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The mitochondrial calcium uniporter selectively matches metabolic output to acute contractile stress in the heart JQ Kwong, X Lu, RN Correll, JA Schwanekamp, RJ Vagnozzi, MA Sargent, ... Cell reports 12 (1), 15-22, 2015 | 358 | 2015 |
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo NH Purcell, BJ Wilkins, A York, MK Saba-El-Leil, S Meloche, J Robbins, ... Proceedings of the National Academy of Sciences 104 (35), 14074-14079, 2007 | 305 | 2007 |
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Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart J Heineke, M Auger-Messier, J Xu, T Oka, MA Sargent, A York, R Klevitsky, ... The Journal of clinical investigation 117 (11), 3198-3210, 2007 | 288 | 2007 |
Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure J Heineke, M Auger-Messier, J Xu, M Sargent, A York, S Welle, ... Circulation 121 (3), 419-425, 2010 | 286 | 2010 |
A tension-based model distinguishes hypertrophic versus dilated cardiomyopathy J Davis, LC Davis, RN Correll, CA Makarewich, JA Schwanekamp, ... Cell 165 (5), 1147-1159, 2016 | 247 | 2016 |
DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility M Maillet, NH Purcell, MA Sargent, AJ York, OF Bueno, JD Molkentin Journal of Biological Chemistry 283 (45), 31246-31255, 2008 | 207 | 2008 |
Decreased cardiac L-type Ca2+ channel activity induces hypertrophy and heart failure in mice SA Goonasekera, K Hammer, M Auger-Messier, I Bodi, X Chen, H Zhang, ... The Journal of clinical investigation 122 (1), 280-290, 2012 | 198 | 2012 |
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The transcription factor GATA-6 regulates pathological cardiac hypertrophy JH Van Berlo, JW Elrod, MMG Van Den Hoogenhof, AJ York, BJ Aronow, ... Circulation research 107 (8), 1032-1040, 2010 | 110 | 2010 |
Genetic analysis of connective tissue growth factor as an effector of transforming growth factor β signaling and cardiac remodeling F Accornero, JH van Berlo, RN Correll, JW Elrod, MA Sargent, A York, ... Molecular and cellular biology 35 (12), 2154-2164, 2015 | 100 | 2015 |
Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents X Wu, B Chang, NS Blair, M Sargent, AJ York, J Robbins, GE Shull, ... The Journal of clinical investigation 119 (4), 976-985, 2009 | 98 | 2009 |
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Cdc42 is an antihypertrophic molecular switch in the mouse heart M Maillet, JM Lynch, B Sanna, AJ York, Y Zheng, JD Molkentin The Journal of clinical investigation 119 (10), 3079-3088, 2009 | 83 | 2009 |
Heart-specific Deletion of CnB1 Reveals Multiple Mechanisms Whereby Calcineurin Regulates Cardiac Growth and Function*♦ M Maillet, J Davis, M Auger-Messier, A York, H Osinska, J Piquereau, ... Journal of Biological Chemistry 285 (9), 6716-6724, 2010 | 72 | 2010 |
Inducible and myocyte-specific inhibition of PKCα enhances cardiac contractility and protects against infarction-induced heart failure M Hambleton, A York, MA Sargent, RA Kaiser, JN Lorenz, J Robbins, ... American Journal of Physiology-Heart and Circulatory Physiology 293 (6 …, 2007 | 70 | 2007 |
DUSP8 regulates cardiac ventricular remodeling by altering ERK1/2 signaling R Liu, JH van Berlo, AJ York, RJ Vagnozzi, M Maillet, JD Molkentin Circulation research 119 (2), 249-260, 2016 | 69 | 2016 |
Calcineurin protects the heart in a murine model of dilated cardiomyopathy J Heineke, KC Wollert, H Osinska, MA Sargent, AJ York, J Robbins, ... Journal of molecular and cellular cardiology 48 (6), 1080-1087, 2010 | 59 | 2010 |
Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations R Liu, RN Correll, J Davis, RJ Vagnozzi, AJ York, MA Sargent, AC Nairn, ... Journal of molecular and cellular cardiology 87, 204-213, 2015 | 53 | 2015 |