Insulin demand regulates β cell number via the unfolded protein response RB Sharma, AC O’Donnell, RE Stamateris, B Ha, KM McCloskey, ... The Journal of clinical investigation 125 (10), 3831-3846, 2015 | 218 | 2015 |
Spondylarthritis in HLA–B27/human β2‐microglobulin–transgenic rats is not prevented by lack of CD8 JD Taurog, ML Dorris, N Satumtira, TM Tran, R Sharma, R Dressel, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2009 | 198 | 2009 |
Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well? RB Sharma, LC Alonso Current diabetes reports 14, 1-9, 2014 | 160 | 2014 |
Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression RE Stamateris, RB Sharma, DA Hollern, LC Alonso American Journal of Physiology-Endocrinology and Metabolism 305 (1), E149-E159, 2013 | 146 | 2013 |
In vivo selection yields AAV-B1 capsid for central nervous system and muscle gene therapy SR Choudhury, Z Fitzpatrick, AF Harris, SA Maitland, JS Ferreira, Y Zhang, ... Molecular Therapy 24 (7), 1247-1257, 2016 | 135 | 2016 |
Glucose induces mouse β-cell proliferation via IRS2, MTOR, and cyclin D2 but not the insulin receptor RE Stamateris, RB Sharma, Y Kong, P Ebrahimpour, D Panday, ... Diabetes 65 (4), 981-995, 2016 | 104 | 2016 |
Islet biology, the CDKN2A/B locus and type 2 diabetes risk Y Kong, RB Sharma, BU Nwosu, LC Alonso Diabetologia 59 (8), 1579-1593, 2016 | 98 | 2016 |
ADAR1 is essential for intestinal homeostasis and stem cell maintenance W Qiu, X Wang, M Buchanan, K He, R Sharma, L Zhang, Q Wang, J Yu Cell death & disease 4 (4), e599-e599, 2013 | 71 | 2013 |
CDKN2A/B T2D genome-wide association study risk SNPs impact locus gene expression and proliferation in human islets Y Kong, RB Sharma, S Ly, RE Stamateris, WM Jesdale, LC Alonso Diabetes 67 (5), 872-884, 2018 | 56 | 2018 |
Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells RB Sharma, C Darko, LC Alonso Journal of Biological Chemistry 295 (41), 14164-14177, 2020 | 45 | 2020 |
Living dangerously: protective and harmful ER stress responses in pancreatic β-cells RB Sharma, HV Landa-Galván, LC Alonso Diabetes 70 (11), 2431-2443, 2021 | 40 | 2021 |
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance S Skovsø, E Panzhinskiy, J Kolic, HH Cen, DA Dionne, XQ Dai, ... Nature communications 13 (1), 735, 2022 | 33 | 2022 |
In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR J Charbord, L Ren, RB Sharma, A Johansson, R Ågren, L Chu, D Tworus, ... Nature metabolism 3 (5), 682-700, 2021 | 29 | 2021 |
Atf6α impacts cell number by influencing survival, death and proliferation RB Sharma, JT Snyder, LC Alonso Molecular Metabolism 27, S69-S80, 2019 | 28 | 2019 |
ADAR1 ablation decreases bone mass by impairing osteoblast function in mice S Yu, R Sharma, D Nie, H Jiao, HJ Im, Y Lai, Z Zhao, K Zhu, J Fan, ... Gene 513 (1), 101-110, 2013 | 28 | 2013 |
Ergocalciferol in new-onset type 1 diabetes: a randomized controlled trial BU Nwosu, S Parajuli, G Jasmin, J Fleshman, RB Sharma, LC Alonso, ... Journal of the Endocrine Society 6 (1), bvab179, 2022 | 22 | 2022 |
An essential role of RNA editing enzyme ADAR1 in mouse skin R Sharma, Y Wang, P Zhou, RA Steinman, Q Wang Journal of dermatological science 64 (1), 70-72, 2011 | 20 | 2011 |
Method and system for tracking and managing network flows S Venkatesan, M Bakshi, R Sharma US Patent 9,608,938, 2017 | 19 | 2017 |
DNA Damage Does Not Cause BrdU Labeling of Mouse or Human β-Cells RB Sharma, C Darko, X Zheng, B Gablaski, LC Alonso Diabetes 68 (5), 975-987, 2019 | 17 | 2019 |
Protein kinase mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) promotes obesity-induced hyperinsulinemia RJR Flach, LV Danai, MT DiStefano, M Kelly, LG Menendez, A Jurczyk, ... Journal of Biological Chemistry 291 (31), 16221-16230, 2016 | 17 | 2016 |