关注
Craig M. Goodwin
Craig M. Goodwin
在 med.unc.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
Drugging an undruggable pocket on KRAS
D Kessler, M Gmachl, A Mantoulidis, LJ Martin, A Zoephel, M Mayer, ...
Proceedings of the National Academy of Sciences 116 (32), 15823-15829, 2019
3882019
Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer
GA Hobbs, NM Baker, AM Miermont, RD Thurman, M Pierobon, TH Tran, ...
Cancer discovery 10 (1), 104-123, 2020
1672020
Discovery of 2-indole-acylsulfonamide myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods
NF Pelz, Z Bian, B Zhao, S Shaw, JC Tarr, J Belmar, C Gregg, ...
Journal of medicinal chemistry 59 (5), 2054-2066, 2016
1542016
Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer
CM Goodwin, OW Rossanese, ET Olejniczak, SW Fesik
Cell Death & Differentiation 22 (12), 2098-2106, 2015
1182015
Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design
JP Burke, Z Bian, S Shaw, B Zhao, CM Goodwin, J Belmar, CF Browning, ...
Journal of medicinal chemistry 58 (9), 3794-3805, 2015
1052015
Low-dose vertical inhibition of the RAF-MEK-ERK cascade causes apoptotic death of KRAS mutant cancers
I Ozkan-Dagliyan, JN Diehl, SD George, A Schaefer, B Papke, ...
Cell reports 31 (11), 2020
852020
Discovery and biological characterization of potent myeloid cell leukemia‐1 inhibitors
T Lee, Z Bian, B Zhao, LJ Hogdal, JL Sensintaffar, CM Goodwin, J Belmar, ...
FEBS letters 591 (1), 240-251, 2017
662017
Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer
CM Goodwin, AM Waters, JE Klomp, S Javaid, KL Bryant, CA Stalnecker, ...
Cancer research 83 (1), 141-157, 2023
542023
Concurrent inhibition of IGF1R and ERK increases pancreatic cancer sensitivity to autophagy inhibitors
CA Stalnecker, KR Grover, AC Edwards, MF Coleman, R Yang, ...
Cancer research 82 (4), 586-598, 2022
362022
Potential of chromium (III) picolinate for reproductive or developmental toxicity following exposure of male CD-1 mice prior to mating
DA McAdory, NR Rhodes, F Briggins, MM Bailey, KR Di Bona, C Goodwin, ...
Biological trace element research 143, 1666-1672, 2011
272011
CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
JE Klomp, YS Lee, CM Goodwin, B Papke, JA Klomp, AM Waters, ...
Cell reports 37 (9), 2021
232021
Functional and biological heterogeneity of KRASQ61 mutations
MV Huynh, GA Hobbs, A Schaefer, M Pierobon, LM Carey, JN Diehl, ...
Science signaling 15 (746), eabn2694, 2022
202022
Electronarcosis produced by a combination of direct and alternating current. A preliminary study: 1. apparatus and electrodes
RH Smith, C Goodwin, E Fowler, GW Smith, PP Volpitto
The Journal of the American Society of Anesthesiologists 22 (2), 163-168, 1961
201961
Targeting p130Cas-and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
AM Waters, TO Khatib, B Papke, CM Goodwin, GA Hobbs, JN Diehl, ...
Cell reports 35 (13), 2021
192021
Reply to Tran et al.: Dimeric KRAS protein–protein interaction stabilizers
D Kessler, A Gollner, M Gmachl, A Mantoulidis, LJ Martin, A Zoephel, ...
Proceedings of the National Academy of Sciences 117 (7), 3365-3367, 2020
152020
Concurrent inhibition of ERK and farnesyltransferase suppresses the growth of HRAS mutant head and neck squamous cell carcinoma
S Javaid, A Schaefer, CM Goodwin, VV Nguyen, FL Massey, M Pierobon, ...
Molecular cancer therapeutics 21 (5), 762-774, 2022
132022
Vertical Inhibition of the RAF–MEK–ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRASQ61X Mutant …
N Garcia, V Del Pozo, ME Yohe, CM Goodwin, TJ Shackleford, L Wang, ...
Molecular cancer therapeutics 21 (1), 170-183, 2022
122022
Targeting the ERK mitogen-activated protein kinase cascade for the treatment of KRAS-mutant pancreatic cancer
JN Diehl, PS Hibshman, I Ozkan-Dagliyan, CM Goodwin, SV Howard, ...
Advances in Cancer Research 153, 101-130, 2022
112022
Defining the KRAS-and ERK-dependent transcriptome in KRAS-mutant cancers
JA Klomp, JE Klomp, CA Stalnecker, KL Bryant, AC Edwards, ...
Science 384 (6700), eadk0775, 2024
62024
Detection of phenotype‐specific therapeutic vulnerabilities in breast cells using a CRISPR loss‐of‐function screen
A Barkovskaya, CM Goodwin, K Seip, B Hilmarsdottir, S Pettersen, ...
Molecular Oncology 15 (8), 2026-2045, 2021
52021
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