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Prson Gautam, PhD
Prson Gautam, PhD
Visiting Researcher, Institute for Molecular Medicine Finland, University of Helsinki
在 helsinki.fi 的电子邮件经过验证
标题
引用次数
引用次数
年份
Endothelial destabilization by angiopoietin-2 via integrin β1 activation
L Hakanpaa, T Sipila, VM Leppanen, P Gautam, H Nurmi, G Jacquemet, ...
Nature communications 6 (1), 5962, 2015
2842015
Long-term ERK inhibition in KRAS-mutant pancreatic cancer is associated with MYC degradation and senescence-like growth suppression
TK Hayes, NF Neel, C Hu, P Gautam, M Chenard, B Long, M Aziz, ...
Cancer cell 29 (1), 75-89, 2016
2392016
Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer
GA Hobbs, NM Baker, AM Miermont, RD Thurman, M Pierobon, TH Tran, ...
Cancer discovery 10 (1), 104-123, 2020
1652020
KRAS suppression-induced degradation of MYC is antagonized by a MEK5-ERK5 compensatory mechanism
AV Vaseva, DR Blake, TSK Gilbert, S Ng, G Hostetter, SH Azam, ...
Cancer cell 34 (5), 807-822. e7, 2018
1562018
Prediction of drug combination effects with a minimal set of experiments
A Ianevski, AK Giri, P Gautam, A Kononov, S Potdar, J Saarela, ...
Nature machine intelligence 1 (12), 568-577, 2019
1302019
Drug target commons: a community effort to build a consensus knowledge base for drug-target interactions
J Tang, B Ravikumar, Z Alam, A Rebane, M Vähä-Koskela, G Peddinti, ...
Cell chemical biology 25 (2), 224-229. e2, 2018
1302018
Genomic perturbations reveal distinct regulatory networks in intrahepatic cholangiocarcinoma
C Nepal, CJ O'Rourke, DVNP Oliveira, A Taranta, S Shema, P Gautam, ...
Hepatology 68 (3), 949-963, 2018
1252018
Risk of handling paper currency in circulation chances of potential bacterial transmittance
J Lamichhane, S Adhikary, P Gautam, R Maharjan, B Dhakal
Nepal Journal of Science and Technology 10, 161-166, 2009
1092009
Bioluminescent, nonlytic, real-time cell viability assay and use in inhibitor screening
SJ Duellman, W Zhou, P Meisenheimer, G Vidugiris, JJ Cali, P Gautam, ...
Assay and drug development technologies 13 (8), 456-465, 2015
1032015
Consistency in drug response profiling
JP Mpindi, B Yadav, P Östling, P Gautam, D Malani, A Murumägi, ...
Nature 540 (7631), E5-E6, 2016
982016
Leveraging multi-way interactions for systematic prediction of pre-clinical drug combination effects
H Julkunen, A Cichonska, P Gautam, S Szedmak, J Douat, T Pahikkala, ...
Nature communications 11 (1), 6136, 2020
862020
Low-dose vertical inhibition of the RAF-MEK-ERK cascade causes apoptotic death of KRAS mutant cancers
I Ozkan-Dagliyan, JN Diehl, SD George, A Schaefer, B Papke, ...
Cell reports 31 (11), 2020
842020
Rational polypharmacology: systematically identifying and engaging multiple drug targets to promote axon growth
H Al-Ali, DH Lee, MC Danzi, H Nassif, P Gautam, K Wennerberg, ...
ACS chemical biology 10 (8), 1939-1951, 2015
722015
Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells
P Gautam, L Karhinen, A Szwajda, SK Jha, B Yadav, T Aittokallio, ...
Molecular cancer 15, 1-16, 2016
712016
Donor simvastatin treatment prevents ischemia-reperfusion and acute kidney injury by preserving microvascular barrier function
R Tuuminen, AI Nykänen, P Saharinen, P Gautam, MAI Keränen, ...
American Journal of Transplantation 13 (8), 2019-2034, 2013
572013
Phenotypic screening combined with machine learning for efficient identification of breast cancer-selective therapeutic targets
P Gautam, A Jaiswal, T Aittokallio, H Al-Ali, K Wennerberg
Cell chemical biology 26 (7), 970-979. e4, 2019
412019
CIP2A interacts with TopBP1 and drives basal-like breast cancer tumorigenesis
A Laine, SG Nagelli, C Farrington, U Butt, AN Cvrljevic, JP Vainonen, ...
Cancer research 81 (16), 4319-4331, 2021
372021
Concurrent inhibition of IGF1R and ERK increases pancreatic cancer sensitivity to autophagy inhibitors
CA Stalnecker, KR Grover, AC Edwards, MF Coleman, R Yang, ...
Cancer research 82 (4), 586-598, 2022
352022
Patient-tailored design for selective co-inhibition of leukemic cell subpopulations
A Ianevski, J Lahtela, KK Javarappa, P Sergeev, BR Ghimire, P Gautam, ...
Science advances 7 (8), eabe4038, 2021
322021
Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer
J Tang, P Gautam, A Gupta, L He, S Timonen, Y Akimov, W Wang, ...
NPJ systems biology and applications 5 (1), 20, 2019
322019
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