Alpha-synuclein and protein degradation systems: a reciprocal relationship M Xilouri, OR Brekk, L Stefanis Molecular neurobiology 47, 537-551, 2013 | 345 | 2013 |
Autophagy and A lpha‐S ynuclein: R elevance to P arkinson's D isease and R elated S ynucleopathies M Xilouri, OR Brekk, L Stefanis Movement Disorders 31 (2), 178-192, 2016 | 300 | 2016 |
Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration M Xilouri, OR Brekk, N Landeck, PM Pitychoutis, T Papasilekas, ... Brain 136 (7), 2130-2146, 2013 | 211 | 2013 |
Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats M Xilouri, OR Brekk, A Polissidis, M Chrysanthou-Piterou, I Kloukina, ... Autophagy 12 (11), 2230-2247, 2016 | 114 | 2016 |
Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain PJ Hallett, M Huebecker, OR Brekk, EB Moloney, EM Rocha, ... Neurobiology of aging 67, 189-200, 2018 | 80 | 2018 |
Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance OR Brekk, JR Honey, S Lee, PJ Hallett, O Isacson Proceedings of the National Academy of Sciences 117 (44), 27646-27654, 2020 | 67 | 2020 |
LAMP2A as a therapeutic target in Parkinson disease M Xilouri, OR Brekk, D Kirik, L Stefanis Autophagy 9 (12), 2166-2168, 2013 | 59 | 2013 |
Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age OR Brekk, A Moskites, O Isacson, PJ Hallett Scientific Reports 8 (1), 15207, 2018 | 27 | 2018 |
Novel results and concepts emerging from lipid cell biology relevant to degenerative brain aging and disease O Isacson, OR Brekk, PJ Hallett Frontiers in neurology 10, 1053, 2019 | 25 | 2019 |
Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity OR Brekk, JA Korecka, CC Crapart, M Huebecker, ZK MacBain, ... Acta Neuropathologica Communications 8, 1-14, 2020 | 24 | 2020 |
Impairment of chaperone-mediated autophagy affects neuronal homeostasis through altered expression of DJ-1 and CRMP-2 proteins OR Brekk, M Makridakis, P Mavroeidi, A Vlahou, M Xilouri, L Stefanis Molecular and Cellular Neuroscience 95, 1-12, 2019 | 14 | 2019 |
Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain R Thomas, KJ Connolly, OR Brekk, AJ Hinrich, ML Hastings, O Isacson, ... Scientific Reports 13 (1), 15164, 2023 | 2 | 2023 |
Pre-Clinical Studies Toward Autologous Midbrain Dopamine Cell Therapy for Parkinson's Disease T Osborn, D Dinesh, A Moskites, Z BacBain, M More, O Brekk, ... StemJournal, Abstract 3, 2020 | 2 | 2020 |
Induction of Chaperone-Mediated Autophagy as a Means to Attenuate Alpha-Synuclein-Mediated Neurotoxicity M Xilouri, O Brekk, N Landeck, T Papasilekas, T Pitichoutis, K Vekrellis, ... Catecholamine Research in the 21st Century, 128, 2013 | | 2013 |
Targeting the CMA pathway ameliorates alpha-synuclein mediated neurodegeneration M Xilouri, OR Brekk, P Themistoklis, K Vekrellis, L Stefanis MOVEMENT DISORDERS 27, S497-S498, 2012 | | 2012 |