Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A BM Sutter, X Wu, S Laxman, BP Tu Cell 154 (2), 403-415, 2013 | 259 | 2013 |
Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation S Laxman, BM Sutter, X Wu, S Kumar, X Guo, DC Trudgian, H Mirzaei, ... Cell 154 (2), 416-429, 2013 | 247 | 2013 |
Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms S Laxman, A Riechers, M Sadilek, F Schwede, JA Beavo Proceedings of the National Academy of Sciences 103 (50), 19194-19199, 2006 | 109 | 2006 |
The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast C Erkut, VR Gade, S Laxman, TV Kurzchalia Elife 5, e13614, 2016 | 96 | 2016 |
Metabolite regulation of nuclear localization of carbohydrate-response element-binding protein (ChREBP): role of AMP as an allosteric inhibitor S Sato, H Jung, T Nakagawa, R Pawlosky, T Takeshima, WR Lee, ... Journal of Biological Chemistry 291 (20), 10515-10527, 2016 | 82 | 2016 |
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase SC Tso, X Qi, WJ Gui, JL Chuang, LK Morlock, AL Wallace, K Ahmed, ... Proceedings of the National Academy of Sciences 110 (24), 9728-9733, 2013 | 76 | 2013 |
A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis R Gupta, AS Walvekar, S Liang, Z Rashida, P Shah, S Laxman eLife 8, e44795, 2019 | 65 | 2019 |
Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A S Laxman, BM Sutter, BP Tu Autophagy 10 (2), 386-387, 2014 | 62 | 2014 |
Cyclic nucleotide signaling mechanisms in trypanosomes: possible targets for therapeutic agents S Laxman, JA Beavo Molecular interventions 7 (4), 203, 2007 | 61 | 2007 |
Decoding the stem cell quiescence cycle - lessons from yeast for regenerative biology. J Dhawan, S Laxman Journal of Cell Science 128 (24), 4467-74, 2015 | 53 | 2015 |
Npr2 regulates cellular utilization of glutamine for biosynthesis of nitrogen-containing metabolites through TORC1 S Laxman, BM Sutter, L Shi, BP Tu Science signaling 7 (356), ra120, 2014 | 52* | 2014 |
Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature S Kunz, JA Beavo, MA D'angelo, MM Flawia, SH Francis, A Johner, ... Elsevier Science, 2006 | 51 | 2006 |
Regulation of hematopoiesis and methionine homeostasis by mTORC1 inhibitor NPRL2 PA Dutchak, S Laxman, SJ Estill, C Wang, Y Wang, Y Wang, GB Bulut, ... Cell reports 12 (3), 371-379, 2015 | 50 | 2015 |
Metabolic constraints drive self-organization of specialized cell groups S Varahan, A Walvekar, V Sinha, S Krishna, S Laxman eLife 8, e46735, 2019 | 48 | 2019 |
Methionine coordinates a hierarchically organized anabolic program enabling proliferation. A Walvekar, R Srinivasan, R Gupta, S Laxman Molecular Biology of the Cell, 2018 | 45 | 2018 |
A versatile LC-MS/MS approach for comprehensive, quantitative analysis of central metabolic pathways A Walvekar, Z Rashida, H Maddali, S Laxman Wellcome open research 3, 2018 | 42 | 2018 |
Methionine at the heart of anabolism and signaling: perspectives from budding yeast AS Walvekar, S Laxman Frontiers in microbiology 10, 2624, 2019 | 38 | 2019 |
Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain S Laxman, A Rascón, JA Beavo Journal of Biological Chemistry 280 (5), 3771-3779, 2005 | 37 | 2005 |
Anabolic SIRT4 exerts retrograde control over TORC1 signaling by glutamine sparing in the mitochondria E Shaw, M Talwadekar, Z Rashida, N Mohan, A Acharya, S Khatri, ... Molecular and cellular biology, 2020 | 31 | 2020 |
Behavior of a metabolic cycling population at the single cell level as visualized by fluorescent gene expression reporters S Laxman, BM Sutter, BP Tu PloS one 5 (9), e12595, 2010 | 31 | 2010 |