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Sean Chia
Sean Chia
Bioprocessing Technology Institute, A*STAR
在 bti.a-star.edu.sg 的电子邮件经过验证
标题
引用次数
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年份
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, ...
Science advances 2 (2), e1501244, 2016
2252016
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, ...
Nature chemistry 10 (6), 673-683, 2018
2232018
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, ...
Proceedings of the National Academy of Sciences 114 (2), E200-E208, 2017
2142017
Chemical kinetics for bridging molecular mechanisms and macroscopic measurements of amyloid fibril formation
TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, ...
Annual review of physical chemistry 69 (1), 273-298, 2018
2022018
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ...
Nature communications 10 (1), 225, 2019
1422019
SAR by kinetics for drug discovery in protein misfolding diseases
S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, ...
Proceedings of the National Academy of Sciences 115 (41), 10245-10250, 2018
662018
Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers
FS Ruggeri, J Habchi, S Chia, RI Horne, M Vendruscolo, TPJ Knowles
Nature Communications 12 (1), 688, 2021
642021
Transthyretin inhibits primary and secondary nucleations of amyloid-β peptide aggregation and reduces the toxicity of its oligomers
SA Ghadami, S Chia, FS Ruggeri, G Meisl, F Bemporad, J Habchi, ...
Biomacromolecules 21 (3), 1112-1125, 2020
632020
Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates
S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, ...
Proceedings of the National Academy of Sciences 114 (30), 8005-8010, 2017
602017
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, ...
Communications biology 3 (1), 435, 2020
552020
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity
FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, ...
Nature communications 9 (1), 1-12, 2018
502018
Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions
B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, ...
ACS chemical neuroscience 9 (12), 2959-2971, 2018
492018
Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers
R Limbocker, R Staats, S Chia, FS Ruggeri, B Mannini, CK Xu, M Perni, ...
Frontiers in Neuroscience 15, 680026, 2021
432021
A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
R Cataldi, S Chia, K Pisani, FS Ruggeri, CK Xu, T Šneideris, M Perni, ...
Communications Biology 4 (1), 19, 2021
402021
A fragment-based method of creating small-molecule libraries to target the aggregation of intrinsically disordered proteins
P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo
ACS combinatorial science 18 (3), 144-153, 2016
402016
Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
R Staats, TCT Michaels, P Flagmeier, S Chia, RI Horne, J Habchi, S Linse, ...
Communications Chemistry 3 (1), 191, 2020
362020
Surface-catalyzed secondary nucleation dominates the generation of toxic IAPP aggregates
DC Rodriguez Camargo, S Chia, J Menzies, B Mannini, G Meisl, ...
Frontiers in Molecular Biosciences 8, 757425, 2021
282021
Structure-based discovery of small-molecule inhibitors of the autocatalytic proliferation of α-Synuclein aggregates
S Chia, Z Faidon Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, ...
Molecular Pharmaceutics 20 (1), 183-193, 2022
272022
Proliferation of tau 304–380 fragment aggregates through autocatalytic secondary nucleation
DC Rodriguez Camargo, E Sileikis, S Chia, E Axell, K Bernfur, RL Cataldi, ...
ACS Chemical Neuroscience 12 (23), 4406-4415, 2021
262021
Complexity in Lipid Membrane Composition Induces Resilience to Aβ42 Aggregation
M Sanguanini, KN Baumann, S Preet, S Chia, J Habchi, TPJ Knowles, ...
ACS chemical neuroscience 11 (9), 1347-1352, 2020
252020
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