CAVER 3.0: a tool for the analysis of transport pathways in dynamic protein structures E Chovancova, A Pavelka, P Benes, O Strnad, J Brezovsky, B Kozlikova, ... Public Library of Science 8 (10), e1002708, 2012 | 1036 | 2012 |
PredictSNP: robust and accurate consensus classifier for prediction of disease-related mutations J Bendl, J Stourac, O Salanda, A Pavelka, ED Wieben, J Zendulka, ... PLoS computational biology 10 (1), e1003440, 2014 | 651 | 2014 |
CAVER: a new tool to explore routes from protein clefts, pockets and cavities M Petřek, M Otyepka, P Banáš, P Košinová, J Koča, J Damborský BMC bioinformatics 7, 1-9, 2006 | 624 | 2006 |
Strategies for stabilization of enzymes in organic solvents V Stepankova, S Bidmanova, T Koudelakova, Z Prokop, R Chaloupkova, ... Acs Catalysis 3 (12), 2823-2836, 2013 | 548 | 2013 |
Redesigning dehalogenase access tunnels as a strategy for degrading an anthropogenic substrate M Pavlova, M Klvana, Z Prokop, R Chaloupkova, P Banas, M Otyepka, ... Nature chemical biology 5 (10), 727-733, 2009 | 307 | 2009 |
Bioremediation 3.0: engineering pollutant-removing bacteria in the times of systemic biology P Dvořák, PI Nikel, J Damborský, V de Lorenzo Biotechnology advances 35 (7), 845-866, 2017 | 264 | 2017 |
Gates of enzymes A Gora, J Brezovsky, J Damborsky Chemical reviews 113 (8), 5871-5923, 2013 | 234 | 2013 |
CAVER Analyst 2.0: analysis and visualization of channels and tunnels in protein structures and molecular dynamics trajectories A Jurcik, D Bednar, J Byska, SM Marques, K Furmanova, L Daniel, ... Bioinformatics 34 (20), 3586-3588, 2018 | 232 | 2018 |
Computational tools for designing and engineering enzymes J Damborsky, J Brezovsky Current opinion in chemical biology 19, 8-16, 2014 | 229 | 2014 |
Machine learning in enzyme engineering S Mazurenko, Z Prokop, J Damborsky ACS Catalysis 10 (2), 1210-1223, 2019 | 225 | 2019 |
HotSpot Wizard: a web server for identification of hot spots in protein engineering A Pavelka, E Chovancova, J Damborsky Nucleic acids research 37 (suppl_2), W376-W383, 2009 | 219 | 2009 |
Crystal Structure of the Haloalkane Dehalogenase from Sphingomonas paucimobilis UT26, J Marek, J Vévodová, IK Smatanová, Y Nagata, LA Svensson, J Newman, ... Biochemistry 39 (46), 14082-14086, 2000 | 201 | 2000 |
Exacerbation of substrate toxicity by IPTG in Escherichia coli BL21 (DE3) carrying a synthetic metabolic pathway P Dvorak, L Chrast, PI Nikel, R Fedr, K Soucek, M Sedlackova, ... Microbial cell factories 14 (1), 1-15, 2015 | 196 | 2015 |
Modification of activity and specificity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26 by engineering of its entrance tunnel R Chaloupková, J Sýkorová, Z Prokop, A Jesenská, M Monincová, ... Journal of Biological Chemistry 278 (52), 52622-52628, 2003 | 190 | 2003 |
Purification and characterization of a haloalkane dehalogenase of a new substrate class from a gamma-hexachlorocyclohexane-degrading bacterium, Sphingomonas paucimobilis UT26 Y Nagata, K Miyauchi, J Damborsky, K Manova, A Ansorgova, M Takagi Applied and Environmental Microbiology 63 (9), 3707-3710, 1997 | 188 | 1997 |
Biodegradation of 1, 2, 3-trichloropropane through directed evolution and heterologous expression of a haloalkane dehalogenase gene T Bosma, J Damborský, G Stucki, DB Janssen Applied and environmental microbiology 68 (7), 3582-3587, 2002 | 183 | 2002 |
Haloalkane dehalogenases: biotechnological applications T Koudelakova, S Bidmanova, P Dvorak, A Pavelka, R Chaloupkova, ... Biotechnology journal 8 (1), 32-45, 2013 | 167 | 2013 |
HotSpot Wizard 3.0: web server for automated design of mutations and smart libraries based on sequence input information L Sumbalova, J Stourac, T Martinek, D Bednar, J Damborsky Nucleic acids research 46 (W1), W356-W362, 2018 | 166 | 2018 |
PredictSNP2: a unified platform for accurately evaluating SNP effects by exploiting the different characteristics of variants in distinct genomic regions J Bendl, M Musil, J Štourač, J Zendulka, J Damborský, J Brezovský PLoS computational biology 12 (5), e1004962, 2016 | 160 | 2016 |
CAVER Analyst 1.0: graphic tool for interactive visualization and analysis of tunnels and channels in protein structures B Kozlikova, E Sebestova, V Sustr, J Brezovsky, O Strnad, L Daniel, ... Bioinformatics 30 (18), 2684-2685, 2014 | 156 | 2014 |