The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer AM Krebs, J Mitschke, M Lasierra Losada, O Schmalhofer, M Boerries, ... Nature cell biology 19 (5), 518-529, 2017 | 927 | 2017 |
Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss S Lucas, Y Omata, J Hofmann, M Böttcher, A Iljazovic, K Sarter, O Albrecht, ... Nature communications 9 (1), 55, 2018 | 547 | 2018 |
Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress D Mougiakakos, CC Johansson, R Jitschin, M Böttcher, R Kiessling Blood, The Journal of the American Society of Hematology 117 (3), 857-861, 2011 | 172 | 2011 |
The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts J Friščić, M Böttcher, C Reinwald, H Bruns, B Wirth, SJ Popp, KI Walker, ... Immunity 54 (5), 1002-1021. e10, 2021 | 157 | 2021 |
Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction C Wehmeyer, S Frank, D Beckmann, M Böttcher, C Cromme, U König, ... Science translational medicine 8 (330), 330ra35-330ra35, 2016 | 139 | 2016 |
Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3 J Boy, T Schmidt, H Wolburg, A Mack, S Nuber, M Böttcher, I Schmitt, ... Human molecular genetics 18 (22), 4282-4295, 2009 | 131 | 2009 |
D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization M Böttcher, K Renner, R Berger, K Mentz, S Thomas, ... Oncoimmunology 7 (7), e1445454, 2018 | 124 | 2018 |
Polyol pathway links glucose metabolism to the aggressiveness of cancer cells A Schwab, A Siddiqui, ME Vazakidou, F Napoli, M Böttcher, B Menchicchi, ... Cancer research 78 (7), 1604-1618, 2018 | 104 | 2018 |
The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia M Qorraj, H Bruns, M Böttcher, L Weigand, D Saul, A Mackensen, ... Leukemia 31 (2), 470-478, 2017 | 96 | 2017 |
IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation M Faas, N Ipseiz, J Ackermann, S Culemann, A Grüneboom, F Schröder, ... Immunity 54 (11), 2531-2546. e5, 2021 | 94 | 2021 |
IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner R Loschinski, M Böttcher, A Stoll, H Bruns, A Mackensen, D Mougiakakos Oncotarget 9 (17), 13125, 2018 | 89 | 2018 |
CLL-cell-mediated MDSC induction by exosomal miR-155 transfer is disrupted by vitamin D H Bruns, M Böttcher, M Qorraj, M Fabri, S Jitschin, J Dindorf, L Busch, ... Leukemia 31 (4), 985-988, 2017 | 82 | 2017 |
Inflammation-induced glycolytic switch controls suppressivity of mesenchymal stem cells via STAT1 glycosylation R Jitschin, M Böttcher, D Saul, S Lukassen, H Bruns, R Loschinski, ... Leukemia 33 (7), 1783-1796, 2019 | 73 | 2019 |
IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration U Kulkarni, CM Karsten, T Kohler, S Hammerschmidt, K Bommert, ... Journal of Allergy and Clinical Immunology 137 (5), 1487-1497. e6, 2016 | 73 | 2016 |
β2-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression D Hofbauer, D Mougiakakos, L Broggini, M Zaiss, M Büttner-Herold, ... Immunity 54 (8), 1772-1787. e9, 2021 | 69 | 2021 |
In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy B Kravic, AB Harbauer, V Romanello, L Simeone, FN Vögtle, T Kaiser, ... Autophagy 14 (2), 311-335, 2018 | 60 | 2018 |
Mesenchymal stromal cells disrupt mTOR‐signaling and aerobic glycolysis during T‐cell activation M Böttcher, A D. Hofmann, H Bruns, M Haibach, R Loschinski, D Saul, ... Stem Cells 34 (2), 516-521, 2016 | 54 | 2016 |
Interleukin-17A is involved in mechanical hyperalgesia but not in the severity of murine antigen-induced arthritis M Ebbinghaus, G Natura, G Segond von Banchet, S Hensellek, ... Scientific reports 7 (1), 10334, 2017 | 45 | 2017 |
Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia J Lu, E Cannizzaro, F Meier-Abt, S Scheinost, PM Bruch, HAR Giles, ... Nature Cancer 2 (8), 853-864, 2021 | 44 | 2021 |
Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis J Taubmann, B Krishnacoumar, C Böhm, M Faas, DIH Müller, S Adam, ... Scientific Reports 10 (1), 21020, 2020 | 41 | 2020 |