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Thomas O'Hara
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Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation
T O'Hara, L Virág, A Varró, Y Rudy
PLoS computational biology 7 (5), e1002061, 2011
13292011
Cardiac electrophysiological substrate underlying the ECG phenotype and electrogram abnormalities in Brugada syndrome patients
J Zhang, F Sacher, K Hoffmayer, T O’Hara, M Strom, P Cuculich, J Silva, ...
Circulation 131 (22), 1950-1959, 2015
1942015
Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome
H Sale, J Wang, TJ O'Hara, DJ Tester, P Phartiyal, JQ He, Y Rudy, ...
Circulation research 103 (7), e81-e95, 2008
1612008
Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species
T O'Hara, Y Rudy
American Journal of Physiology-Heart and Circulatory Physiology 302 (5 …, 2012
1602012
Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling
PT Wright, VO Nikolaev, T O'Hara, I Diakonov, A Bhargava, S Tokar, ...
Journal of molecular and cellular cardiology 67, 38-48, 2014
1322014
Simultaneous electrical recording of cardiac electrophysiology and contraction on chip
F Qian, C Huang, YD Lin, AN Ivanovskaya, TJ O'Hara, RH Booth, ...
Lab on a Chip 17 (10), 1732-1739, 2017
1192017
Microdomain-specific modulation of L-type calcium channels leads to triggered ventricular arrhythmia in heart failure
JL Sanchez-Alonso, A Bhargava, T O’Hara, AV Glukhov, ...
Circulation research 119 (8), 944-955, 2016
1192016
Early somatic mosaicism is a rare cause of long-QT syndrome
JR Priest, C Gawad, KM Kahlig, JK Yu, T O’Hara, PM Boyle, S Rajamani, ...
Proceedings of the National Academy of Sciences 113 (41), 11555-11560, 2016
512016
Arrhythmia formation in subclinical (“silent”) long QT syndrome requires multiple insults: quantitative mechanistic study using the KCNQ1 mutation Q357R as example
T O'Hara, Y Rudy
Heart Rhythm 9 (2), 275-282, 2012
502012
Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation
M Bébarová, T O'Hara, JLMC Geelen, RJ Jongbloed, C Timmermans, ...
American Journal of Physiology-Heart and Circulatory Physiology 295 (1), H48-H58, 2008
462008
Computational cardiology: how computer simulations could be used to develop new therapies and advance existing ones
NA Trayanova, T O'Hara, JD Bayer, PM Boyle, KS McDowell, ...
Europace 14 (suppl_5), v82-v89, 2012
422012
Dysfunction of the Voltage‐Gated K+ Channel β2 Subunit in a Familial Case of Brugada Syndrome
V Portero, S Le Scouarnec, Z Es‐Salah‐Lamoureux, S Burel, ...
Journal of the American Heart Association 5 (6), e003122, 2016
322016
Complex Brugada syndrome inheritance in a family harbouring compound SCN5A and CACNA1C mutations
DM Béziau, J Barc, T O’Hara, L Le Gloan, MY Amarouch, A Solnon, ...
Basic research in cardiology 109, 1-15, 2014
322014
Degradation of T-tubular microdomains and altered cAMP compartmentation lead to emergence of arrhythmogenic triggers in heart failure myocytes: an in silico study
AD Loucks, T O’Hara, NA Trayanova
Frontiers in Physiology 9, 1737, 2018
132018
Efficient computational modeling of human ventricular activation and its electrocardiographic representation: A sensitivity study
JP Cranford, TJ O’Hara, CT Villongco, OM Hafez, RC Blake, J Loscalzo, ...
Cardiovascular engineering and technology 9, 447-467, 2018
92018
Caveolin-3 and Caveolae regulate ventricular repolarization
YS Markandeya, ZR Gregorich, L Feng, V Ramchandran, T O'Hara, ...
Journal of molecular and cellular cardiology 177, 38-49, 2023
42023
Economical utilization of health information with learning healthcare system data commons
T O'Hara, A Saldanha, M Trunnell, RL Grossman, B Hota, ...
Perspectives in Health Information Management 19 (Spring), 2022
32022
Cardioid
J Cranford, D Richards, X Zhang, S Laudenschlager, J Glosli, T O'Hara, ...
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States), 2018
22018
Somatic Mosaicism of Novel SCN5A Mutation in Purkinje System (PS) may Underlie 2: 1 Block in an Infant with Long QT Syndrome (LQTS)
KY Joseph, PM Boyle, T O'Hara, JR Priest, E Ashley, NA Trayanova
Biophysical Journal 110 (3), 527a, 2016
22016
Cardiac-specific deletion of caveolin-3 delays repolarization and increases susceptibility to ventricular arrhythmia
YS Markandeya, L Feng, V Ramchandran, R Vaidyanathan, J Best, ...
Circulation 132 (suppl_3), A19749-A19749, 2015
22015
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