| New potential binding determinant for hERG channel inhibitors P Saxena, EM Zangerl-Plessl, T Linder, A Windisch, A Hohaus, E Timin, ... Scientific reports 6, 24182, 2016 | 96 | 2016 |
| Experimentally validated hERG pharmacophore models as cardiotoxicity prediction tools JM Kratz, D Schuster, M Edtbauer, P Saxena, CE Mair, J Kirchebner, ... Journal of chemical information and modeling 54 (10), 2887-2901, 2014 | 65 | 2014 |
| Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo I Baburin, R Varkevisser, A Schramm, P Saxena, S Beyl, P Szkokan, ... Pharmacological research 131, 150-163, 2018 | 38 | 2018 |
| Human ether-à-go-go related gene (hERG) channel blocking aporphine alkaloids from lotus leaves and their quantitative analysis in dietary weight loss supplements U Grienke, CE Mair, P Saxena, I Baburin, O Scheel, M Ganzera, ... Journal of agricultural and food chemistry 63 (23), 5634-5639, 2015 | 33 | 2015 |
| hERG channel blocking ipecac alkaloids identified by combined in silico–in vitro screening JM Kratz, CE Mair, SK Oettl, P Saxena, O Scheel, D Schuster, S Hering, ... Planta medica 82 (11/12), 1009-1015, 2016 | 25 | 2016 |
| Natural products as potential human ether-a-go-go-related gene channel inhibitors–screening of plant-derived alkaloids A Schramm, P Saxena, J Chlebek, L Cahlíková, I Baburin, S Hering, ... Planta medica 80 (08/09), 740-746, 2014 | 24 | 2014 |
| Dynamic‐clamping human and rabbit atrial calcium current: narrowing ICaL window abolishes early afterdepolarisations S Kettlewell, P Saxena, J Dempster, MA Colman, RC Myles, GL Smith, ... The Journal of physiology, 2019 | 22 | 2019 |
| hERG Channel Inhibitory Daphnane Diterpenoid Orthoesters and Polycephalones A and B with Unprecedented Skeletons from Gnidia polycephala M De Mieri, K Du, M Neuburger, P Saxena, PC Zietsman, S Hering, ... Journal of natural products 78 (7), 1697-1707, 2015 | 22 | 2015 |
| The atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone AP Holmes, P Saxena, SN Kabir, C O’Shea, SM Kuhlmann, S Gupta, ... Heart Rhythm, 2021 | 14 | 2021 |
| Correlation between human ether‐a‐go‐go‐related gene channel inhibition and action potential prolongation P Saxena, MP Hortigon‐Vinagre, S Beyl, I Baburin, S Andranovits, ... British journal of pharmacology 174 (18), 3081-3093, 2017 | 14 | 2017 |
| Description of the human atrial action potential derived from a single, congruent data source: Novel computational models for integrated experimental-numerical study of atrial … MA Colman, P Saxena, S Kettlewell, AJ Workman Frontiers in physiology 9, 1211, 2018 | 10 | 2018 |
| Drug trapping in hERG K+ channels:(not) a matter of drug size? T Linder, H Bernsteiner, P Saxena, F Bauer, T Erker, E Timin, S Hering, ... MedChemComm 7 (3), 512-518, 2016 | 9 | 2016 |
| HPLC-Based activity profiling for Herg channel inhibitors in the South African medicinal plant Galenia africana K Du, M De Mieri, P Saxena, KV Phungula, A Wilhelm, MM Hrubaru, ... Planta medica 81 (12/13), 1154-1162, 2015 | 9 | 2015 |
| Structural Insights into Trapping and Dissociation of Small Molecules in K+ Channels T Linder, P Saxena, E Timin, S Hering, A Stary-Weinzinger Journal of chemical information and modeling 54 (11), 3218-3228, 2014 | 8 | 2014 |
| Inhibiting Runx1 protects heart function after myocardial infarction TP Martin, EA MacDonald, A Bradley, H Watson, P Saxena, ... bioRxiv, 2022.02. 17.480749, 2022 | 1 | 2022 |
| Adrenoceptor sub-type involvement in Ca2+ current stimulation by noradrenaline in human and rabbit atrial myocytes P Saxena, RC Myles, GL Smith, AJ Workman Pflügers Archiv-European Journal of Physiology 474 (12), 1311-1321, 2022 | | 2022 |
| Early Diastolic Ca2+ Sparks Alter Repolarization Rate of Rabbit Cardiomyocytes P Saxena, G Smith, N Macquaide Biophysical Journal 114 (3), 288a, 2018 | | 2018 |
| On the Relation between HERG Channel Block in Cell Line and Action Potential Prolongation in Human iPSC Cardiomyocytes P Saxena, M Hortigon-Vinagre, S Beyl, I Baburin, A Costa, AP IJzerman, ... Biophysical Journal 110 (3), 527a, 2016 | | 2016 |
| Comparison of HERG ion channel effects in HEK cells and action potential duration in human iPSC cardiomyocytes P Saxena, MP Hortigon-Vinagre, A Costa, E Timin, S Beyl, I Baburin, ... Journal of Pharmacological and Toxicological Methods 100 (81), 347, 2016 | | 2016 |
| HPLC-Based Activity Profiling for hERG Channel Inhibitors in the South African Medicinal Plant K Du, M De Mieri, P Saxena, KV Phungula, A Wilhelm, MM Hrubaru, ... | | 2015 |
Michael A ColmanUnivesity of Leeds在 leeds.ac.uk 的电子邮件经过验证
Michael A ColmanUnivesity of Leeds在 leeds.ac.uk 的电子邮件经过验证
Godfrey SmithUniversity of Glasgow在 glasgow.ac.uk 的电子邮件经过验证