Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria VM Isabella, BN Ha, MJ Castillo, DJ Lubkowicz, SE Rowe, YA Millet, ... Nature biotechnology 36 (9), 857-864, 2018 | 487 | 2018 |
Developing a new class of engineered live bacterial therapeutics to treat human diseases MR Charbonneau, VM Isabella, N Li, CB Kurtz Nature Communications 11 (1), 1738, 2020 | 290 | 2020 |
Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity DS Leventhal, A Sokolovska, N Li, C Plescia, SA Kolodziej, CW Gallant, ... Nature communications 11 (1), 2739, 2020 | 281 | 2020 |
Metabolic modulation of tumours with engineered bacteria for immunotherapy FP Canale, C Basso, G Antonini, M Perotti, N Li, A Sokolovska, ... Nature 598 (7882), 662-666, 2021 | 274 | 2021 |
Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase DM Warui, N Li, H Nørgaard, C Krebs, JM Bollinger Jr, SJ Booker Journal of the American Chemical Society 133 (10), 3316-3319, 2011 | 171 | 2011 |
Conversion of fatty aldehydes to alka (e) nes and formate by a cyanobacterial aldehyde decarbonylase: cryptic redox by an unusual dimetal oxygenase N Li, H Nørgaard, DM Warui, SJ Booker, C Krebs, JM Bollinger Jr Journal of the American Chemical Society 133 (16), 6158-6161, 2011 | 159 | 2011 |
Evidence for only oxygenative cleavage of aldehydes to alk (a/e) nes and formate by cyanobacterial aldehyde decarbonylases N Li, W Chang, DM Warui, SJ Booker, C Krebs, JM Bollinger Jr Biochemistry 51 (40), 7908-7916, 2012 | 151 | 2012 |
A Long-Lived, Substrate-Hydroxylating Peroxodiiron(III/III) Intermediate in the Amine Oxygenase, AurF, from Streptomyces thioluteus VK Korboukh, N Li, EW Barr, JM Bollinger Jr, C Krebs Journal of the American Chemical Society 131 (38), 13608-13609, 2009 | 96 | 2009 |
Substrate-triggered addition of dioxygen to the diferrous cofactor of aldehyde-deformylating oxygenase to form a diferric-peroxide intermediate ME Pandelia, N Li, H Nørgaard, DM Warui, LJ Rajakovich, W Chang, ... Journal of the American Chemical Society 135 (42), 15801-15812, 2013 | 84 | 2013 |
Four-electron oxidation of p-hydroxylaminobenzoate to p-nitrobenzoate by a peroxodiferric complex in AurF from Streptomyces thioluteus N Li, VK Korboukh, C Krebs, JM Bollinger Jr Proceedings of the National Academy of Sciences 107 (36), 15722-15727, 2010 | 81 | 2010 |
Rapid reduction of the diferric-peroxyhemiacetal intermediate in aldehyde-deformylating oxygenase by a cyanobacterial ferredoxin: evidence for a free-radical mechanism LJ Rajakovich, H Nørgaard, DM Warui, W Chang, N Li, SJ Booker, ... Journal of the American Chemical Society 137 (36), 11695-11709, 2015 | 62 | 2015 |
Peroxide activation for electrophilic reactivity by the binuclear non-heme iron enzyme AurF K Park, N Li, Y Kwak, M Srnec, CB Bell, LV Liu, SD Wong, Y Yoda, S Kitao, ... Journal of the American Chemical Society 139 (20), 7062-7070, 2017 | 60 | 2017 |
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells LM Sanmarco, JM Rone, CM Polonio, G Fernandez Lahore, F Giovannoni, ... Nature, 1-9, 2023 | 28 | 2023 |
Novel approaches for the accumulation of oxygenated intermediates to multi-millimolar concentrations C Krebs, LMK Dassama, ML Matthews, W Jiang, JC Price, V Korboukh, ... Coordination chemistry reviews 257 (1), 234-243, 2013 | 25 | 2013 |
Receptor-associated protein (RAP) plays a central role in modulating Aβ deposition in APP/PS1 transgenic mice G Xu, C Karch, N Li, N Lin, D Fromholt, V Gonzales, DR Borchelt PLoS One 3 (9), e3159, 2008 | 16 | 2008 |
A distal enhancer controls cytokine-dependent human cPLA2α gene expression [S] JS Bickford, DE Beachy, KJ Newsom, SJ Barilovits, JDH Herlihy, X Qiu, ... Journal of lipid research 54 (7), 1915-1926, 2013 | 8 | 2013 |
Metabolic modulation of the tumor microenvironment using Synthetic Biotic™ Medicines KA West, A Fisher, D Leventhal, A Sokolovska, N Li, C Plescia, M Castillo, ... Cancer research 78 (13_Supplement), 2920-2920, 2018 | 7 | 2018 |
Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells D Falb, JW Kotula, VM Isabella, PF Miller, S Machinani, S Saha, AB Fisher, ... US Patent 11,471,494, 2022 | 6 | 2022 |
Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells AB FISHER, N Li, JM Lora | 5 | 2020 |
Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells D Falb, JW Kotula, VM Isabella, PF Miller, S Machinani, S Saha, AB Fisher, ... US Patent App. 17/879,559, 2023 | 2 | 2023 |