecular halogen bond guides conformational selection R Tesch, C Becker, MP Müller, ME Beck, L Quambusch, M Getlik, ... Angewandte Chemie International Edition 57 (31), 9970-9975, 2018 | 13 | 2018 |
| Profiling human hypothalamic neurons reveals a candidate combination drug therapy for weight loss HJC Chen, A Yang, S Mazzaferro, I Mali, O Cahn, K Kentistou, C Rowley, ... bioRxiv, 2023.07. 18.549357, 2023 | 2 | 2023 |
| Covalent allosteric inhibitors of Akt generated using a click fragment approach L van der Westhuizen, J Weisner, A Taher, I Landel, L Quambusch, ... ChemMedChem 17 (10), e202100776, 2022 | 2 | 2022 |
| Front Cover: Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach (ChemMedChem 10/2022) L van der Westhuizen, J Weisner, A Taher, I Landel, L Quambusch, ... ChemMedChem 17 (10), e202200252, 2022 | | 2022 |
| Strukturbasierte Entwicklung und Evaluierung von Sondenmolekülen zur allosterischen Regulation von Isoformen der Proteinkinase Akt L Quambusch | | 2021 |
| Eine ungewöhnliche intramolekulare Halogenbindung führt zu konformationeller Selektion R Tesch, C Becker, MP Müller, ME Beck, L Quambusch, M Getlik, ... Angewandte Chemie 130 (31), 10120-10126, 2018 | | 2018 |
| Kovalente Liganden zur Adressierung einer lipophilen Bindetasche in der MAPK p38α M Bührmann, J Hardick, J Weisner, L Quambusch, D Rauh Angewandte Chemie 129 (43), 13415-13419, 2017 | | 2017 |
Prof. Dr. Daniel RauhChair of Chemical Biology and Medicinal Chemistry, TU Dortmund University, Dortmund, Germany在 tu-dortmund.de 的电子邮件经过验证
