Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 D Huangfu, K Osafune, R Maehr, W Guo, A Eijkelenboom, S Chen, ... Nature biotechnology 26 (11), 1269-1275, 2008 | 1910 | 2008 |
Generation of pluripotent stem cells from patients with type 1 diabetes R Maehr, S Chen, M Snitow, T Ludwig, L Yagasaki, R Goland, RL Leibel, ... Proceedings of the National Academy of Sciences 106 (37), 15768-15773, 2009 | 809 | 2009 |
A human pluripotent stem cell-based platform to study SARS-CoV-2 tropism and model virus infection in human cells and organoids L Yang, Y Han, BE Nilsson-Payant, V Gupta, P Wang, X Duan, X Tang, ... Cell stem cell 27 (1), 125-136. e7, 2020 | 673 | 2020 |
A small molecule that directs differentiation of human ESCs into the pancreatic lineage S Chen, M Borowiak, JL Fox, R Maehr, K Osafune, L Davidow, K Lam, ... Nature chemical biology 5 (4), 258-265, 2009 | 614 | 2009 |
Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions S Yao, S Chen, J Clark, E Hao, GM Beattie, A Hayek, S Ding Proceedings of the National Academy of Sciences 103 (18), 6907-6912, 2006 | 608 | 2006 |
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells M Borowiak, R Maehr, S Chen, AE Chen, W Tang, JL Fox, SL Schreiber, ... Cell stem cell 4 (4), 348-358, 2009 | 535 | 2009 |
Genetic incorporation of unnatural amino acids into proteins in mammalian cells W Liu, A Brock, S Chen, S Chen, PG Schultz Nature methods 4 (3), 239-244, 2007 | 534 | 2007 |
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids Y Han, X Duan, L Yang, BE Nilsson-Payant, P Wang, F Duan, X Tang, ... Nature 589 (7841), 270-275, 2021 | 480 | 2021 |
Dedifferentiation of lineage-committed cells by a small molecule S Chen, Q Zhang, X Wu, PG Schultz, S Ding Journal of the American Chemical Society 126 (2), 410-411, 2004 | 405 | 2004 |
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/β-catenin pathway Y Qyang, S Martin-Puig, M Chiravuri, S Chen, H Xu, L Bu, X Jiang, L Lin, ... Cell stem cell 1 (2), 165-179, 2007 | 393 | 2007 |
Self-renewal of embryonic stem cells by a small molecule S Chen, JT Do, Q Zhang, S Yao, F Yan, EC Peters, HR Schöler, ... Proceedings of the National Academy of Sciences 103 (46), 17266-17271, 2006 | 387 | 2006 |
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing M Crespo, E Vilar, SY Tsai, K Chang, S Amin, T Srinivasan, T Zhang, ... Nature medicine 23 (7), 878-884, 2017 | 354 | 2017 |
High-content screening in hPSC-neural progenitors identifies drug candidates that inhibit Zika virus infection in fetal-like organoids and adult brain T Zhou, L Tan, GY Cederquist, Y Fan, BJ Hartley, S Mukherjee, ... Cell stem cell 21 (2), 274-283. e5, 2017 | 242 | 2017 |
A modular platform for differentiation of human PSCs into all major ectodermal lineages J Tchieu, B Zimmer, F Fattahi, S Amin, N Zeltner, S Chen, L Studer Cell stem cell 21 (3), 399-410. e7, 2017 | 204 | 2017 |
SARS-CoV-2 infection induces beta cell transdifferentiation X Tang, S Uhl, T Zhang, D Xue, B Li, JJ Vandana, JA Acklin, ... Cell metabolism 33 (8), 1577-1591. e7, 2021 | 167 | 2021 |
Genome editing in hPSCs reveals GATA6 haploinsufficiency and a genetic interaction with GATA4 in human pancreatic development ZD Shi, K Lee, D Yang, S Amin, N Verma, QV Li, Z Zhu, CL Soh, R Kumar, ... Cell stem cell 20 (5), 675-688. e6, 2017 | 160 | 2017 |
Reversine increases the plasticity of lineage-committed mammalian cells S Chen, S Takanashi, Q Zhang, W Xiong, S Zhu, EC Peters, S Ding, ... Proceedings of the National Academy of Sciences 104 (25), 10482-10487, 2007 | 128 | 2007 |
An isogenic human ESC platform for functional evaluation of genome-wide-association-study-identified diabetes genes and drug discovery H Zeng, M Guo, T Zhou, L Tan, CN Chong, T Zhang, X Dong, JZ Xiang, ... Cell stem cell 19 (3), 326-340, 2016 | 127 | 2016 |
Genome-scale screens identify JNK–JUN signaling as a barrier for pluripotency exit and endoderm differentiation QV Li, G Dixon, N Verma, BP Rosen, M Gordillo, R Luo, C Xu, Q Wang, ... Nature genetics 51 (6), 999-1010, 2019 | 106 | 2019 |
Human organoid models to study SARS-CoV-2 infection Y Han, L Yang, LA Lacko, S Chen Nature Methods 19 (4), 418-428, 2022 | 101 | 2022 |