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Amy Medlock
Amy Medlock
Associate Professor, University of Georgia
在 uga.edu 的电子邮件经过验证 - 首页
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引用次数
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The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron–sulfur cluster biogenesis
C Pondarré, BB Antiochos, DR Campagna, SL Clarke, EL Greer, KM Deck, ...
Human molecular genetics 15 (6), 953-964, 2006
2502006
Ferrochelatase at the millennium: structures, mechanisms and [2Fe-2S] clusters
HA Dailey*, TA Dailey, CK Wu**, AE Medlock, JP Rose, KF Wang
Cellular and Molecular Life Sciences CMLS 57, 1909-1926, 2000
2042000
A novel role for progesterone receptor membrane component 1 (PGRMC1): a partner and regulator of ferrochelatase
RB Piel III, MT Shiferaw, AA Vashisht, JR Marcero, JL Praissman, ...
Biochemistry 55 (37), 5204-5217, 2016
1162016
Identification of the mitochondrial heme metabolism complex
AE Medlock, MT Shiferaw, JR Marcero, AA Vashisht, JA Wohlschlegel, ...
PloS one 10 (8), e0135896, 2015
1142015
Substrate interactions with human ferrochelatase
A Medlock, L Swartz, TA Dailey, HA Dailey, WN Lanzilotta
Proceedings of the National Academy of Sciences 104 (6), 1789-1793, 2007
1052007
From synthesis to utilization: The ins and outs of mitochondrial heme
SA Swenson, CM Moore, JR Marcero, AE Medlock, AR Reddi, ...
Cells 9 (3), 579, 2020
1042020
Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts
DI Shah, N Takahashi-Makise, JD Cooney, L Li, IJ Schultz, EL Pierce, ...
Nature 491 (7425), 608-612, 2012
1002012
Human coproporphyrinogen oxidase is not a metalloprotein
AE Medlock, HA Dailey
Journal of Biological Chemistry 271 (51), 32507-32510, 1996
851996
Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis
JS Burch, JR Marcero, JA Maschek, JE Cox, LK Jackson, AE Medlock, ...
Blood, The Journal of the American Society of Hematology 132 (10), 987-998, 2018
742018
A π-helix switch selective for porphyrin deprotonation and product release in human ferrochelatase
AE Medlock, TA Dailey, TA Ross, HA Dailey, WN Lanzilotta
Journal of molecular biology 373 (4), 1006-1016, 2007
712007
Product release rather than chelation determines metal specificity for ferrochelatase
AE Medlock, M Carter, TA Dailey, HA Dailey, WN Lanzilotta
Journal of molecular biology 393 (2), 308-319, 2009
652009
Thoughts on interactions between PGRMC1 and diverse attested and potential hydrophobic ligands
MA Cahill, AE Medlock
The Journal of steroid biochemistry and molecular biology 171, 11-33, 2017
562017
The mitochondrial heme metabolon: Insights into the complex (ity) of heme synthesis and distribution
RB Piel III, HA Dailey Jr, AE Medlock
Molecular genetics and metabolism 128 (3), 198-203, 2019
532019
Resonance Raman spectra of ferrochelatase reveal porphyrin distortion upon metal binding
ME Blackwood, TS Rush, A Medlock, HA Dailey, TG Spiro
Journal of the American Chemical Society 119 (50), 12170-12174, 1997
511997
Examination of the activity of carboxyl-terminal chimeric constructs of human and yeast ferrochelatases
AE Medlock, HA Dailey
Biochemistry 39 (25), 7461-7467, 2000
422000
Mitochondrial–nuclear heme trafficking in budding yeast is regulated by GTPases that control mitochondrial dynamics and ER contact sites
O Martinez-Guzman, MM Willoughby, A Saini, JV Dietz, I Bohovych, ...
Journal of cell science 133 (10), jcs237917, 2020
402020
Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis
HA Dailey, CK Wu, P Horanyi, AE Medlock, W Najahi-Missaoui, ...
Biochemistry 46 (27), 7973-7979, 2007
352007
Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase
JV Dietz, MM Willoughby, RB Piel III, TA Ross, I Bohovych, HG Addis, ...
Redox biology 46, 102125, 2021
222021
A mouse model for South African (R59W) variegate porphyria: construction and initial characterization.
AE Medlock, PN Meissner, BP Davidson, AV Corrigall, HA Dailey
Cellular and molecular biology (Noisy-le-Grand, France) 48 (1), 71-78, 2002
212002
A primer on heme biosynthesis
HA Dailey, AE Medlock
Biological Chemistry 403 (11-12), 985-1003, 2022
192022
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