| Cellular uptake and trafficking of antisense oligonucleotides ST Crooke, S Wang, TA Vickers, W Shen, X Liang Nature biotechnology 35 (3), 230-237, 2017 | 496 | 2017 |
| Antisense technology: an overview and prospectus ST Crooke, BF Baker, RM Crooke, X Liang Nature reviews Drug discovery 20 (6), 427-453, 2021 | 417 | 2021 |
| trans and cis Splicing in Trypanosomatids: Mechanism, Factors, and Regulation X Liang, A Haritan, S Uliel, S Michaeli Eukaryotic cell 2 (5), 830-840, 2003 | 274 | 2003 |
| rRNA modifications in an intersubunit bridge of the ribosome strongly affect both ribosome biogenesis and activity X Liang, Q Liu, MJ Fournier Molecular cell 28 (6), 965-977, 2007 | 258 | 2007 |
| Loss of rRNA modifications in the decoding center of the ribosome impairs translation and strongly delays pre-rRNA processing X Liang, Q Liu, MJ Fournier Rna 15 (9), 1716-1728, 2009 | 253 | 2009 |
| Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index W Shen, CL De Hoyos, MT Migawa, TA Vickers, H Sun, A Low, TA Bell III, ... Nature biotechnology 37 (6), 640-650, 2019 | 248 | 2019 |
| RNase H1-dependent antisense oligonucleotides are robustly active in directing RNA cleavage in both the cytoplasm and the nucleus XH Liang, H Sun, JG Nichols, ST Crooke Molecular therapy 25 (9), 2075-2092, 2017 | 233 | 2017 |
| Antisense technology: A review ST Crooke, XH Liang, BF Baker, RM Crooke Journal of Biological Chemistry 296, 2021 | 222 | 2021 |
| Phosphorothioate modified oligonucleotide–protein interactions ST Crooke, TA Vickers, X Liang Nucleic acids research 48 (10), 5235-5253, 2020 | 216 | 2020 |
| Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages X Liang, H Sun, W Shen, ST Crooke Nucleic acids research 43 (5), 2927-2945, 2015 | 189 | 2015 |
| Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames XH Liang, W Shen, H Sun, MT Migawa, TA Vickers, ST Crooke Nature biotechnology 34 (8), 875-880, 2016 | 188 | 2016 |
| Nucleotide modifications in three functionally important regions of the Saccharomyces cerevisiae ribosome affect translation accuracy A Baudin-Baillieu, C Fabret, X Liang, D Piekna-Przybylska, MJ Fournier, ... Nucleic acids research 37 (22), 7665-7677, 2009 | 163 | 2009 |
| The spliced leader-associated RNA is a trypanosome-specific sn (o) RNA that has the potential to guide pseudouridine formation on the SL RNA. XH Liang, YX Xu, S Michaeli Rna 8 (2), 237-246, 2002 | 144 | 2002 |
| 2′-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF W Shen, X Liang, H Sun, ST Crooke Nucleic acids research 43 (9), 4569-4578, 2015 | 116 | 2015 |
| The helicase Has1p is required for snoRNA release from pre-rRNA X Liang, MJ Fournier Molecular and cellular biology 26 (20), 7437-7450, 2006 | 110 | 2006 |
| Antisense oligonucleotides targeting translation inhibitory elements in 5′ UTRs can selectively increase protein levels X Liang, H Sun, W Shen, S Wang, J Yao, MT Migawa, HH Bui, SS Damle, ... Nucleic acids research 45 (16), 9528-9546, 2017 | 103 | 2017 |
| Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function WF Lima, HM Murray, SS Damle, CE Hart, G Hung, CL De Hoyos, ... Nucleic acids research 44 (11), 5299-5312, 2016 | 103 | 2016 |
| Phosphorothioate oligonucleotides can displace NEAT1 RNA and form nuclear paraspeckle-like structures W Shen, X Liang, ST Crooke Nucleic acids research 42 (13), 8648-8662, 2014 | 100 | 2014 |
| Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins MT Migawa, W Shen, WB Wan, G Vasquez, ME Oestergaard, A Low, ... Nucleic acids research 47 (11), 5465-5479, 2019 | 92 | 2019 |
| A genome-wide analysis of C/D and H/ACA-like small nucleolar RNAs in Trypanosoma brucei reveals a trypanosome-specific pattern of rRNA modification XH Liang, S Uliel, A Hury, S Barth, T Doniger, R Unger, S Michaeli Rna 11 (5), 619-645, 2005 | 91 | 2005 |
