Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, ... Science 370 (6521), eabe9403, 2020 | 489 | 2020 |
Structure of the human P2Y12 receptor in complex with an antithrombotic drug K Zhang, J Zhang, ZG Gao, D Zhang, L Zhu, GW Han, SM Moss, ... Nature 509 (7498), 115-118, 2014 | 403 | 2014 |
Two disparate ligand-binding sites in the human P2Y1 receptor D Zhang, ZG Gao, K Zhang, E Kiselev, S Crane, J Wang, S Paoletta, C Yi, ... Nature 520 (7547), 317-321, 2015 | 329 | 2015 |
Agonist-bound structure of the human P2Y12 receptor J Zhang, K Zhang, ZG Gao, S Paoletta, D Zhang, GW Han, T Li, L Ma, ... Nature 509 (7498), 119-122, 2014 | 324 | 2014 |
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, ... Science 370 (6523), 1473-1479, 2020 | 307 | 2020 |
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking M Schuller, GJ Correy, S Gahbauer, D Fearon, T Wu, RE Díaz, ID Young, ... Science advances 7 (16), eabf8711, 2021 | 85 | 2021 |
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2 CJ Bracken, SA Lim, P Solomon, NJ Rettko, DP Nguyen, BS Zha, ... Nature Chemical Biology, 1-9, 2020 | 71 | 2020 |
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality K Zhang, D Julius, Y Cheng Cell 184 (20), 5138-5150. e12, 2021 | 67 | 2021 |
An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, ... BioRxiv, 2020 | 57 | 2020 |
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. M Gupta, CM Azumaya, M Moritz, S Pourmal, A Diallo, GE Merz, G Jang, ... Research square, 2021 | 53 | 2021 |
Fusion protein strategies for cryo-EM study of G protein-coupled receptors K Zhang, H Wu, N Hoppe, A Manglik, Y Cheng Nature communications 13 (1), 4366, 2022 | 12 | 2022 |
Autoantibody mimicry of hormone action at the thyrotropin receptor B Faust, CB Billesbølle, CM Suomivuori, I Singh, K Zhang, N Hoppe, ... Nature 609 (7928), 846-853, 2022 | 10 | 2022 |
Consortium QSB, Walter P, Manglik A M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, ... Science 370 (6523), 1473, 2020 | 8 | 2020 |
Autoantibody and hormone activation of the thyrotropin G protein-coupled receptor B Faust, I Singh, K Zhang, N Hoppe, AFM Pinto, Y Muftuoglu, ... bioRxiv, 2022.01. 06.475289, 2022 | 3 | 2022 |
Targeting phosphotyrosine in native proteins with conditional, bispecific antibody traps XX Zhou, CJ Bracken, K Zhang, J Zhou, Y Mou, L Wang, Y Cheng, ... Journal of the American Chemical Society 142 (41), 17703-17713, 2020 | 3 | 2020 |
A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM K Zhang, D Julius, Y Cheng STAR protocols 3 (4), 101732, 2022 | | 2022 |
Fusion protein strategies for cryo-EM study of G protein-coupled receptors K Zhang, H Wu, N Hoppe, A Manglik, Y Cheng Nature Communications, 2022 | | 2022 |
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.(preprint) M Gupta, CM Azumaya, M Moritz, S Pourmal, A Diallo, GE Merz, GM Jang, ... | | 2021 |
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes (preprint) K Verba, M Gupta, C Azumaya, M Moritz, S Pourmal, A Diallo, G Merz, ... | | 2021 |
An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike into an inactive conformation (preprint) M Schoof, B Faust, RA Saunders, S Sangwan, VV Rezelj, N Hoppe, ... | | 2020 |