How macrolide antibiotics work N Vázquez-Laslop, AS Mankin Trends in biochemical sciences 43 (9), 668-684, 2018 | 360 | 2018 |
Molecular mechanism of drug-dependent ribosome stalling N Vazquez-Laslop, C Thum, AS Mankin Molecular cell 30 (2), 190-202, 2008 | 298 | 2008 |
Increased Persistence in Escherichia coli Caused by Controlled Expression of Toxins or Other Unrelated Proteins N Vázquez-Laslop, H Lee, AA Neyfakh Journal of bacteriology 188 (10), 3494-3497, 2006 | 292 | 2006 |
A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates. M Ahmed, CM Borsch, SS Taylor, N Vazquez-Laslop, AA Neyfakh Journal of Biological Chemistry 269 (45), 28506-28513, 1994 | 259 | 1994 |
Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated M Ahmed, L Lyass, PN Markham, SS Taylor, N Vazquez-Laslop, ... Journal of bacteriology 177 (14), 3904-3910, 1995 | 237 | 1995 |
Programmed drug‐dependent ribosome stalling H Ramu, A Mankin, N Vazquez‐Laslop Molecular microbiology 71 (4), 811-824, 2009 | 181 | 2009 |
The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide N Vázquez‐Laslop, H Ramu, D Klepacki, K Kannan, AS Mankin The EMBO journal 29 (18), 3108-3117, 2010 | 174 | 2010 |
Selective protein synthesis by ribosomes with a drug-obstructed exit tunnel K Kannan, N Vázquez-Laslop, AS Mankin Cell 151 (3), 508-520, 2012 | 172 | 2012 |
Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center J Marks, K Kannan, EJ Roncase, D Klepacki, A Kefi, C Orelle, ... Proceedings of the National Academy of Sciences 113 (43), 12150-12155, 2016 | 164 | 2016 |
An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome T Florin, C Maracci, M Graf, P Karki, D Klepacki, O Berninghausen, ... Nature structural & molecular biology 24 (9), 752-757, 2017 | 163 | 2017 |
Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide S Arenz, H Ramu, P Gupta, O Berninghausen, R Beckmann, ... Nature communications 5 (1), 3501, 2014 | 161 | 2014 |
Retapamulin-assisted ribosome profiling reveals the alternative bacterial proteome S Meydan, J Marks, D Klepacki, V Sharma, PV Baranov, AE Firth, ... Molecular cell 74 (3), 481-493. e6, 2019 | 155 | 2019 |
Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase center H Ramu, N Vázquez-Laslop, D Klepacki, Q Dai, J Piccirilli, R Micura, ... Molecular cell 41 (3), 321-330, 2011 | 144 | 2011 |
Molecular Sieve Mechanism of Selective Release of Cytoplasmic Proteins by Osmotically Shocked Escherichia coli N Vázquez-Laslop, H Lee, R Hu, AA Neyfakh Journal of Bacteriology 183 (8), 2399-2404, 2001 | 129 | 2001 |
Macrolide antibiotics allosterically predispose the ribosome for translation arrest S Sothiselvam, B Liu, W Han, H Ramu, D Klepacki, GC Atkinson, A Brauer, ... Proceedings of the National Academy of Sciences 111 (27), 9804-9809, 2014 | 127 | 2014 |
Drug sensing by the ribosome induces translational arrest via active site perturbation S Arenz, S Meydan, AL Starosta, O Berninghausen, R Beckmann, ... Molecular cell 56 (3), 446-452, 2014 | 124 | 2014 |
Efflux of the natural polyamine spermidine facilitated by the Bacillus subtilis multidrug transporter Blt DP Woolridge, N Vazquez-Laslop, PN Markham, MS Chevalier, ... Journal of Biological Chemistry 272 (14), 8864-8866, 1997 | 122 | 1997 |
Programmed ribosomal frameshifting generates a copper transporter and a copper chaperone from the same gene S Meydan, D Klepacki, S Karthikeyan, T Margus, P Thomas, JE Jones, ... Molecular cell 65 (2), 207-219, 2017 | 96 | 2017 |
Regulation of gene expression by macrolide-induced ribosomal frameshifting P Gupta, K Kannan, AS Mankin, N Vázquez-Laslop Molecular cell 52 (5), 629-642, 2013 | 77 | 2013 |
Deregulation of translation due to post-transcriptional modification of rRNA explains why erm genes are inducible P Gupta, S Sothiselvam, N Vázquez-Laslop, AS Mankin Nature communications 4 (1), 1984, 2013 | 75 | 2013 |