关注
Oeystein Roed Brekk
Oeystein Roed Brekk
Sr. Scientist, Takeda
在 takeda.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Alpha-synuclein and protein degradation systems: a reciprocal relationship
M Xilouri, OR Brekk, L Stefanis
Molecular neurobiology 47, 537-551, 2013
3452013
Autophagy and A lpha‐S ynuclein: R elevance to P arkinson's D isease and R elated S ynucleopathies
M Xilouri, OR Brekk, L Stefanis
Movement Disorders 31 (2), 178-192, 2016
3002016
Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration
M Xilouri, OR Brekk, N Landeck, PM Pitychoutis, T Papasilekas, ...
Brain 136 (7), 2130-2146, 2013
2112013
Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats
M Xilouri, OR Brekk, A Polissidis, M Chrysanthou-Piterou, I Kloukina, ...
Autophagy 12 (11), 2230-2247, 2016
1142016
Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain
PJ Hallett, M Huebecker, OR Brekk, EB Moloney, EM Rocha, ...
Neurobiology of aging 67, 189-200, 2018
802018
Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance
OR Brekk, JR Honey, S Lee, PJ Hallett, O Isacson
Proceedings of the National Academy of Sciences 117 (44), 27646-27654, 2020
672020
LAMP2A as a therapeutic target in Parkinson disease
M Xilouri, OR Brekk, D Kirik, L Stefanis
Autophagy 9 (12), 2166-2168, 2013
592013
Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age
OR Brekk, A Moskites, O Isacson, PJ Hallett
Scientific Reports 8 (1), 15207, 2018
272018
Novel results and concepts emerging from lipid cell biology relevant to degenerative brain aging and disease
O Isacson, OR Brekk, PJ Hallett
Frontiers in neurology 10, 1053, 2019
252019
Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity
OR Brekk, JA Korecka, CC Crapart, M Huebecker, ZK MacBain, ...
Acta Neuropathologica Communications 8, 1-14, 2020
242020
Impairment of chaperone-mediated autophagy affects neuronal homeostasis through altered expression of DJ-1 and CRMP-2 proteins
OR Brekk, M Makridakis, P Mavroeidi, A Vlahou, M Xilouri, L Stefanis
Molecular and Cellular Neuroscience 95, 1-12, 2019
142019
Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain
R Thomas, KJ Connolly, OR Brekk, AJ Hinrich, ML Hastings, O Isacson, ...
Scientific Reports 13 (1), 15164, 2023
22023
Pre-Clinical Studies Toward Autologous Midbrain Dopamine Cell Therapy for Parkinson's Disease
T Osborn, D Dinesh, A Moskites, Z BacBain, M More, O Brekk, ...
StemJournal, Abstract 3, 2020
22020
Induction of Chaperone-Mediated Autophagy as a Means to Attenuate Alpha-Synuclein-Mediated Neurotoxicity
M Xilouri, O Brekk, N Landeck, T Papasilekas, T Pitichoutis, K Vekrellis, ...
Catecholamine Research in the 21st Century, 128, 2013
2013
Targeting the CMA pathway ameliorates alpha-synuclein mediated neurodegeneration
M Xilouri, OR Brekk, P Themistoklis, K Vekrellis, L Stefanis
MOVEMENT DISORDERS 27, S497-S498, 2012
2012
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