Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORγ L Jin, D Martynowski, S Zheng, T Wada, W Xie, Y Li Molecular endocrinology 24 (5), 923-929, 2010 | 247 | 2010 |
Vertical sleeve gastrectomy activates GPBAR‐1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice L Ding, KM Sousa, L Jin, B Dong, BW Kim, R Ramirez, Z Xiao, Y Gu, ... Hepatology 64 (3), 760-773, 2016 | 177 | 2016 |
The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism L Jin, X Feng, H Rong, Z Pan, Y Inaba, L Qiu, W Zheng, S Lin, R Wang, ... Nature communications 4 (1), 1937, 2013 | 154 | 2013 |
Structural and functional insights into nuclear receptor signaling L Jin, Y Li Advanced drug delivery reviews 62 (13), 1218-1226, 2010 | 120 | 2010 |
Detection of point mutations of the Axin1 gene in colorectal cancers LH Jin, QJ Shao, W Luo, ZY Ye, Q Li, SC Lin International journal of cancer 107 (5), 696-699, 2003 | 108 | 2003 |
Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation W Luo, WW Ng, LH Jin, Z Ye, J Han, SC Lin Journal of Biological Chemistry 278 (39), 37451-37458, 2003 | 92 | 2003 |
Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions W Luo, H Zou, L Jin, S Lin, Q Li, Z Ye, H Rui, SC Lin Journal of Biological Chemistry 280 (6), 5054-5060, 2005 | 73 | 2005 |
Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency W Zheng, L Qiu, R Wang, X Feng, Y Han, Y Zhu, D Chen, Y Liu, L Jin, Y Li Scientific reports 5 (1), 12222, 2015 | 62 | 2015 |
Novel gelatin–siloxane nanoparticles decorated by Tat peptide as vectors for gene therapy Z Wang, Y Zhao, L Ren, L Jin, L Sun, P Yin, Y Zhang, QQ Zhang Nanotechnology 19 (44), 445103, 2008 | 54 | 2008 |
Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease L Jin, R Wang, Y Zhu, W Zheng, Y Han, F Guo, FB Ye, Y Li Scientific reports 5 (1), 17288, 2015 | 46 | 2015 |
Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis E Zhang, L Jin, Y Wang, J Tu, R Zheng, L Ding, Z Fang, M Fan, ... Nature Communications 13 (1), 1135, 2022 | 40 | 2022 |
Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice L Ding, E Zhang, Q Yang, L Jin, KM Sousa, B Dong, Y Wang, J Tu, X Ma, ... Proceedings of the National Academy of Sciences 118 (6), e2019388118, 2021 | 34 | 2021 |
Structural basis for iloprost as a dual peroxisome proliferator-activated receptor α/δ agonist L Jin, S Lin, H Rong, S Zheng, S Jin, R Wang, Y Li Journal of Biological Chemistry 286 (36), 31473-31479, 2011 | 34 | 2011 |
Identification of an oleanane-type triterpene hedragonic acid as a novel farnesoid X receptor ligand with liver protective effects and anti-inflammatory activity Y Lu, W Zheng, S Lin, F Guo, Y Zhu, Y Wei, X Liu, S Jin, L Jin, Y Li Molecular pharmacology 93 (2), 63-72, 2018 | 33 | 2018 |
Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose … W Zheng, X Feng, L Qiu, Z Pan, R Wang, S Lin, D Hou, L Jin, Y Li Diabetologia 56, 401-411, 2013 | 32 | 2013 |
CAMK2γ in intestinal epithelial cells modulates colitis-associated colorectal carcinogenesis via enhancing STAT3 activation X Ma, Z Meng, L Jin, Z Xiao, X Wang, WM Tsark, L Ding, Y Gu, J Zhang, ... Oncogene 36 (28), 4060-4071, 2017 | 28 | 2017 |
Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells S Wang, Z Wang, S Lin, W Zheng, R Wang, S Jin, J Chen, L Jin, Y Li Biochemical Journal 446 (1), 79-87, 2012 | 24 | 2012 |
Bile acid–mediated activation of brown fat protects from alcohol-induced steatosis and liver injury in mice M Fan, Y Wang, L Jin, Z Fang, J Peng, J Tu, Y Liu, E Zhang, S Xu, X Liu, ... Cellular and Molecular Gastroenterology and Hepatology 13 (3), 809-826, 2022 | 23 | 2022 |
Bile acids, gut microbiota and metabolic surgery J Tu, Y Wang, L Jin, W Huang Frontiers in Endocrinology 13, 929530, 2022 | 21 | 2022 |
Identification of an allosteric hotspot for additive activation of PPARγ in antidiabetic effects L Feng, S Lu, Z Zheng, Y Chen, Y Zhao, K Song, H Xue, L Jin, Y Li, ... Science Bulletin 66 (15), 1559-1570, 2021 | 21 | 2021 |