| Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis MB Goldring, M Otero, DA Plumb, C Dragomir, M Favero, K El Hachem, ... European cells & materials 21, 202, 2011 | 559 | 2011 |
| Adjacent segment degeneration after fusion spinal surgery—a systematic review K Hashimoto, T Aizawa, H Kanno, E Itoi International orthopaedics 43, 987-993, 2019 | 191 | 2019 |
| DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes K Hashimoto, ROC Oreffo, MB Gibson, MB Goldring, HI Roach Arthritis & Rheumatism: Official Journal of the American College of …, 2009 | 191 | 2009 |
| Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites K Hashimoto, M Otero, K Imagawa, MC De Andrés, JM Coico, HI Roach, ... Journal of Biological Chemistry 288 (14), 10061-10072, 2013 | 177 | 2013 |
| The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes–implications for osteoarthritis K Imagawa, MC De Andrés, K Hashimoto, D Pitt, E Itoi, MB Goldring, ... Biochemical and biophysical research communications 405 (3), 362-367, 2011 | 143 | 2011 |
| Human chondrocyte cultures as models of cartilage-specific gene regulation M Otero, M Favero, C Dragomir, KE Hachem, K Hashimoto, DA Plumb, ... Human cell culture protocols, 301-336, 2012 | 142* | 2012 |
| Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation KSC Cheung, K Hashimoto, N Yamada, HI Roach Rheumatology international 29, 525-534, 2009 | 138 | 2009 |
| Improved quantification of DNA methylation using methylation-sensitive restriction enzymes and real-time PCR K Hashimoto, S Kokubun, E Itoi, HI Roach Epigenetics 2 (2), 86-91, 2007 | 101 | 2007 |
| Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis A Takahashi, MC De Andrés, K Hashimoto, E Itoi, ROC Oreffo Osteoarthritis and cartilage 23 (11), 1946-1954, 2015 | 100 | 2015 |
| Loss of methylation in CpG sites in the NF‐κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes MC De Andrés, K Imagawa, K Hashimoto, A Gonzalez, HI Roach, ... Arthritis & Rheumatism 65 (3), 732-742, 2013 | 99 | 2013 |
| E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress M Otero, DA Plumb, K Tsuchimochi, CL Dragomir, K Hashimoto, H Peng, ... Journal of Biological Chemistry 287 (5), 3559-3572, 2012 | 85 | 2012 |
| Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation K Imagawa, MC De Andrés, K Hashimoto, E Itoi, M Otero, HI Roach, ... Arthritis & rheumatology 66 (11), 3040-3051, 2014 | 78 | 2014 |
| Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis MC de Andrés, K Imagawa, K Hashimoto, A Gonzalez, MB Goldring, ... Biochemical and biophysical research communications 407 (1), 54-59, 2011 | 76 | 2011 |
| Human chondrocyte cultures as models of cartilage-specific gene regulation M Otero, M Favero, C Dragomir, KE Hachem, K Hashimoto, DA Plumb, ... Human cell culture protocols, 301-336, 2012 | 73 | 2012 |
| DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes A Takahashi, MC de Andrés, K Hashimoto, E Itoi, M Otero, MB Goldring, ... Scientific Reports 7 (1), 7771, 2017 | 60 | 2017 |
| Increasing incidence of degenerative spinal diseases in Japan during 25 years: the registration system of spinal surgery in Tohoku University spine society T Aizawa, S Kokubun, H Ozawa, T Kusakabe, Y Tanaka, T Hoshikawa, ... The Tohoku Journal of Experimental Medicine 238 (2), 153-163, 2016 | 49 | 2016 |
| ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by inhibiting SOX9-CBP/p300-driven histone acetyltransferase activity M Otero, H Peng, KE Hachem, KL Culley, EB Wondimu, J Quinn, ... Connective tissue research 58 (1), 15-26, 2017 | 38 | 2017 |
| Reoperation rates after fenestration for lumbar spinal canal stenosis: a 20-year period survival function method analysis T Aizawa, H Ozawa, T Kusakabe, Y Tanaka, A Sekiguchi, K Hashimoto, ... European Spine Journal 24, 381-387, 2015 | 35 | 2015 |
| Osteosarcoma arising from giant cell tumor of bone ten years after primary surgery: a case report and review of the literature K Hashimoto, M Hatori, M Hosaka, M Watanabe, T Hasegawa, S Kokubun The Tohoku Journal of Experimental Medicine 208 (2), 157-162, 2006 | 32 | 2006 |
| A whole-genome transcriptome analysis of articular chondrocytes in secondary osteoarthritis of the hip T Aki, K Hashimoto, M Ogasawara, E Itoi PloS one 13 (6), e0199734, 2018 | 28 | 2018 |
