Bile acids activated receptors regulate innate immunity S Fiorucci, M Biagioli, A Zampella, E Distrutti Frontiers in immunology 9, 1853, 2018 | 424 | 2018 |
The bile acid receptor GPBAR1 regulates the M1/M2 phenotype of intestinal macrophages and activation of GPBAR1 rescues mice from murine colitis M Biagioli, A Carino, S Cipriani, D Francisci, S Marchianò, P Scarpelli, ... The Journal of Immunology 199 (2), 718-733, 2017 | 240 | 2017 |
Callipeltin A, an anti-HIV cyclic depsipeptide from the New Caledonian Lithistida sponge Callipelta sp. A Zampella, MV D'Auria, LG Paloma, A Casapullo, L Minale, C Debitus, ... Journal of the American Chemical Society 118 (26), 6202-6209, 1996 | 223 | 1996 |
Callipeltoside A: A Cytotoxic Aminodeoxy Sugar-Containing Macrolide of a New Type from the Marine Lithistida Sponge Callipelta sp. A Zampella, MV D'Auria, L Minale, C Debitus, C Roussakis Journal of the American Chemical Society 118 (45), 11085-11088, 1996 | 201 | 1996 |
Bile acids and their receptors in metabolic disorders S Fiorucci, E Distrutti, A Carino, A Zampella, M Biagioli Progress in Lipid Research 82, 101094, 2021 | 154 | 2021 |
Homophymine A, an Anti-HIV Cyclodepsipeptide from the Sponge Homophymia sp. A Zampella, V Sepe, P Luciano, F Bellotta, MC Monti, MV D’Auria, ... The Journal of organic chemistry 73 (14), 5319-5327, 2008 | 131 | 2008 |
Callipeltosides B and C, two novel cytotoxic glycoside macrolides from a marine lithistida sponge Callipelta sp. A Zampella, MV D'Auria, L Minale, C Debitus Tetrahedron 53 (9), 3243-3248, 1997 | 128 | 1997 |
BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis A Carino, S Cipriani, S Marchianò, M Biagioli, C Santorelli, A Donini, ... Scientific Reports 7 (1), 42801, 2017 | 119 | 2017 |
Callipeltins B and C; bioactive peptides from a marine Lithistida sponge Callipelta sp MV D'Auria, A Zampella, LG Paloma, L Minale, C Debitus, C Roussakis, ... Tetrahedron 52 (28), 9589-9596, 1996 | 106 | 1996 |
Hijacking SARS-CoV-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on the receptor binding domain A Carino, F Moraca, B Fiorillo, S Marchianò, V Sepe, M Biagioli, ... Frontiers in Chemistry 8, 572885, 2020 | 104 | 2020 |
The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation B Renga, A Mencarelli, S Cipriani, C D'Amore, A Carino, A Bruno, ... PLoS One 8 (1), e54472, 2013 | 104 | 2013 |
Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors C D’Amore, FS Di Leva, V Sepe, B Renga, C Del Gaudio, MV D’Auria, ... Journal of Medicinal Chemistry 57 (3), 937-954, 2014 | 100 | 2014 |
Farnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCA S Fiorucci, S Cipriani, A Mencarelli, F Baldelli, G Bifulco, A Zampella Mini reviews in medicinal chemistry 11 (9), 753-762, 2011 | 100 | 2011 |
Quantitative NMR-Derived Interproton Distances Combined with Quantum Mechanical Calculations of 13C Chemical Shifts in the Stereochemical Determination of … MG Chini, CR Jones, A Zampella, MV D’Auria, B Renga, S Fiorucci, ... The Journal of Organic Chemistry 77 (3), 1489-1496, 2012 | 99 | 2012 |
Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity JS Allingham, A Zampella, MV D'Auria, I Rayment Proceedings of the National Academy of Sciences 102 (41), 14527-14532, 2005 | 98 | 2005 |
Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH) S Fiorucci, M Biagioli, V Sepe, A Zampella, E Distrutti Expert Opinion on Investigational Drugs 29 (6), 623-632, 2020 | 91 | 2020 |
Role of TGR5 (GPBAR1) in liver disease V Keitel, D Häussinger Seminars in liver disease 38 (04), 333-339, 2018 | 89 | 2018 |
Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands C Festa, B Renga, C D’Amore, V Sepe, C Finamore, S De Marino, ... Journal of medicinal chemistry 57 (20), 8477-8495, 2014 | 88 | 2014 |
Farnesoid X receptor modulators 2014-present: a patent review V Sepe, E Distrutti, S Fiorucci, A Zampella Expert opinion on therapeutic patents 28 (5), 351-364, 2018 | 87 | 2018 |
Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis B Renga, A Mencarelli, C D'Amore, S Cipriani, MV D'Auria, V Sepe, ... PLoS One 7 (1), e30443, 2012 | 86 | 2012 |