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Nicholas S. Akins
Nicholas S. Akins
在 emory.edu 的电子邮件经过验证
标题
引用次数
引用次数
年份
Inhibition of glycolysis and glutaminolysis: an emerging drug discovery approach to combat cancer
NS Akins, TC Nielson, HV Le
Current topics in medicinal chemistry 18 (6), 494-504, 2018
2392018
A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse
MIH Khan, BJ Sawyer, NS Akins, HV Le
European Journal of Medicinal Chemistry 243, 114785, 2022
232022
Novel GluN2B-selective NMDA receptor negative allosteric modulator possesses intrinsic analgesic properties and enhances analgesia of morphine in a rodent tail flick pain model
LD Harris, MC Regan, SJ Myers, KA Nocilla, NS Akins, YA Tahirovic, ...
ACS Chemical Neuroscience 14 (5), 917-935, 2023
72023
6, 5‐Fused Ring, C2‐Salvinorin Ester, Dual Kappa and Mu Opioid Receptor Agonists as Analgesics Devoid of Anxiogenic Effects
NS Akins, N Mishra, HM Harris, N Dudhipala, SJ Kim, AW Keasling, ...
ChemMedChem 17 (7), e202100684, 2022
72022
Kappa opioid receptors internalization is protective against oxygen-glucose deprivation through β-arrestin activation and Akt-mediated signaling pathway
J Xu, F Chen, S Wang, NS Akins, MI Hossain, Y Zhou, J Huang, J Ji, J Xi, ...
Neurochemistry international 137, 104748, 2020
62020
Alleviation of cocaine withdrawal and pertinent interactions between salvinorin-based antagonists and kappa opioid receptor
NS Akins, MF Salahuddin, P Pandey, SJ Kim, F Mahdi, MIH Khan, ...
ACS Chemical Neuroscience 14 (5), 958-976, 2023
42023
Amino-heterocycle tetrahydroisoquinoline CXCR4 antagonists with improved ADME profiles via late-stage Buchwald couplings
HH Nguyen, YA Tahirovic, VM Truax, RJ Wilson, E Jecs, EJ Miller, ...
ACS Medicinal Chemistry Letters 12 (10), 1605-1612, 2021
42021
An efficient synthetic route to l-γ-methyleneglutamine and its amide derivatives, and their selective anticancer activity
MI Hossain, AG Thomas, F Mahdi, AT Adam, NS Akins, MM Woodard, ...
RSC advances 11 (13), 7115-7128, 2021
42021
Synthesis and biological evaluation of tert-butyl ester and ethyl ester prodrugs of L-γ-methyleneglutamic acid amides for cancer
MIH Khan, F Mahdi, P Penfornis, NS Akins, MI Hossain, SJ Kim, ...
Bioorganic & medicinal chemistry 78, 117137, 2023
32023
Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles
E Jecs, YA Tahirovic, RJ Wilson, EJ Miller, M Kim, V Truax, HH Nguyen, ...
Journal of Medicinal Chemistry 65 (5), 4058-4084, 2022
32022
Allopregnanolone and neuroHIV: Potential benefits of neuroendocrine modulation in the era of antiretroviral therapy
MF Salahuddin, AN Qrareya, F Mahdi, E Moss, NS Akins, J Li, HV Le, ...
Journal of neuroendocrinology 34 (2), e13047, 2022
22022
Development of a Dihydroquinoline–Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the N-Methyl-d-aspartate Receptor
MP D’Erasmo, NS Akins, P Ma, Y Jing, SA Swanger, SK Sharma, ...
ACS Chemical Neuroscience 14 (17), 3059-3076, 2023
12023
Orally bioavailable small molecule CXCR4 antagonists with enhanced efficacy in mouse models of genitourinary cancers
EJ Miller, CQ Sun, P Gregorova, E Jecs, YA Tahirovic, RJ Wilson, ...
Cancer Research 82 (12_Supplement), 2649-2649, 2022
12022
Molecular mechanism of ligand gating and opening of NMDA receptor
TH Chou, M Epstein, RG Fritzemeier, NS Akins, S Paladugu, EZ Ullman, ...
Nature 632 (8023), 209-217, 2024
2024
Discovery of 5α-pregnan-2β, 3α-diol-20-one as a neuroHIV Protective Agent
MIH Khan, MF Salahuddin, NS Akins, F Mahdi, SJ Kim, J Li, JJ Paris, ...
2021
Development of L-γ-Methyleneglutamine-based compounds for cancer
MI Hossein, F Mahdi, MIH Khan, NS Akins, P Penfornis, SJ Kim, ...
2021
Design and Synthesis of Salvinorin-Based Compounds for the Opioid Receptors
NS Akins
The University of Mississippi, 2021
2021
Design and Development of Salvinorin-Based Ligands for Opioid Receptors
N Akins
2019
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