An enhanced system for unnatural amino acid mutagenesis in E. coli TS Young, I Ahmad, JA Yin, PG Schultz Journal of molecular biology 395 (2), 361-374, 2010 | 785 | 2010 |
Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence BW Davies, RW Bogard, TS Young, JJ Mekalanos Cell 149 (2), 358-370, 2012 | 501 | 2012 |
Beyond the canonical 20 amino acids: expanding the genetic lexicon TS Young, PG Schultz Journal of Biological Chemistry 285 (15), 11039-11044, 2010 | 467 | 2010 |
Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies DT Rodgers, M Mazagova, EN Hampton, Y Cao, NS Ramadoss, IR Hardy, ... Proceedings of the National Academy of Sciences 113 (4), E459-E468, 2016 | 432 | 2016 |
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic EN Chin, C Yu, VF Vartabedian, Y Jia, M Kumar, AM Gamo, W Vernier, ... Science 369 (6506), 993-999, 2020 | 323 | 2020 |
Versatile strategy for controlling the specificity and activity of engineered T cells JSY Ma, JY Kim, SA Kazane, S Choi, HY Yun, MS Kim, DT Rodgers, ... Proceedings of the National Academy of Sciences 113 (4), E450-E458, 2016 | 309 | 2016 |
An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity DD Young, TS Young, M Jahnz, I Ahmad, G Spraggon, PG Schultz Biochemistry 50 (11), 1894-1900, 2011 | 243 | 2011 |
Redirection of genetically engineered CAR-T cells using bifunctional small molecules MS Kim, JSY Ma, H Yun, Y Cao, JY Kim, V Chi, D Wang, A Woods, ... Journal of the American Chemical Society 137 (8), 2832-2835, 2015 | 187 | 2015 |
Enhancing protein stability with extended disulfide bonds T Liu, Y Wang, X Luo, J Li, SA Reed, H Xiao, TS Young, PG Schultz Proceedings of the National Academy of Sciences 113 (21), 5910-5915, 2016 | 168 | 2016 |
Evolution of cyclic peptide protease inhibitors TS Young, DD Young, I Ahmad, JM Louis, SJ Benkovic, PG Schultz Proceedings of the National Academy of Sciences 108 (27), 11052-11056, 2011 | 147 | 2011 |
Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma D Raj, MH Yang, D Rodgers, EN Hampton, J Begum, A Mustafa, D Lorizio, ... Gut 68 (6), 1052-1064, 2019 | 138 | 2019 |
Ribosomal route to small-molecule diversity MDB Tianero, MS Donia, TS Young, PG Schultz, EW Schmidt Journal of the American Chemical Society 134 (1), 418-425, 2012 | 127 | 2012 |
Design of switchable chimeric antigen receptor T cells targeting breast cancer Y Cao, DT Rodgers, J Du, I Ahmad, EN Hampton, JSY Ma, M Mazagova, ... Angewandte Chemie International Edition 55 (26), 7520-7524, 2016 | 124 | 2016 |
An immunosuppressive antibody–drug conjugate RE Wang, T Liu, Y Wang, Y Cao, J Du, X Luo, V Deshmukh, CH Kim, ... Journal of the American Chemical Society 137 (9), 3229-3232, 2015 | 104 | 2015 |
Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans TS Young, CT Walsh Proceedings of the National Academy of Sciences 108 (32), 13053-13058, 2011 | 93 | 2011 |
Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors G Zhang, V Baidin, KS Pahil, E Moison, D Tomasek, NS Ramadoss, ... Proceedings of the National Academy of Sciences 115 (26), 6834-6839, 2018 | 90 | 2018 |
Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants TS Young, PC Dorrestein, CT Walsh Chemistry & biology 19 (12), 1600-1610, 2012 | 90 | 2012 |
Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory S Viaud, JSY Ma, IR Hardy, EN Hampton, B Benish, L Sherwood, ... Proceedings of the National Academy of Sciences 115 (46), E10898-E10906, 2018 | 87 | 2018 |
Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks CT Walsh, SJ Malcolmson, TS Young ACS Chemical Biology 7 (3), 429-442, 2012 | 79 | 2012 |
An anti-B cell maturation antigen bispecific antibody for multiple myeloma NS Ramadoss, AD Schulman, S Choi, DT Rodgers, SA Kazane, CH Kim, ... Journal of the American Chemical Society 137 (16), 5288-5291, 2015 | 78 | 2015 |