| A programmable dual-RNA–guided DNA endonuclease in adaptive bacterial immunity M Jinek, K Chylinski, I Fonfara, M Hauer, JA Doudna, E Charpentier science 337 (6096), 816-821, 2012 | 19191 | 2012 |
| The new frontier of genome engineering with CRISPR-Cas9 JA Doudna, E Charpentier Science 346 (6213), 1258096, 2014 | 7343 | 2014 |
| Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression LS Qi, MH Larson, LA Gilbert, JA Doudna, JS Weissman, AP Arkin, ... Cell 152 (5), 1173-1183, 2013 | 5667 | 2013 |
| CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes LA Gilbert, MH Larson, L Morsut, Z Liu, GA Brar, SE Torres, ... Cell 154 (2), 442-451, 2013 | 4241 | 2013 |
| CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity JS Chen, E Ma, LB Harrington, M Da Costa, X Tian, JM Palefsky, ... Science 360 (6387), 436-439, 2018 | 3283 | 2018 |
| CRISPR/Cas, the immune system of bacteria and archaea P Horvath, R Barrangou Science 327 (5962), 167-170, 2010 | 3265 | 2010 |
| RNA-programmed genome editing in human cells M Jinek, A East, A Cheng, S Lin, E Ma, J Doudna elife 2, e00471, 2013 | 2892 | 2013 |
| RNA-guided genetic silencing systems in bacteria and archaea B Wiedenheft, SH Sternberg, JA Doudna Nature 482 (7385), 331-338, 2012 | 2624 | 2012 |
| DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 SH Sternberg, S Redding, M Jinek, EC Greene, JA Doudna Biophysical Journal 106 (2), 695a, 2014 | 2303 | 2014 |
| CRISPR–Cas9 structures and mechanisms F Jiang, JA Doudna Annual review of biophysics 46, 505-529, 2017 | 2032 | 2017 |
| High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity V Pattanayak, S Lin, JP Guilinger, E Ma, JA Doudna, DR Liu Nature biotechnology 31 (9), 839-843, 2013 | 1884 | 2013 |
| Crystal structure of a group I ribozyme domain: principles of RNA packing JH Cate, AR Gooding, E Podell, K Zhou, BL Golden, CE Kundrot, ... Science 273 (5282), 1678-1685, 1996 | 1707 | 1996 |
| Structures of Cas9 endonucleases reveal RNA-mediated conformational activation M Jinek, F Jiang, DW Taylor, SH Sternberg, E Kaya, E Ma, C Anders, ... Science 343 (6176), 1247997, 2014 | 1514 | 2014 |
| Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery S Lin, BT Staahl, RK Alla, JA Doudna elife 3, e04766, 2014 | 1359 | 2014 |
| Structural basis for double-stranded RNA processing by Dicer IJ MacRae, K Zhou, F Li, A Repic, AN Brooks, WZ Cande, PD Adams, ... Science 311 (5758), 195-198, 2006 | 1303 | 2006 |
| Molecular mechanisms of RNA interference RC Wilson, JA Doudna Annual review of biophysics 42, 217-239, 2013 | 1302 | 2013 |
| CRISPR-Cas guides the future of genetic engineering GJ Knott, JA Doudna Science 361 (6405), 866-869, 2018 | 1284 | 2018 |
| Biology and applications of CRISPR systems: harnessing nature’s toolbox for genome engineering AV Wright, JK Nuñez, JA Doudna Cell 164 (1), 29-44, 2016 | 1175 | 2016 |
| Enhanced proofreading governs CRISPR–Cas9 targeting accuracy JS Chen, YS Dagdas, BP Kleinstiver, MM Welch, AA Sousa, ... Nature 550 (7676), 407-410, 2017 | 1137 | 2017 |
| Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection A East-Seletsky, MR O’Connell, SC Knight, D Burstein, JHD Cate, R Tjian, ... Nature 538 (7624), 270-273, 2016 | 1073 | 2016 |
