Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing L Rasche, SS Chavan, OW Stephens, PH Patel, R Tytarenko, C Ashby, ... Nature communications 8 (1), 268, 2017 | 362 | 2017 |
Tumour lineage shapes BRCA-mediated phenotypes P Jonsson, C Bandlamudi, ML Cheng, P Srinivasan, SS Chavan, ... Nature 571 (7766), 576-579, 2019 | 360 | 2019 |
First-line pembrolizumab and trastuzumab in HER2-positive oesophageal, gastric, or gastro-oesophageal junction cancer: an open-label, single-arm, phase 2 trial YY Janjigian, SB Maron, WK Chatila, B Millang, SS Chavan, C Alterman, ... The Lancet Oncology 21 (6), 821-831, 2020 | 306 | 2020 |
Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma N Weinhold, C Ashby, L Rasche, SS Chavan, C Stein, OW Stephens, ... Blood, The Journal of the American Society of Hematology 128 (13), 1735-1744, 2016 | 215 | 2016 |
Genomic correlates of disease progression and treatment response in prospectively characterized gliomas P Jonsson, AL Lin, RJ Young, NM DiStefano, DM Hyman, BT Li, ... Clinical Cancer Research 25 (18), 5537-5547, 2019 | 129 | 2019 |
Inhibiting MEK in MAPK pathway-activated myeloma CJ Heuck, Y Jethava, R Khan, F Van Rhee, M Zangari, S Chavan, ... Leukemia 30 (4), 976-980, 2016 | 113 | 2016 |
The spectrum and clinical impact of epigenetic modifier mutations in myeloma C Pawlyn, MF Kaiser, C Heuck, L Melchor, CP Wardell, A Murison, ... Clinical cancer research 22 (23), 5783-5794, 2016 | 105 | 2016 |
Multiomic analysis of lung tumors defines pathways activated in neuroendocrine transformation A Quintanal-Villalonga, H Taniguchi, YA Zhan, MM Hasan, SS Chavan, ... Cancer discovery 11 (12), 3028-3047, 2021 | 86 | 2021 |
An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification OW Stephens, Q Zhang, P Qu, Y Zhou, S Chavan, E Tian, DR Williams, ... Blood, The Journal of the American Society of Hematology 119 (2), 503-512, 2012 | 81 | 2012 |
Genomic landscape of uterine sarcomas defined through prospective clinical sequencing ML Hensley, SS Chavan, DB Solit, R Murali, R Soslow, S Chiang, ... Clinical Cancer Research 26 (14), 3881-3888, 2020 | 78 | 2020 |
Bi-allelic inactivation is more prevalent at relapse in multiple myeloma, identifying RB1 as an independent prognostic marker SS Chavan, J He, R Tytarenko, S Deshpande, P Patel, M Bailey, CK Stein, ... Blood cancer journal 7 (2), e535-e535, 2017 | 73 | 2017 |
The context-specific role of germline pathogenicity in tumorigenesis P Srinivasan, C Bandlamudi, P Jonsson, Y Kemel, SS Chavan, ... Nature genetics 53 (11), 1577-1585, 2021 | 63 | 2021 |
WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC H Taniguchi, R Caeser, SS Chavan, YA Zhan, A Chow, P Manoj, F Uddin, ... Cell reports 39 (7), 2022 | 50 | 2022 |
The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer A Chow, FZ Uddin, M Liu, A Dobrin, BY Nabet, L Mangarin, Y Lavin, ... Immunity 56 (1), 93-106. e6, 2023 | 41 | 2023 |
Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor J Taylor, MTA Donoghue, C Ho, K Petrova-Drus, HA Al-Ahmadie, SA Funt, ... The Journal of clinical investigation 130 (12), 6668-6676, 2020 | 39 | 2020 |
Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation A Quintanal-Villalonga, H Taniguchi, YA Zhan, MM Hasan, SS Chavan, ... Journal of Hematology & Oncology 14, 1-19, 2021 | 35 | 2021 |
Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts R Caeser, JV Egger, S Chavan, ND Socci, CB Jones, FE Kombak, ... Nature Communications 13 (1), 2144, 2022 | 30 | 2022 |
The varied distribution and impact of RAS codon and other key DNA alterations across the translocation cyclin D subgroups in multiple myeloma CK Stein, C Pawlyn, S Chavan, L Rasche, N Weinhold, A Corken, A Buros, ... Oncotarget 8 (17), 27854, 2017 | 30 | 2017 |
Inhibition of XPO1 sensitizes small cell lung cancer to first-and second-line chemotherapy A Quintanal-Villalonga, H Taniguchi, Y Hao, A Chow, YA Zhan, ... Cancer research 82 (3), 472-483, 2022 | 27 | 2022 |
Towards the integration, annotation and association of historical microarray experiments with RNA-seq SS Chavan, MA Bauer, EA Peterson, CJ Heuck, DJ Johann BMC bioinformatics 14, 1-11, 2013 | 27 | 2013 |