| Protective genes and pathways in Alzheimer’s disease: moving towards precision interventions M Seto, RL Weiner, L Dumitrescu, TJ Hohman Molecular neurodegeneration 16 (1), 29, 2021 | 82 | 2021 |
| Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia MR Wood, MJ Noetzel, BJ Melancon, MS Poslusney, KD Nance, ... ACS medicinal chemistry letters 8 (2), 233-238, 2017 | 59 | 2017 |
| Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs JL Engers, KA Bollinger, RL Weiner, AL Rodriguez, MF Long, MM Breiner, ... ACS medicinal chemistry letters 8 (9), 925-930, 2017 | 44 | 2017 |
| Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core KA Bollinger, AS Felts, CJ Brassard, JL Engers, AL Rodriguez, RL Weiner, ... ACS medicinal chemistry letters 8 (9), 919-924, 2017 | 36 | 2017 |
| Challenges in the development of an M4 PAM in vivo tool compound: the discovery of VU0467154 and unexpected DMPK profiles of close analogs MR Wood, MJ Noetzel, MS Poslusney, BJ Melancon, JC Tarr, A Lamsal, ... Bioorganic & medicinal chemistry letters 27 (2), 171-175, 2017 | 35 | 2017 |
| Challenges in the development of an M4 PAM preclinical candidate: the discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides JC Tarr, MR Wood, MJ Noetzel, JL Bertron, RL Weiner, AL Rodriguez, ... Bioorganic & medicinal chemistry letters 27 (13), 2990-2995, 2017 | 34 | 2017 |
| Discovery of a novel 2, 4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping MF Long, JL Engers, S Chang, X Zhan, RL Weiner, VB Luscombe, ... Bioorganic & medicinal chemistry letters 27 (22), 4999-5001, 2017 | 29 | 2017 |
| Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl) quinoline-3-carbonitrile core BR Bewley, PK Spearing, RL Weiner, VB Luscombe, X Zhan, S Chang, ... Bioorganic & medicinal chemistry letters 27 (18), 4274-4279, 2017 | 26 | 2017 |
| Foraging and Calling Behavior of Carolina chickadees (Poecile carolinensis) in Response to the Head Orientation of Potential Predators TM Freeberg, DL Book, RL Weiner Ethology 122 (1), 10-19, 2016 | 23 | 2016 |
| Pretreatment with human chorionic gonadotropin protects the neonatal brain against the effects of hypoxic-ischemic injury TZ Movsas, RL Weiner, MB Greenberg, DM Holtzman, R Galindo Frontiers in pediatrics 5, 232, 2017 | 21 | 2017 |
| TREM2 gene expression associations with Alzheimer’s disease neuropathology are region-specific: implications for cortical versus subcortical microglia RL Winfree, M Seto, L Dumitrescu, V Menon, P De Jager, Y Wang, ... Acta Neuropathologica 145 (6), 733-747, 2023 | 17 | 2023 |
| Biological correlates of elevated soluble TREM2 in cerebrospinal fluid RL Winfree, L Dumitrescu, K Blennow, H Zetterberg, KA Gifford, ... Neurobiology of aging 118, 88-98, 2022 | 14 | 2022 |
| Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl) piperazin-1-yl)-6-(piperidin-1-yl) pyridazines as novel, CNS penetrant pan-muscarinic antagonists AM Bender, RL Weiner, VB Luscombe, S Ajmera, HP Cho, S Chang, ... Bioorganic & medicinal chemistry letters 27 (15), 3576-3581, 2017 | 14 | 2017 |
| Ccl5 mediates proper wiring of feedforward and lateral inhibition pathways in the inner retina DAS Duncan, RL Weiner, C Weitlauf, ML Risner, AL Roux, ER Sanford, ... Frontiers in neuroscience 12, 702, 2018 | 7 | 2018 |
| RNASE6 is a novel modifier of APOE-ε4 effects on cognition M Seto, RL Weiner, L Dumitrescu, ER Mahoney, SL Hansen, V Janve, ... Neurobiology of aging 118, 66-76, 2022 | 5 | 2022 |
| Synthesis and evaluation of 4, 6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype AM Bender, RL Weiner, VB Luscombe, HP Cho, CM Niswender, ... Bioorganic & medicinal chemistry letters 27 (11), 2479-2483, 2017 | 3 | 2017 |
| Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology RL Winfree, E Nolan, L Dumitrescu, K Blennow, H Zetterberg, KA Gifford, ... Molecular Neurodegeneration 19 (1), 41, 2024 | 1 | 2024 |
| Elevated protease-activated receptor 4 (PAR4) gene expression in Alzheimer’s disease predicts cognitive decline RL Winfree, K Erreger, J Phillips, M Seto, Y Wang, JA Schneider, ... Neurobiology of Aging 140, 93-101, 2024 | | 2024 |
| Region‐Specific Associations of Human Astrocytic Endfoot Genes with Alzheimer’s Disease Neuropathology and Cognitive Decline J Phillips, M Seto, RL Winfree, Y Wang, JA Schneider, DAA Bennett, ... Alzheimer's & Dementia 19, e080239, 2023 | | 2023 |
| Deconvolving Cerebrospinal Fluid Soluble TREM2 Signal and Longitudinal Associations with Cognition RL Weiner, L Dumitrescu, K Blennow, H Zetterberg, KA Gifford, ... Alzheimer's & Dementia 18, e066836, 2022 | | 2022 |
