Insights into the pathogenic mechanisms of Chromosome 9 open reading frame 72 (C9orf72) repeat expansions TW Todd, L Petrucelli Journal of neurochemistry 138, 145-162, 2016 | 87 | 2016 |
Aggregation formation in the polyglutamine diseases: protection at a cost? TW Todd, J Lim Molecules and cells 36 (3), 185-194, 2013 | 75 | 2013 |
Chimeric peptide species contribute to divergent dipeptide repeat pathology in c9ALS/FTD and SCA36 ZT McEachin, TF Gendron, N Raj, M García-Murias, A Banerjee, ... Neuron 107 (2), 292-305. e6, 2020 | 62 | 2020 |
Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD Y Wu, W Shao, TW Todd, J Tong, M Yue, S Koga, M Castanedes-Casey, ... Cell Reports 36 (8), 109581, 2021 | 50 | 2021 |
Hexanucleotide repeat expansions in c9FTD/ALS and SCA36 confer selective patterns of neurodegeneration in vivo TW Todd, ZT McEachin, J Chew, AR Burch, K Jansen-West, J Tong, ... Cell reports 31 (5), 107616, 2020 | 44 | 2020 |
Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration W Shao, TW Todd, Y Wu, CY Jones, J Tong, K Jansen-West, ... Science 378 (6615), 94-99, 2022 | 41 | 2022 |
Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1 H Ju, H Kokubu, TW Todd, JJ Kahle, S Kim, R Richman, K Chirala, HT Orr, ... Journal of Neuroscience 33 (22), 9328-9336, 2013 | 34 | 2013 |
Modelling amyotrophic lateral sclerosis in rodents TW Todd, L Petrucelli Nature Reviews Neuroscience 23 (4), 231-251, 2022 | 27 | 2022 |
Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy TW Todd, H Kokubu, HC Miranda, CJ Cortes, AR La Spada, J Lim Elife 4, e08493, 2015 | 17 | 2015 |
TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains V Estades Ayuso, S Pickles, T Todd, M Yue, K Jansen-West, Y Song, ... Molecular neurodegeneration 18 (1), 57, 2023 | 13 | 2023 |
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia JD Marks, VE Ayuso, Y Carlomagno, M Yue, TW Todd, Y Hao, Z Li, ... Science Translational Medicine 16 (730), eadf9735, 2024 | 8 | 2024 |
The endolysosomal pathway and ALS/FTD TW Todd, W Shao, Y Zhang, L Petrucelli Trends in neurosciences 46 (12), 1025-1041, 2023 | 7 | 2023 |
Plasma PolyQ-ATXN3 Levels Associate With Cerebellar Degeneration and Behavioral Abnormalities in a New AAV-Based SCA3 Mouse Model K Jansen-West, TW Todd, LM Daughrity, M Yue, J Tong, Y Carlomagno, ... Frontiers in Cell and Developmental Biology 10, 863089, 2022 | 7 | 2022 |
HDAC6 interacts with poly (GA) and modulates its accumulation in c9FTD/ALS G Del Rosso, Y Carlomagno, TW Todd, CY Jones, M Prudencio, ... Frontiers in Cell and Developmental Biology 9, 809942, 2022 | 7 | 2022 |
Neurodegenerative diseases and RNA-mediated toxicity TW Todd, L Petrucelli The Molecular and Cellular Basis of Neurodegenerative Diseases, 441-475, 2018 | 6 | 2018 |
Amyotrophic lateral sclerosis—insight into susceptibility TW Todd, L Petrucelli Nature Reviews Neurology 18 (4), 189-190, 2022 | 2 | 2022 |
Generation and characterization of monoclonal antibodies against pathologically phosphorylated TDP-43 P Castellanos Otero, TW Todd, W Shao, CJ Jones, K Huang, ... Plos one 19 (4), e0298080, 2024 | 1 | 2024 |
Cryo-EM structures of pathogenic fibrils and their impact on neurodegenerative disease research TW Todd, NN Islam, CN Cook, TR Caulfield, L Petrucelli Neuron, 2024 | | 2024 |
Nemo-like Kinase Modulates the Pathogenesis of the Polyglutamine Disease Spinal and Bulbar Muscular Atrophy TW Todd Yale University, 2015 | | 2015 |