Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia‐reperfusion injury: therapeutic potential of synthetic Apelin analogues W Wang, SMK McKinnie, VB Patel, G Haddad, Z Wang, P Zhabyeyev, ... Journal of the American Heart Association 2 (4), e000249, 2013 | 234 | 2013 |
Angiotensin-converting enzyme 2 metabolizes and partially inactivates pyr-apelin-13 and apelin-17: physiological effects in the cardiovascular system W Wang, SMK McKinnie, M Farhan, M Paul, T McDonald, B McLean, ... Hypertension 68 (2), 365-377, 2016 | 226 | 2016 |
Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom JK Brunson, SMK McKinnie, JR Chekan, JP McCrow, ZD Miles, ... Science 361 (6409), 1356-1358, 2018 | 144 | 2018 |
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases JC Zhong, ZZ Zhang, W Wang, SMK McKinnie, JC Vederas, GY Oudit Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (8 …, 2017 | 115 | 2017 |
Guanitoxin, re-naming a cyanobacterial organophosphate toxin MF Fiore, ST de Lima, WW Carmichael, SMK McKinnie, JR Chekan, ... Harmful Algae 92, 101737, 2020 | 79 | 2020 |
The metalloprotease neprilysin degrades and inactivates apelin peptides SMK McKinnie, C Fischer, KMH Tran, W Wang, F Mosquera, GY Oudit, ... ChemBioChem 17 (16), 1495-1498, 2016 | 77 | 2016 |
Solid‐supported synthesis and biological evaluation of the lantibiotic peptide bis (desmethyl) lacticin 3147 A2 VR Pattabiraman, SMK McKinnie, JC Vederas Angewandte Chemie International Edition 47 (49), 9472-9475, 2008 | 70 | 2008 |
Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage ZR Li, J Li, W Cai, JYH Lai, SMK McKinnie, WP Zhang, BS Moore, ... Nature chemistry 11 (10), 880-889, 2019 | 68 | 2019 |
The synthesis of active and stable diaminopimelate analogues of the lantibiotic peptide lactocin S AC Ross, SMK McKinnie, JC Vederas Journal of the American Chemical Society 134 (4), 2008-2011, 2012 | 68 | 2012 |
Meroterpenoid natural products from Streptomyces bacteria–the evolution of chemoenzymatic syntheses LAM Murray, SMK McKinnie, BS Moore, JH George Natural product reports 37 (10), 1334-1366, 2020 | 57 | 2020 |
Scalable biosynthesis of the seaweed neurochemical, kainic acid JR Chekan, SMK McKinnie, ML Moore, SG Poplawski, TP Michael, ... Angewandte Chemie International Edition 58 (25), 8454-8457, 2019 | 54 | 2019 |
Total enzyme syntheses of napyradiomycins A1 and B1 SMK McKinnie, ZD Miles, PA Jordan, T Awakawa, HP Pepper, ... Journal of the American Chemical Society 140 (51), 17840-17845, 2018 | 51 | 2018 |
Cariogenic Streptococcus mutans Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization X Tang, Y Kudo, JL Baker, S LaBonte, PA Jordan, SMK McKinnie, J Guo, ... ACS infectious diseases 6 (4), 563-571, 2020 | 47 | 2020 |
Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl-and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents C Fischer, T Lamer, W Wang, SMK McKinnie, X Iturrioz, C Llorens-Cortes, ... European journal of medicinal chemistry 166, 119-124, 2019 | 46 | 2019 |
Synthetic modification within the “RPRL” region of apelin peptides: impact on cardiovascular activity and stability to neprilysin and plasma degradation SMK McKinnie, W Wang, C Fischer, T McDonald, KR Kalin, X Iturrioz, ... Journal of medicinal chemistry 60 (14), 6408-6427, 2017 | 45 | 2017 |
Comparative Genomics and Metabolomics in the Genus Nocardia D Männle, SMK McKinnie, SS Mantri, K Steinke, Z Lu, BS Moore, ... Msystems 5 (3), 10.1128/msystems. 00125-20, 2020 | 41 | 2020 |
Biosynthesis of l‐4‐Chlorokynurenine, an Antidepressant Prodrug and a Non‐Proteinogenic Amino Acid Found in Lipopeptide Antibiotics H Luhavaya, R Sigrist, JR Chekan, SMK McKinnie, BS Moore Angewandte Chemie International Edition 58 (25), 8394-8399, 2019 | 41 | 2019 |
Total synthesis establishes the biosynthetic pathway to the naphterpin and marinone natural products LAM Murray, SMK McKinnie, HP Pepper, R Erni, ZD Miles, ... Angewandte Chemie International Edition 57 (34), 11009-11014, 2018 | 40 | 2018 |
Characterization and biochemical assays of Streptomyces vanadium-dependent chloroperoxidases SMK McKinnie, ZD Miles, BS Moore Methods in enzymology 604, 405-424, 2018 | 27 | 2018 |
Biosynthesis of guanitoxin enables global environmental detection in freshwater cyanobacteria ST Lima, TR Fallon, JL Cordoza, JR Chekan, E Delbaje, AR Hopiavuori, ... Journal of the American Chemical Society 144 (21), 9372-9379, 2022 | 24 | 2022 |