Oximes in organophosphate poisoning: 60 years of hope and despair F Worek, H Thiermann, T Wille Chemico-biological interactions 259, 93-98, 2016 | 184 | 2016 |
Organophosphorus compounds and oximes: a critical review F Worek, H Thiermann, T Wille Archives of Toxicology 94 (7), 2275-2292, 2020 | 161 | 2020 |
Toxicology of organophosphorus compounds in view of an increasing terrorist threat F Worek, T Wille, M Koller, H Thiermann Archives of toxicology 90, 2131-2145, 2016 | 129 | 2016 |
Improvement of the cold storage of blood vessels with a vascular preservation solution. Study in porcine aortic segments T Wille, H de Groot, U Rauen Journal of vascular surgery 47 (2), 422-431, 2008 | 80 | 2008 |
Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice KA Ziegler, A Ahles, T Wille, J Kerler, D Ramanujam, S Engelhardt Cardiovascular research 114 (2), 291-299, 2018 | 77 | 2018 |
Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro F Worek, T Seeger, M Goldsmith, Y Ashani, H Leader, JS Sussman, ... Archives of toxicology 88, 1257-1266, 2014 | 66 | 2014 |
Catalytic bioscavengers in nerve agent poisoning: A promising approach? F Worek, H Thiermann, T Wille Toxicology letters 244, 143-148, 2016 | 64 | 2016 |
Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase—Structure–activity relationships F Worek, T Wille, M Koller, H Thiermann Biochemical Pharmacology 83 (12), 1700-1706, 2012 | 59 | 2012 |
Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase F Worek, N Aurbek, T Wille, P Eyer, H Thiermann Toxicology letters 200 (1-2), 19-23, 2011 | 56 | 2011 |
Drug development for the management of organophosphorus poisoning PW Elsinghorst, F Worek, H Thiermann, T Wille Expert opinion on drug discovery 8 (12), 1467-1477, 2013 | 55 | 2013 |
Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase M Winter, T Wille, K Musilek, K Kuca, H Thiermann, F Worek Toxicology Letters 244, 136-142, 2016 | 52 | 2016 |
Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach F Worek, T Wille, N Aurbek, P Eyer, H Thiermann Toxicology and applied pharmacology 249 (3), 231-237, 2010 | 52 | 2010 |
Diagnostics and treatment of nerve agent poisoning—current status and future developments N Amend, KV Niessen, T Seeger, T Wille, F Worek, H Thiermann Annals of the New York Academy of Sciences 1479 (1), 13-28, 2020 | 50 | 2020 |
Detoxification of nerve agents by a substituted β-cyclodextrin: application of a modified biological assay T Wille, O Tenberken, G Reiter, S Müller, R Le Provost, O Lafont, F Estour, ... Toxicology 265 (3), 96-100, 2009 | 48 | 2009 |
On-site analysis of acetylcholinesterase and butyrylcholinesterase activity with the ChE check mobile test kit—determination of reference values and their relevance for … F Worek, M Schilha, K Neumaier, N Aurbek, T Wille, H Thiermann, K Kehe Toxicology letters 249, 22-28, 2016 | 42 | 2016 |
Effectiveness of a substituted β-cyclodextrin to prevent cyclosarin toxicity in vivo F Worek, T Seeger, M Zengerle, S Kubik, H Thiermann, T Wille Toxicology Letters 226 (2), 222-227, 2014 | 40 | 2014 |
Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase G Horn, T Wille, K Musilek, K Kuca, H Thiermann, F Worek Archives of toxicology 89, 405-414, 2015 | 38 | 2015 |
Optimized strategies to synthesize β-cyclodextrin-oxime conjugates as a new generation of organophosphate scavengers R Le Provost, T Wille, L Louise, N Masurier, S Müller, G Reiter, PY Renard, ... Organic & Biomolecular Chemistry 9 (8), 3026-3032, 2011 | 37 | 2011 |
Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: intraosseous versus intravenous injection T Wille, K Neumaier, M Koller, C Ehinger, N Aggarwal, Y Ashani, ... Toxicology Letters 258, 198-206, 2016 | 36 | 2016 |
New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: Evaluation of the detoxification using a half … RK Kalakuntla, T Wille, R Le Provost, S Letort, G Reiter, S Müller, ... Toxicology letters 216 (2-3), 200-205, 2013 | 34 | 2013 |