Structural understanding of interleukin 6 family cytokine signaling and targeted therapies: focus on interleukin 11 RD Metcalfe, TL Putoczki, MDW Griffin Frontiers in immunology 11, 1424, 2020 | 83 | 2020 |
Emerging roles for IL-11 in inflammatory diseases KY Fung, C Louis, RD Metcalfe, CC Kosasih, IP Wicks, MDW Griffin, ... Cytokine 149, 155750, 2022 | 41 | 2022 |
The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis SC Xie, RD Metcalfe, E Hanssen, T Yang, DL Gillett, AP Leis, CJ Morton, ... Nature microbiology 4 (11), 1990-2000, 2019 | 36 | 2019 |
The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement RD Metcalfe, K Aizel, CO Zlatic, PM Nguyen, CJ Morton, DSS Lio, ... Journal of Biological Chemistry 295 (24), 8285-8301, 2020 | 35 | 2020 |
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy SC Xie, RD Metcalfe, E Dunn, CJ Morton, SC Huang, T Puhalovich, Y Du, ... Science 376 (6597), 1074-1079, 2022 | 34 | 2022 |
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome SC Xie, RD Metcalfe, H Mizutani, T Puhalovich, E Hanssen, CJ Morton, ... Proceedings of the National Academy of Sciences 118 (39), e2107213118, 2021 | 22 | 2021 |
Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome YH Chen, DB Zastrow, RD Metcalfe, L Gartner, F Krause, CJ Morton, ... Journal of Allergy and Clinical Immunology 148 (2), 585-598, 2021 | 22 | 2021 |
Structural insights into the unique modes of relaxin-binding and tethered-agonist mediated activation of RXFP1 and RXFP2 A Sethi, S Bruell, T Ryan, F Yan, MH Tanipour, YF Mok, C Draper-Joyce, ... Journal of Molecular Biology 433 (21), 167217, 2021 | 9 | 2021 |
Molecular basis of functional effects of phosphorylation of the C-terminal domain of the rabies virus P protein J Zhan, E Watts, AM Brice, RD Metcalfe, AM Rozario, A Sethi, F Yan, ... Journal of Virology 96 (9), e00111-22, 2022 | 7 | 2022 |
Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant RD Metcalfe, E Hanssen, KY Fung, K Aizel, CC Kosasih, CO Zlatic, ... Nature Communications 14 (1), 7543, 2023 | 5* | 2023 |
Unravelling the Carbohydrate‐Binding Preferences of the Carbohydrate‐Binding Modules of AMP‐Activated Protein Kinase JI Mobbs, A Di Paolo, RD Metcalfe, E Selig, DI Stapleton, MDW Griffin, ... Chembiochem 19 (3), 229-238, 2018 | 4 | 2018 |
Structure and regulation of full-length human leucine-rich repeat kinase 1 RD Metcalfe, JA Martinez Fiesco, L Bonet-Ponce, JH Kluss, MR Cookson, ... Nature Communications 14 (1), 4797, 2023 | 2 | 2023 |
Cytokine Receptors and Their Ligands KSCT Shing, WL Kan, TL Nero, TR Hercus, D Tvorogov, RD Metcalfe, ... Encyclopedia of Cell Biology: Functional Aspects of Cell Biology-Part 1, 21-45, 2022 | 2 | 2022 |
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase SC Xie, Y Wang, CJ Morton, RD Metcalfe, C Dogovski, CFA Pasaje, ... Nature communications 15 (1), 937, 2024 | | 2024 |
A structural understanding of interleukin-11 signalling RD Metcalfe University of Melbourne, 2020 | | 2020 |