| The Orai1 Store-Operated Calcium Channel Functions as a Hexamer*♦ X Cai, Y Zhou, RM Nwokonko, NA Loktionova, X Wang, P Xin, M Trebak, ... Journal of Biological Chemistry 291 (50), 25764-25775, 2016 | 129 | 2016 |
| The STIM1-binding site nexus remotely controls Orai1 channel gating Y Zhou, X Cai, NA Loktionova, X Wang, RM Nwokonko, X Wang, Y Wang, ... Nature communications 7 (1), 13725, 2016 | 103 | 2016 |
| G-protein activation by a metabotropic glutamate receptor AB Seven, X Barros-Álvarez, M de Lapeyrière, MM Papasergi-Scott, ... Nature 595 (7867), 450-454, 2021 | 88 | 2021 |
| The STIM-Orai coupling interface and gating of the Orai1 channel Y Zhou, X Cai, RM Nwokonko, NA Loktionova, Y Wang, DL Gill Cell calcium 63, 8-13, 2017 | 88 | 2017 |
| STIM1 dimers undergo unimolecular coupling to activate Orai1 channels Y Zhou, X Wang, X Wang, NA Loktionova, X Cai, RM Nwokonko, E Vrana, ... Nature communications 6 (1), 8395, 2015 | 87 | 2015 |
| A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction X Zhang, T Pathak, R Yoast, S Emrich, P Xin, RM Nwokonko, M Johnson, ... Nature communications 10 (1), 1971, 2019 | 85 | 2019 |
| Cross-linking of Orai1 channels by STIM proteins Y Zhou, RM Nwokonko, X Cai, NA Loktionova, R Abdulqadir, P Xin, ... Proceedings of the National Academy of Sciences 115 (15), E3398-E3407, 2018 | 82 | 2018 |
| The tethered peptide activation mechanism of adhesion GPCRs X Barros-Álvarez, RM Nwokonko, A Vizurraga, D Matzov, F He, ... Nature 604 (7907), 757-762, 2022 | 80 | 2022 |
| Calcium store refilling and STIM activation in STIM-and Orai-deficient cell lines S Zheng, L Zhou, G Ma, T Zhang, J Liu, J Li, NT Nguyen, X Zhang, W Li, ... Pflügers Archiv-European Journal of Physiology 470, 1555-1567, 2018 | 51 | 2018 |
| L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins MT Johnson, A Gudlur, X Zhang, P Xin, SM Emrich, RE Yoast, R Courjaret, ... Proceedings of the National Academy of Sciences 117 (29), 17369-17380, 2020 | 44 | 2020 |
| Identification of molecular determinants that govern distinct STIM2 activation dynamics S Zheng, G Ma, L He, T Zhang, J Li, X Yuan, NT Nguyen, Y Huang, ... PLoS biology 16 (11), e2006898, 2018 | 41 | 2018 |
| The oxytocin signaling complex reveals a molecular switch for cation dependence JG Meyerowitz, MJ Robertson, X Barros-Álvarez, O Panova, ... Nature Structural & Molecular Biology 29 (3), 274-281, 2022 | 38 | 2022 |
| The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry RM Nwokonko, X Cai, NA Loktionova, Y Wang, Y Zhou, DL Gill Store-Operated Ca²⁺ Entry (SOCE) Pathways: Emerging Signaling Concepts in …, 2017 | 38 | 2017 |
| Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity SM Emrich, RE Yoast, P Xin, X Zhang, T Pathak, R Nwokonko, ... Journal of Biological Chemistry 294 (16), 6318-6332, 2019 | 36 | 2019 |
| The remote allosteric control of Orai channel gating Y Zhou, RM Nwokonko, JH Baraniak Jr, M Trebak, KPK Lee, DL Gill PLoS biology 17 (8), e3000413, 2019 | 32 | 2019 |
| Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor X Cai, RM Nwokonko, NA Loktionova, R Abdulqadir, JH Baraniak, ... Journal of Biological Chemistry 293 (33), 12962-12974, 2018 | 30 | 2018 |
| Orai channel C-terminal peptides are key modulators of STIM-Orai coupling and calcium signal generation JH Baraniak, Y Zhou, RM Nwokonko, MR Jennette, SA Kazzaz, ... Cell reports 35 (13), 2021 | 18 | 2021 |
| The intricate coupling between STIM proteins and Orai channels JH Baraniak Jr, Y Zhou, RM Nwokonko, DL Gill Current opinion in physiology 17, 106-114, 2020 | 14 | 2020 |
| An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1 Y Zhou, MR Jennette, G Ma, SA Kazzaz, JH Baraniak, RM Nwokonko, ... Nature communications 14 (1), 6921, 2023 | 6 | 2023 |
| STIM1 is a precise thermo-sensor in skin RM Nwokonko, Y Zhou, DL Gill Cell Research 29 (4), 259-260, 2019 | 6 | 2019 |
