关注
Campbell McInnes
Campbell McInnes
Professor
在 cop.sc.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
Virtual screening strategies in drug discovery
C McInnes
Current opinion in chemical biology 11 (5), 494-502, 2007
5912007
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases
Z Xia, C Knaak, J Ma, ZM Beharry, C McInnes, W Wang, AS Kraft, ...
Journal of medicinal chemistry 52 (1), 74-86, 2008
2222008
2-Anilino-4-(thiazol-5-yl) pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity
S Wang, C Meades, G Wood, A Osnowski, S Anderson, R Yuill, M Thomas, ...
Journal of medicinal chemistry 47 (7), 1662-1675, 2004
1982004
Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding
S Uhrinova, D Uhrin, H Powers, K Watt, D Zheleva, P Fischer, C McInnes, ...
Journal of molecular biology 350 (3), 587-598, 2005
1872005
Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop
SY Wu, I McNae, G Kontopidis, SJ McClue, C McInnes, KJ Stewart, ...
Structure 11 (4), 399-410, 2003
1612003
Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design
G Kontopidis, SY Wu, DI Zheleva, P Taylor, C McInnes, DP Lane, ...
Proceedings of the National Academy of Sciences 102 (6), 1871-1876, 2005
1572005
4-[4-[(2-Hydroxybenzoyl) amino] phenyl] butyric acid as a novel oral delivery agent for recombinant human growth hormone
A Leone-Bay, KK Ho, R Agarwal, RA Baughman, K Chaudhary, ...
Journal of medicinal chemistry 39 (13), 2571-2578, 1996
1501996
Progress in the discovery of polo-like kinase inhibitors
C McInnes, M Mezna, PM Fischer
Current topics in medicinal chemistry 5 (2), 181-197, 2005
1482005
Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance
C McInnes, A Mazumdar, M Mezna, C Meades, C Midgley, F Scaerou, ...
Nature chemical biology 2 (11), 608, 2006
1332006
Discovery and characterization of 2-anilino-4-(thiazol-5-yl) pyrimidine transcriptional CDK inhibitors as anticancer agents
S Wang, G Griffiths, CA Midgley, AL Barnett, M Cooper, J Grabarek, ...
Chemistry & biology 17 (10), 1111-1121, 2010
1242010
Progress in the evaluation of CDK inhibitors as anti-tumor agents
C McInnes
Drug discovery today 13 (19-20), 875-881, 2008
1242008
PLK1 as an oncology target: current status and future potential
C McInnes, MD Wyatt
Drug discovery today 16 (13-14), 619-625, 2011
1212011
Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine Aurora Kinase Inhibitors
S Wang, CA Midgley, F Scaërou, JB Grabarek, G Griffiths, W Jackson, ...
Journal of medicinal chemistry 53 (11), 4367-4378, 2010
1172010
Growth factor receptors: structure, mechanism, and drug discovery
C McInnes, BD Sykes
Peptide Science 43 (5), 339-366, 1997
1121997
Highly potent p21WAF1‐derived peptide inhibitors of CDK‐mediated pRb phosphorylation: Delineation and structural insight into their interactions with cyclin A
DI Zheleva, C McInnes, AL Gavine, NZ Zhelev, PM Fischer, DP Lane
The Journal of peptide research 60 (5), 257-270, 2002
902002
Non-ATP competitive protein kinase inhibitors as anti-tumor therapeutics
LO Kirkland, C McInnes
Biochemical pharmacology 77 (10), 1561-1571, 2009
862009
Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes
MJI Andrews, C McInnes, G Kontopidis, L Innes, A Cowan, A Plater, ...
Organic & biomolecular chemistry 2 (19), 2735-2741, 2004
852004
Development of the structural basis for antimicrobial and hemolytic activities of peptides based on gramicidin S and design of novel analogs using NMR spectroscopy
C McInnes, LH Kondejewski, RS Hodges, BD Sykes
Journal of Biological Chemistry 275 (19), 14287-14294, 2000
842000
Insights into cyclin groove recognition: complex crystal structures and inhibitor design through ligand exchange
G Kontopidis, MJI Andrews, C McInnes, A Cowan, H Powers, L Innes, ...
Structure 11 (12), 1537-1546, 2003
812003
Strategies for the design of potent and selective kinase inhibitors
C McInnes, PM Fischer
Current pharmaceutical design 11 (14), 1845-1863, 2005
802005
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