| Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 13331* | 2021 |
| Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide … HT Kim, KP Kim, F Lledias, AF Kisselev, KM Scaglione, D Skowyra, ... Journal of biological chemistry 282 (24), 17375-17386, 2007 | 617 | 2007 |
| CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome PK Todd, SY Oh, A Krans, F He, C Sellier, M Frazer, AJ Renoux, K Chen, ... Neuron 78 (3), 440-455, 2013 | 509 | 2013 |
| The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains BJ Winborn, SM Travis, SV Todi, KM Scaglione, P Xu, AJ Williams, ... Journal of Biological Chemistry 283 (39), 26436-26443, 2008 | 321 | 2008 |
| Accelerated neurodegeneration through chaperone-mediated oligomerization of tau LJ Blair, BA Nordhues, SE Hill, KM Scaglione, JC O’Leary, SN Fontaine, ... The Journal of clinical investigation 123 (10), 4158-4169, 2013 | 314 | 2013 |
| Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin‐3 SV Todi, BJ Winborn, KM Scaglione, JR Blount, SM Travis, HL Paulson The EMBO journal 28 (4), 372-382, 2009 | 220 | 2009 |
| Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP KM Scaglione, E Zavodszky, SV Todi, S Patury, P Xu, ... Molecular cell 43 (4), 599-612, 2011 | 192 | 2011 |
| Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117 SV Todi, KM Scaglione, JR Blount, V Basrur, KP Conlon, A Pastore, ... Journal of Biological Chemistry 285 (50), 39303-39313, 2010 | 114 | 2010 |
| The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates KM Scaglione, V Basrur, NS Ashraf, JR Konen, KSJ Elenitoba-Johnson, ... Journal of Biological Chemistry 288 (26), 18784-18788, 2013 | 109 | 2013 |
| Release of ubiquitin-charged Cdc34-S∼ Ub from the RING domain is essential for ubiquitination of the SCFCdc4-bound substrate Sic1 AE Deffenbaugh, KM Scaglione, L Zhang, JM Moore, T Buranda, LA Sklar, ... Cell 114 (5), 611-622, 2003 | 104 | 2003 |
| A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins H Zhang, J Amick, R Chakravarti, S Santarriaga, S Schlanger, C McGlone, ... Structure 23 (3), 472-482, 2015 | 103 | 2015 |
| Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation AD Thompson, KM Scaglione, J Prensner, AT Gillies, A Chinnaiyan, ... ACS chemical biology 7 (10), 1677-1686, 2012 | 82 | 2012 |
| Intrinsic disorder drives N-terminal ubiquitination by Ube2w V Vittal, L Shi, DM Wenzel, KM Scaglione, ED Duncan, V Basrur, ... Nature chemical biology 11 (1), 83-89, 2015 | 80 | 2015 |
| Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23 JR Blount, WL Tsou, G Ristic, AA Burr, M Ouyang, H Galante, ... Nature communications 5 (1), 4638, 2014 | 71 | 2014 |
| The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex MC Smith, KM Scaglione, VA Assimon, S Patury, AD Thompson, ... Biochemistry 52 (32), 5354-5364, 2013 | 67 | 2013 |
| Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo WL Tsou, AA Burr, M Ouyang, JR Blount, KM Scaglione, SV Todi Journal of Biological Chemistry 288 (48), 34460-34469, 2013 | 62 | 2013 |
| Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3 JR Sutton, JR Blount, K Libohova, WL Tsou, GS Joshi, HL Paulson, ... Human molecular genetics 26 (8), 1419-1431, 2017 | 43 | 2017 |
| The social amoeba Dictyostelium discoideum is highly resistant to polyglutamine aggregation S Santarriaga, A Petersen, K Ndukwe, A Brandt, N Gerges, JB Scaglione, ... Journal of Biological Chemistry 290 (42), 25571-25578, 2015 | 35 | 2015 |
| Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP AJ Kanack, OJ Newsom, KM Scaglione Journal of Biological Chemistry 293 (8), 2735-2743, 2018 | 34 | 2018 |
| SCF E3-mediated autoubiquitination negatively regulates activity of Cdc34 E2 but plays a nonessential role in the catalytic cycle in vitro and in vivo KM Scaglione, PK Bansal, AE Deffenbaugh, A Kiss, JM Moore, S Korolev, ... Molecular and cellular biology 27 (16), 5860-5870, 2007 | 26 | 2007 |
