Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 13480* | 2021 |
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 J Kim, M Kundu, B Viollet, KL Guan Nature cell biology 13 (2), 132-141, 2011 | 7103 | 2011 |
TSC2 mediates cellular energy response to control cell growth and survival K Inoki, T Zhu, KL Guan Cell 115 (5), 577-590, 2003 | 4696 | 2003 |
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling K Inoki, Y Li, T Zhu, J Wu, KL Guan Nature cell biology 4 (9), 648-657, 2002 | 3796 | 2002 |
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control B Zhao, X Wei, W Li, RS Udan, Q Yang, J Kim, J Xie, T Ikenoue, J Yu, L Li, ... Genes & development 21 (21), 2747-2761, 2007 | 3133 | 2007 |
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases W Xu, H Yang, Y Liu, Y Yang, P Wang, SH Kim, S Ito, C Yang, P Wang, ... Cancer cell 19 (1), 17-30, 2011 | 3070 | 2011 |
TEAD mediates YAP-dependent gene induction and growth control B Zhao, X Ye, J Yu, L Li, W Li, S Li, J Yu, JD Lin, CY Wang, ... Genes & development 22 (14), 1962-1971, 2008 | 2464 | 2008 |
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling K Inoki, Y Li, T Xu, KL Guan Genes & development 17 (15), 1829-1834, 2003 | 2307 | 2003 |
Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase KL Guan, JE Dixon Analytical biochemistry 192 (2), 262-267, 1991 | 2276 | 1991 |
Regulation of cellular metabolism by protein lysine acetylation S Zhao, W Xu, W Jiang, W Yu, Y Lin, T Zhang, J Yao, L Zhou, Y Zeng, H Li, ... Science 327 (5968), 1000-1004, 2010 | 2080 | 2010 |
Hippo pathway in organ size control, tissue homeostasis, and cancer FX Yu, B Zhao, KL Guan Cell 163 (4), 811-828, 2015 | 2041 | 2015 |
mTOR: a pharmacologic target for autophagy regulation YC Kim, KL Guan The Journal of clinical investigation 125 (1), 25-32, 2015 | 1790 | 2015 |
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase RC Russell, Y Tian, H Yuan, HW Park, YY Chang, J Kim, H Kim, ... Nature cell biology 15 (7), 741-750, 2013 | 1727 | 2013 |
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling FX Yu, B Zhao, N Panupinthu, JL Jewell, I Lian, LH Wang, J Zhao, H Yuan, ... Cell 150 (4), 780-791, 2012 | 1675 | 2012 |
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth K Inoki, H Ouyang, T Zhu, C Lindvall, Y Wang, X Zhang, Q Yang, ... Cell 126 (5), 955-968, 2006 | 1599 | 2006 |
Regulation of TORC1 by Rag GTPases in nutrient response E Kim, P Goraksha-Hicks, L Li, TP Neufeld, KL Guan Nature cell biology 10 (8), 935-945, 2008 | 1554 | 2008 |
Mechanisms of Hippo pathway regulation Z Meng, T Moroishi, KL Guan Genes & development 30 (1), 1-17, 2016 | 1532 | 2016 |
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCFβ-TRCP B Zhao, L Li, K Tumaneng, CY Wang, KL Guan Genes & development 24 (1), 72-85, 2010 | 1455 | 2010 |
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α S Zhao, Y Lin, W Xu, W Jiang, Z Zha, P Wang, W Yu, Z Li, L Gong, Y Peng, ... Science 324 (5924), 261-265, 2009 | 1395 | 2009 |
The Hippo pathway: regulators and regulations FX Yu, KL Guan Genes & development 27 (4), 355-371, 2013 | 1338 | 2013 |