Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements MR Mumbach, AJ Rubin, A Marson, A Kundaje, AT Satpathy, BG Gowen, ... Nature genetics 49, 1602, 2017 | 463 | 2017 |
Methods for optimizing CRISPR-Cas9 genome editing specificity J Tycko, VE Myer, PD Hsu Molecular cell 63 (3), 355-370, 2016 | 342 | 2016 |
Lessons learned from the clinical development and market authorization of Glybera LM Bryant*, DM Christopher*, AR Giles*, C Hinderer*, JL Rodriguez*, ... Human gene therapy Clinical development 24 (2), 55-64, 2013 | 271 | 2013 |
Methods and applications of CRISPR-mediated base editing in eukaryotic genomes GT Hess*, J Tycko*, D Yao*, MC Bassik Molecular cell 68 (1), 26-43, 2017 | 266 | 2017 |
Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements J Tycko*, M Wainberg*, GK Marinov*, O Ursu, GT Hess, BK Ego, A Li, ... Nature communications 10 (1), 1-14, 2019 | 112 | 2019 |
Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome MG Durrant*, A Fanton*, J Tycko*, M Hinks, SS Chandrasekaran, ... Nature Biotechnology, 1-12, 2022 | 90 | 2022 |
High-throughput discovery and characterization of human transcriptional effectors J Tycko, N DelRosso, GT Hess, A Banerjee, A Mukund, MV Van, BK Ego, ... Cell 183 (7), 2020 | 80 | 2020 |
Large-scale mapping and mutagenesis of human transcriptional effector domains N DelRosso, J Tycko, P Suzuki, C Andrews, Aradhana, A Mukund, ... Nature 616 (7956), 365-372, 2023 | 52* | 2023 |
The sound of silence: Transgene silencing in mammalian cell engineering A Cabera*, HI Edelstein*, F Glykofrydis*, KS Love*, S Palacios*, J Tycko*, ... Cell Systems 13 (12), 950-973, 2022 | 49 | 2022 |
Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells J Tycko, LA Barrera, NC Huston, AE Friedland, X Wu, JS Gootenberg, ... Nature communications 9 (1), 3542, 2018 | 36 | 2018 |
Gene drives for schistosomiasis transmission control T Maier, NJ Wheeler, EKO Namigai, J Tycko, RE Grewelle, ... PLoS neglected tropical diseases 13 (12), e0007833, 2019 | 32 | 2019 |
Identification of guide-intrinsic determinants of Cas9 specificity NC Huston, J Tycko, EL Tillotson, CJ Wilson, VE Myer, H Jayaram, ... The CRISPR journal 2 (3), 172-185, 2019 | 21 | 2019 |
Toolbox for exploring modular gene regulation in Synthetic Biology training MS Magaraci, JG Bermudez, D Yogish, DH Pak, V Mollov, J Tycko, ... ACS synthetic biology 5 (7), 781-785, 2016 | 14 | 2016 |
Large-scale discovery of recombinases for integrating DNA into the human genome MG Durrant*, A Fanton*, J Tycko*, M Hinks, SS Chandrasekaran, ... BioRxiv, 2021 | 13 | 2021 |
Advancing towards a global mammalian gene regulation model through single-cell analysis and synthetic biology J Tycko*, MV Van*, MB Elowitz, L Bintu Current Opinion in Biomedical Engineering 4, 174-193, 2017 | 13 | 2017 |
High-throughput functional characterization of combinations of transcriptional activators and repressors AX Mukund, J Tycko, SJ Allen, SA Robinson, C Andrews, J Sinha, ... Cell Systems 14 (9), 746-763. e5, 2023 | 12 | 2023 |
A genome-wide genetic screen uncovers determinants of human pigmentation VK Bajpai, T Swigut, J Mohammed, S Naqvi, M Arreola, J Tycko, TC Kim, ... Science 381 (6658), eade6289, 2023 | 11 | 2023 |
Multicenter integrated analysis of noncoding CRISPRi screens D Yao, J Tycko, JW Oh, LR Bounds, SJ Gosai, L Lataniotis, ... Nature methods 21 (4), 723-734, 2024 | 9 | 2024 |
Crispr/Cas-Related Methods and Compositions for Treating Duchenne Muscular Dystrophy and Becker PD Hsu, ML Maeder, P Odonnell, JC Tycko, NC Huston US Patent App. 15/732,190, 2019 | 9 | 2019 |
Crispr/cas-related methods and compositions for treating duchenne muscular dystrophy DA Bumcrot, NC Huston, JC Tycko, J Robinson-Hamm, CA Gersbach US Patent App. 16/098,464, 2019 | 8 | 2019 |