Field-deployable viral diagnostics using CRISPR-Cas13 C Myhrvold, CA Freije, JS Gootenberg, OO Abudayyeh, HC Metsky, ... Science 360 (6387), 444-448, 2018 | 1180 | 2018 |
Massively multiplexed nucleic acid detection with Cas13 CM Ackerman, C Myhrvold, SG Thakku, CA Freije, HC Metsky, DK Yang, ... Nature 582 (7811), 277-282, 2020 | 619 | 2020 |
Zika virus evolution and spread in the Americas HC Metsky, CB Matranga, S Wohl, SF Schaffner, CA Freije, SM Winnicki, ... Nature 546 (7658), 411-415, 2017 | 434 | 2017 |
Programmable inhibition and detection of RNA viruses using Cas13 CA Freije, C Myhrvold, CK Boehm, AE Lin, NL Welch, A Carter, ... Molecular cell 76 (5), 826-837. e11, 2019 | 369 | 2019 |
Genomic epidemiology reveals multiple introductions of Zika virus into the United States ND Grubaugh, JT Ladner, MUG Kraemer, G Dudas, AL Tan, ... Nature 546 (7658), 401-405, 2017 | 369 | 2017 |
CRISPR-based surveillance for COVID-19 using genomically-comprehensive machine learning design HC Metsky, CA Freije, TSF Kosoko-Thoroddsen, PC Sabeti, C Myhrvold BioRxiv, 2020.02. 26.967026, 2020 | 163* | 2020 |
Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time KG Barnes, AE Lachenauer, A Nitido, S Siddiqui, R Gross, B Beitzel, ... Nature communications 11 (1), 4131, 2020 | 142 | 2020 |
Capturing sequence diversity in metagenomes with comprehensive and scalable probe design HC Metsky, KJ Siddle, A Gladden-Young, J Qu, DK Yang, P Brehio, ... Nature Biotechnology 37 (2), 160, 2019 | 119 | 2019 |
Designing sensitive viral diagnostics with machine learning HC Metsky, NL Welch, PP Pillai, NJ Haradhvala, L Rumker, S Mantena, ... Nature Biotechnology 40 (7), 1123-1131, 2022 | 61* | 2022 |
Rapid detection of Powassan virus in a patient with encephalitis by metagenomic sequencing A Piantadosi, S Kanjilal, V Ganesh, A Khanna, EP Hyle, J Rosand, T Bold, ... Clinical Infectious Diseases 66 (5), 789-792, 2018 | 57 | 2018 |
Combining genomics and epidemiology to track mumps virus transmission in the United States S Wohl, HC Metsky, SF Schaffner, A Piantadosi, M Burns, JA Lewnard, ... PLoS Biology 18 (2), e3000611, 2020 | 45 | 2020 |
Automatic Learning of Morphological Variations for Handling Out-of-Vocabulary Terms in Urdu-English MT N Habash, H Metsky Proceedings of the 8th Conference of the Association for Machine Translation …, 2008 | 12 | 2008 |
The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response Y Botti-Lodovico, P Nair, D Nosamiefan, M Stremlau, S Schaffner, ... Viruses 13 (8), 1605, 2021 | 9 | 2021 |
Broad Institute viral-ngs: v1. 13.3 C Tomkins-Tinch, S Ye, H Metsky, I Jungreis, R Sealfon, X Yang, ... Zenodo. doi 10, 2016 | 7 | 2016 |
Capturing diverse microbial sequence with comprehensive and scalable probe design HC Metsky, KJ Siddle, A Gladden-Young, J Qu, DK Yang, P Brehio, ... bioRxiv, 279570, 2018 | 6 | 2018 |
Model-directed generation of CRISPR-Cas13a guide RNAs designs artificial sequences that improve nucleic acid detection S Mantena, PP Pillai, BA Petros, NL Welch, C Myhrvold, PC Sabeti, ... bioRxiv, 2023 | 4 | 2023 |
Sample analysis, presence determination of a target sequence H Metsky, A Gnirke, C Matranga, D Park, P Sabeti US Patent 11,332,783, 2022 | 4 | 2022 |
Crispr system based droplet diagnostic systems and methods CA Freije, C Myhrvold, H Metsky, P Sabeti, G Thakku, J Kehe, ... US Patent App. 17/294,179, 2022 | 3 | 2022 |
DESIGNING SENSITIVE, SPECIFIC, AND OPTIMALLY ACTIVE BINDING MOLECULES FOR DIAGNOSTICS AND THERAPEUTICS P Sabeti, H Metsky, C Myhrvold, N Haradhvala US Patent App. 17/065,504, 2021 | 1 | 2021 |
MULTIPLEXING HIGHLY EVOLVING VIRAL VARIANTS WITH SHERLOCK DETECTION METHOD CA Freije, C Myhrvold, H Metsky, P Sabeti US Patent App. 17/294,232, 2022 | | 2022 |