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francesco salituro
francesco salituro
Salituro MedChem Solutions
在 saliturosolutions.com 的电子邮件经过验证
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引用次数
引用次数
年份
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
F Wang, J Travins, B DeLaBarre, V Penard-Lacronique, S Schalm, ...
Science 340 (6132), 622-626, 2013
9452013
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ...
Nature chemical biology 8 (10), 839-847, 2012
7852012
AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations
K Yen, J Travins, F Wang, MD David, E Artin, K Straley, A Padyana, ...
Cancer discovery 7 (5), 478-493, 2017
4292017
Discovery of AG-120 (Ivosidenib): a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers
J Popovici-Muller, RM Lemieux, E Artin, JO Saunders, FG Salituro, ...
ACS medicinal chemistry letters 9 (4), 300-305, 2018
3932018
Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo
J Popovici-Muller, JO Saunders, FG Salituro, JM Travins, S Yan, F Zhao, ...
ACS medicinal chemistry letters 3 (10), 850-855, 2012
2442012
Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2
MP Clark, MW Ledeboer, I Davies, RA Byrn, SM Jones, E Perola, A Tsai, ...
Journal of medicinal chemistry 57 (15), 6668-6678, 2014
2222014
Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin.
MN James, A Sielecki, F Salituro, DH Rich, T Hofmann
Proceedings of the National Academy of Sciences 79 (20), 6137-6141, 1982
2211982
Small molecule activation of PKM2 in cancer cells induces serine auxotrophy
C Kung, J Hixon, S Choe, K Marks, S Gross, E Murphy, B DeLaBarre, ...
Chemistry & biology 19 (9), 1187-1198, 2012
1922012
c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo
Z Shao, K Bhattacharya, E Hsich, L Park, B Walters, U Germann, ...
Circulation research 98 (1), 111-118, 2006
1812006
Inhibitors of p38 MAP kinase: therapeutic intervention in cytokine-mediated diseases.
FG Salituro, UA Germann, KP Wilson, GW Bemis, T Fox, MS Su
Current Medicinal Chemistry 6 (9), 807-823, 1999
1561999
Pyrrolopyridines useful as inhibitors of protein kinase
M Ledeboer, M Wannamaker, L Farmer, T Wang, A Pierce, ...
US Patent 8,921,376, 2014
1542014
Activity of 5, 7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site.
BM Baron, BL Harrison, FP Miller, IA McDonald, FG Salituro, CJ Schmidt, ...
Molecular Pharmacology 38 (4), 554-561, 1990
1411990
Substituted pyrrolo [2, 3-d] pyrimidines as inhibitors of protein kinases
M Ledeboer, A Pierce, G Bemis, L Farmer, T Wang, D Messersmith, ...
US Patent 8,633,205, 2014
1222014
Inhibition of aspartic proteases by pepstatin and 3-methylstatine derivatives of pepstatin. Evidence for collected-substrate enzyme inhibition
DH Rich, MS Bernatowicz, NS Agarwal, M Kawai, FG Salituro, ...
Biochemistry 24 (13), 3165-3173, 1985
1221985
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency
C Kung, J Hixon, PA Kosinski, G Cianchetta, G Histen, Y Chen, C Hill, ...
Blood, The Journal of the American Society of Hematology 130 (11), 1347-1356, 2017
1052017
Deazapurines useful as inhibitors of Janus kinases
M Ledeboer, D Messersmith, F Maltais, H Gao, T Wang, J Cao, J Duffy, ...
US Patent 8,741,912, 2014
972014
Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
M Ledeboer, F Salituro, YC Moon
US Patent App. 10/005,133, 2002
972002
Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator
AL Althaus, MA Ackley, GM Belfort, SM Gee, J Dai, DP Nguyen, ...
Neuropharmacology 181, 108333, 2020
942020
Discovery of VX-509 (decernotinib): a potent and selective Janus kinase 3 inhibitor for the treatment of autoimmune diseases
LJ Farmer, MW Ledeboer, T Hoock, MJ Arnost, RS Bethiel, YL Bennani, ...
Journal of medicinal chemistry 58 (18), 7195-7216, 2015
942015
Diaminotriazoles useful as inhibitors of protein kinases
AC Pierce, M Amost, RJ Davies, CJ Forster, V Galullo, R Grey Jr, ...
US Patent 7,279,469, 2007
932007
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