| The role of kinetic context in apparent biased agonism at GPCRs C Klein Herenbrink, DA Sykes, P Donthamsetti, M Canals, T Coudrat, ... Nature communications 7 (1), 10842, 2016 | 335 | 2016 |
| GPCR crystal structures: medicinal chemistry in the pocket J Shonberg, RC Kling, P Gmeiner, S Löber Bioorganic & medicinal chemistry 23 (14), 3880-3906, 2015 | 138 | 2015 |
| A new mechanism of allostery in a G protein–coupled receptor dimer JR Lane, P Donthamsetti, J Shonberg, CJ Draper-Joyce, S Dentry, ... Nature chemical biology 10 (9), 745-752, 2014 | 125 | 2014 |
| Biased agonism at G protein‐coupled receptors: the promise and the challenges—a medicinal chemistry perspective J Shonberg, L Lopez, PJ Scammells, A Christopoulos, B Capuano, ... Medicinal research reviews 34 (6), 1286-1330, 2014 | 122 | 2014 |
| Design strategies for bivalent ligands targeting GPCRs J Shonberg, PJ Scammells, B Capuano ChemMedChem 6 (6), 963-974, 2011 | 118 | 2011 |
| A structure–activity analysis of biased agonism at the dopamine D2 receptor J Shonberg, CK Herenbrink, L Lopez, A Christopoulos, PJ Scammells, ... Journal of medicinal chemistry 56 (22), 9199-9221, 2013 | 105 | 2013 |
| Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand SN Mistry, J Shonberg, CJ Draper-Joyce, C Klein Herenbrink, M Michino, ... Journal of medicinal chemistry 58 (17), 6819-6843, 2015 | 55 | 2015 |
| Structure–Activity Study of N-((trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a Bitopic Ligand That Acts as a … J Shonberg, C Draper-Joyce, SN Mistry, A Christopoulos, PJ Scammells, ... Journal of Medicinal Chemistry 58 (13), 5287-5307, 2015 | 45 | 2015 |
| 8‐Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase ML Dennis, MD Lee, JR Harjani, M Ahmed, AJ DeBono, NP Pitcher, ... Chemistry–A European Journal 24 (8), 1922-1930, 2018 | 42 | 2018 |
| Hydroxy-Substituted Heteroarylpiperazines: Novel Scaffolds for β-Arrestin-Biased D2R Agonists B Männel, D Dengler, J Shonberg, H Hübner, D Möller, P Gmeiner Journal of medicinal chemistry 60 (11), 4693-4713, 2017 | 39 | 2017 |
| The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor CJ Draper-Joyce, M Michino, RK Verma, CK Herenbrink, J Shonberg, ... Biochemical pharmacology 148, 315-328, 2018 | 28 | 2018 |
| Novel adenosine A2A receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A2A receptor antagonists for extending into … M Jörg, J Shonberg, FS Mak, ND Miller, E Yuriev, PJ Scammells, ... Bioorganic & medicinal chemistry letters 23 (11), 3427-3433, 2013 | 28 | 2013 |
| Molecular determinants of the intrinsic efficacy of the antipsychotic aripiprazole C Klein Herenbrink, R Verma, HD Lim, A Kopinathan, A Keen, J Shonberg, ... ACS chemical biology 14 (8), 1780-1792, 2019 | 24 | 2019 |
| Novel adenosine A2A receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A2A receptor antagonists for extending into … MT Jorg, J Shonberg, FS Mak, ND Miller, E Yuriev, PJ Scammells, ... Bioorganic and Medicinal Chemistry Letters 23 (11), 3427-3433, 2013 | 20 | 2013 |
| The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions CJ Draper-Joyce, RK Verma, M Michino, J Shonberg, A Kopinathan, ... Scientific Reports 8 (1), 1208, 2018 | 16 | 2018 |
| Synthesis, functional and binding profile of (R)-apomorphine based homobivalent ligands targeting the dopamine D 2 receptor J Shonberg, JR Lane, PJ Scammells, B Capuano MedChemComm 4 (9), 1290-1296, 2013 | 10 | 2013 |
| Constrained catecholamines gain β2AR selectivity through allosteric effects on pocket dynamics X Xu, J Shonberg, J Kaindl, MJ Clark, A Stößel, L Maul, D Mayer, ... Nature communications 14 (1), 2138, 2023 | 9 | 2023 |
| Beta-2 selective adrenergic receptor agonists R Sunahara, H Huebner, J Shonberg, A STÖßEL, M Stanek, D Möller, ... US Patent 11,590,089, 2023 | 2 | 2023 |
| Author Correction: Constrained catecholamines gain β2AR selectivity through allosteric effects on pocket dynamics X Xu, J Shonberg, J Kaindl, MJ Clark, A Stößel, L Maul, D Mayer, ... nature communications 14, 2023 | | 2023 |
| 27th Annual GP2A Medicinal Chemistry Conference SN Mistry, P Marchand, B Kellam Pharmaceuticals 12 (4), 179, 2019 | | 2019 |
