Inhibition of glycolysis and glutaminolysis: an emerging drug discovery approach to combat cancer NS Akins, TC Nielson, HV Le Current topics in medicinal chemistry 18 (6), 494-504, 2018 | 239 | 2018 |
A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse MIH Khan, BJ Sawyer, NS Akins, HV Le European Journal of Medicinal Chemistry 243, 114785, 2022 | 23 | 2022 |
Novel GluN2B-selective NMDA receptor negative allosteric modulator possesses intrinsic analgesic properties and enhances analgesia of morphine in a rodent tail flick pain model LD Harris, MC Regan, SJ Myers, KA Nocilla, NS Akins, YA Tahirovic, ... ACS Chemical Neuroscience 14 (5), 917-935, 2023 | 7 | 2023 |
6, 5‐Fused Ring, C2‐Salvinorin Ester, Dual Kappa and Mu Opioid Receptor Agonists as Analgesics Devoid of Anxiogenic Effects NS Akins, N Mishra, HM Harris, N Dudhipala, SJ Kim, AW Keasling, ... ChemMedChem 17 (7), e202100684, 2022 | 7 | 2022 |
Kappa opioid receptors internalization is protective against oxygen-glucose deprivation through β-arrestin activation and Akt-mediated signaling pathway J Xu, F Chen, S Wang, NS Akins, MI Hossain, Y Zhou, J Huang, J Ji, J Xi, ... Neurochemistry international 137, 104748, 2020 | 6 | 2020 |
Alleviation of cocaine withdrawal and pertinent interactions between salvinorin-based antagonists and kappa opioid receptor NS Akins, MF Salahuddin, P Pandey, SJ Kim, F Mahdi, MIH Khan, ... ACS Chemical Neuroscience 14 (5), 958-976, 2023 | 4 | 2023 |
Amino-heterocycle tetrahydroisoquinoline CXCR4 antagonists with improved ADME profiles via late-stage Buchwald couplings HH Nguyen, YA Tahirovic, VM Truax, RJ Wilson, E Jecs, EJ Miller, ... ACS Medicinal Chemistry Letters 12 (10), 1605-1612, 2021 | 4 | 2021 |
An efficient synthetic route to l-γ-methyleneglutamine and its amide derivatives, and their selective anticancer activity MI Hossain, AG Thomas, F Mahdi, AT Adam, NS Akins, MM Woodard, ... RSC advances 11 (13), 7115-7128, 2021 | 4 | 2021 |
Synthesis and biological evaluation of tert-butyl ester and ethyl ester prodrugs of L-γ-methyleneglutamic acid amides for cancer MIH Khan, F Mahdi, P Penfornis, NS Akins, MI Hossain, SJ Kim, ... Bioorganic & medicinal chemistry 78, 117137, 2023 | 3 | 2023 |
Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles E Jecs, YA Tahirovic, RJ Wilson, EJ Miller, M Kim, V Truax, HH Nguyen, ... Journal of Medicinal Chemistry 65 (5), 4058-4084, 2022 | 3 | 2022 |
Allopregnanolone and neuroHIV: Potential benefits of neuroendocrine modulation in the era of antiretroviral therapy MF Salahuddin, AN Qrareya, F Mahdi, E Moss, NS Akins, J Li, HV Le, ... Journal of neuroendocrinology 34 (2), e13047, 2022 | 2 | 2022 |
Development of a Dihydroquinoline–Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the N-Methyl-d-aspartate Receptor MP D’Erasmo, NS Akins, P Ma, Y Jing, SA Swanger, SK Sharma, ... ACS Chemical Neuroscience 14 (17), 3059-3076, 2023 | 1 | 2023 |
Orally bioavailable small molecule CXCR4 antagonists with enhanced efficacy in mouse models of genitourinary cancers EJ Miller, CQ Sun, P Gregorova, E Jecs, YA Tahirovic, RJ Wilson, ... Cancer Research 82 (12_Supplement), 2649-2649, 2022 | 1 | 2022 |
Molecular mechanism of ligand gating and opening of NMDA receptor TH Chou, M Epstein, RG Fritzemeier, NS Akins, S Paladugu, EZ Ullman, ... Nature 632 (8023), 209-217, 2024 | | 2024 |
Discovery of 5α-pregnan-2β, 3α-diol-20-one as a neuroHIV Protective Agent MIH Khan, MF Salahuddin, NS Akins, F Mahdi, SJ Kim, J Li, JJ Paris, ... | | 2021 |
Development of L-γ-Methyleneglutamine-based compounds for cancer MI Hossein, F Mahdi, MIH Khan, NS Akins, P Penfornis, SJ Kim, ... | | 2021 |
Design and Synthesis of Salvinorin-Based Compounds for the Opioid Receptors NS Akins The University of Mississippi, 2021 | | 2021 |
Design and Development of Salvinorin-Based Ligands for Opioid Receptors N Akins | | 2019 |