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Digant Nayak
Digant Nayak
Postdoc at University of Texas Health Science Centre, San Antonio
在 uthscsa.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design
W Rut, Z Lv, M Zmudzinski, S Patchett, D Nayak, SJ Snipas, F El Oualid, ...
Science advances 6 (42), eabd4596, 2020
406*2020
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity
D Lv, P Pal, X Liu, Y Jia, D Thummuri, P Zhang, W Hu, J Pei, Q Zhang, ...
Nature communications 12 (1), 6896, 2021
57*2021
Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase
M Zmudzinski, W Rut, K Olech, J Granda, M Giurg, M Burda-Grabowska, ...
Scientific Reports 13 (1), 9161, 2023
28*2023
Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination
D Nayak, J Sivaraman
Oncotarget 6 (33), 34342, 2015
242015
Structure of ScpC, a virulence protease from Streptococcus pyogenes, reveals the functional domains and maturation mechanism
C Jobichen, YC Tan, MT Prabhakar, D Nayak, D Biswas, NS Pannu, ...
Biochemical Journal 475 (17), 2847-2860, 2018
192018
Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activities in vitro
S Singh, J Ng, D Nayak, J Sivaraman
Journal of Biological Chemistry 294 (52), 19934-19949, 2019
172019
Structure of LNX1: Ubc13~ ubiquitin complex reveals the role of additional motifs for the E3 ligase activity of LNX1
D Nayak, J Sivaraman
Journal of molecular biology 430 (8), 1173-1188, 2018
122018
Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts
DJ Strub, M Talma, M Strub, W Rut, M Zmudzinski, W Brud, J Neyts, ...
Scientific reports 12 (1), 14230, 2022
102022
A novel encystation specific protein kinase regulates chitin synthesis in Entamoeba invadens
SK Samanta, SS Varghese, D Krishnan, M Baidya, D Nayak, S Mukherjee, ...
Molecular and biochemical parasitology 220, 19-27, 2018
62018
Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6
L Yuan, F Gao, Z Lv, D Nayak, A Nayak, P Santos Bury, KE Cano, L Jia, ...
Nature communications 13 (1), 4880, 2022
42022
Structure of Aedes aegypti procarboxypeptidase B1 and its binding with Dengue virus for controlling infection
E Gavor, YK Choong, NK Tulsian, D Nayak, F Idris, H Sivaraman, ...
Life Science Alliance 5 (1), 2022
22022
Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer
M Afsar, GQ Liu, L Jia, EA Ruben, D Nayak, Z Sayyad, PS Bury, KE Cano, ...
Nature communications 14 (1), 4786, 2023
2023
Characterization of the Ubiquitin and ISG15 Deconjugase Activity of SARS-CoV-1 and SARS-CoV-2 Papain-Like Protease
D Nayak, P dos Santos Bury, M Drag, AN Nijkerk, F El Oualid, SK Olsen
Deubiquitinases: Methods and Protocols, 171-188, 2022
2022
Clearing the air: Uniquely engaging furin as an approach to cystic fibrosis therapy
D Nayak, EV Wasmuth, SK Olsen
Cell chemical biology 29 (6), 927-929, 2022
2022
Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases-PLpro and Mpro in in vitro studies (preprint)
M Zmudzinski, W Rut, K Olech, J Granda, M Giurg, M Burda-Grabowska, ...
2020
UBIQUITINATION MECHANISM OF RING TYPE E3 LIGASE LIGAND OF NUMB PROTEIN X AND THEIR STRUCTURAL STUDIES
D NAYAK
2016
Supplementary Information Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7 …
M Zmudzinski, W Rut, K Olech, J Granda, M Giurg, M Burda-Grabowska, ...
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