| Glyoxal as an alternative fixative to formaldehyde in immunostaining and super‐resolution microscopy KN Richter, NH Revelo, KJ Seitz, MS Helm, D Sarkar, RS Saleeb, E d'Este, ... The EMBO journal 37 (1), 139-159, 2018 | 265 | 2018 |
| Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation DF Lázaro, EF Rodrigues, R Langohr, H Shahpasandzadeh, T Ribeiro, ... PLoS genetics 10 (11), e1004741, 2014 | 242 | 2014 |
| Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons J Pujols, S Peña-Díaz, DF Lázaro, F Peccati, F Pinheiro, D González, ... Proceedings of the National Academy of Sciences 115 (41), 10481-10486, 2018 | 207 | 2018 |
| The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease RM de Oliveira, H Vicente Miranda, L Francelle, R Pinho, ÉM Szegö, ... PLoS biology 15 (3), e2000374, 2017 | 176 | 2017 |
| Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration P Wales, R Pinho, DF Lázaro, TF Outeiro Journal of Parkinson's disease 3 (4), 415-459, 2013 | 116 | 2013 |
| Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells R Perfeito, DF Lázaro, TF Outeiro, AC Rego Molecular and Cellular Neuroscience 62, 51-59, 2014 | 113 | 2014 |
| α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner G Yin, TL Da Fonseca, SE Eisbach, AM Anduaga, C Breda, ML Orcellet, ... Neurobiology of disease 70, 149-161, 2014 | 103 | 2014 |
| Synucleinopathies: Where we are and where we need to go IC Brás, A Dominguez‐Meijide, E Gerhardt, D Koss, DF Lázaro, PI Santos, ... Journal of Neurochemistry 153 (4), 433-454, 2020 | 87 | 2020 |
| Secretion and uptake of α-synuclein via extracellular vesicles in cultured cells G Gustafsson, C Lööv, E Persson, DF Lázaro, S Takeda, J Bergström, ... Cellular and molecular neurobiology 38, 1539-1550, 2018 | 84 | 2018 |
| Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease DF Lázaro, MAS Pavlou, TF Outeiro Experimental neurology 298, 162-171, 2017 | 73 | 2017 |
| Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function I Paiva, G Jain, DF Lázaro, KG Jerčić, T Hentrich, C Kerimoglu, R Pinho, ... Neurobiology of disease 119, 121-135, 2018 | 69 | 2018 |
| C-terminal tyrosine residue modifications modulate the protective phosphorylation of serine 129 of α-synuclein in a yeast model of Parkinson's disease A Kleinknecht, B Popova, DF Lázaro, R Pinho, O Valerius, TF Outeiro, ... PLoS genetics 12 (6), e1006098, 2016 | 64 | 2016 |
| Small molecules detected by second-harmonic generation modulate the conformation of monomeric α-synuclein and reduce its aggregation in cells B Moree, G Yin, DF Lázaro, F Munari, T Strohäker, K Giller, S Becker, ... Journal of Biological Chemistry 290 (46), 27582-27593, 2015 | 52 | 2015 |
| Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo A Dominguez-Meijide, V Parrales, E Vasili, F González-Lizárraga, ... Neurobiology of Disease 151, 105256, 2021 | 50 | 2021 |
| The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation DF Lázaro, MC Dias, A Carija, S Navarro, CS Madaleno, S Tenreiro, ... Acta neuropathologica communications 4, 1-15, 2016 | 50 | 2016 |
| Alpha-synuclein regulates neuronal levels of manganese and calcium T Ducic, E Carboni, B Lai, S Chen, B Michalke, DF Lázaro, TF Outeiro, ... ACS Chemical Neuroscience 6 (10), 1769-1779, 2015 | 43 | 2015 |
| Glycation potentiates neurodegeneration in models of Huntington’s disease H Vicente Miranda, MA Gomes, J Branco-Santos, C Breda, DF Lázaro, ... Scientific Reports 6 (1), 36798, 2016 | 36 | 2016 |
| Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death E Turriani, DF Lázaro, S Ryazanov, A Leonov, A Giese, M Schön, ... Proceedings of the National Academy of Sciences 114 (25), E4971-E4977, 2017 | 32 | 2017 |
| Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity A Carija, F Pinheiro, J Pujols, IC Brás, DF Lázaro, C Santambrogio, ... Redox biology 22, 101135, 2019 | 31 | 2019 |
| X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper (I)/copper (II)-α-Syn interactions and affects protein aggregation in a … DS Cukierman, DF Lázaro, P Sacco, PR Ferreira, R Diniz, CO Fernández, ... Dalton Transactions 49 (45), 16252-16267, 2020 | 24 | 2020 |
