Senescence surveillance of pre-malignant hepatocytes limits liver cancer development TW Kang, T Yevsa, N Woller, L Hoenicke, T Wuestefeld, D Dauch, ... Nature 479 (7374), 547-551, 2011 | 1576 | 2011 |
Microglia emerge from erythromyeloid precursors via Pu. 1-and Irf8-dependent pathways K Kierdorf, D Erny, T Goldmann, V Sander, C Schulz, EG Perdiguero, ... Nature neuroscience 16 (3), 273-280, 2013 | 1549 | 2013 |
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions A Mildner, H Schmidt, M Nitsche, D Merkler, UK Hanisch, M Mack, ... Nature neuroscience 10 (12), 1544-1553, 2007 | 1199 | 2007 |
From NASH to HCC: current concepts and future challenges QM Anstee, HL Reeves, E Kotsiliti, O Govaere, M Heikenwalder Nature reviews Gastroenterology & hepatology 16 (7), 411-428, 2019 | 1142 | 2019 |
The maternal microbiota drives early postnatal innate immune development M Gomez de Agüero, SC Ganal-Vonarburg, T Fuhrer, S Rupp, ... Science 351 (6279), 1296-1302, 2016 | 1087 | 2016 |
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA J Lucifora, Y Xia, F Reisinger, K Zhang, D Stadler, X Cheng, MF Sprinzl, ... Science 343 (6176), 1221-1228, 2014 | 1036 | 2014 |
Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses S Hapfelmeier, MAE Lawson, E Slack, JK Kirundi, M Stoel, ... Science 328 (5986), 1705-1709, 2010 | 876 | 2010 |
Immunotherapies for hepatocellular carcinoma JM Llovet, F Castet, M Heikenwalder, MK Maini, V Mazzaferro, DJ Pinato, ... Nature reviews Clinical oncology 19 (3), 151-172, 2022 | 871 | 2022 |
The immunology of hepatocellular carcinoma M Ringelhan, D Pfister, T O’Connor, E Pikarsky, M Heikenwalder Nature immunology 19 (3), 222-232, 2018 | 862 | 2018 |
NASH limits anti-tumour surveillance in immunotherapy-treated HCC D Pfister, NG Núñez, R Pinyol, O Govaere, M Pinter, M Szydlowska, ... Nature 592 (7854), 450-456, 2021 | 817 | 2021 |
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype N Herranz, S Gallage, M Mellone, T Wuestefeld, S Klotz, CJ Hanley, ... Nature cell biology 17 (9), 1205-1217, 2015 | 688 | 2015 |
Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes MJ Wolf, A Adili, K Piotrowitz, Z Abdullah, Y Boege, K Stemmer, ... Cancer cell 26 (4), 549-564, 2014 | 673 | 2014 |
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation T Goldmann, P Wieghofer, PF Müller, Y Wolf, D Varol, S Yona, ... Nature neuroscience 16 (11), 1618-1626, 2013 | 665 | 2013 |
Peripherally applied Aβ-containing inoculates induce cerebral β-amyloidosis YS Eisele, U Obermüller, G Heilbronner, F Baumann, SA Kaeser, ... Science 330 (6006), 980-982, 2010 | 660 | 2010 |
NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis C Ma, AH Kesarwala, T Eggert, J Medina-Echeverz, DE Kleiner, P Jin, ... Nature 531 (7593), 253-257, 2016 | 647 | 2016 |
Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration M Heikenwalder, M Polymenidou, T Junt, C Sigurdson, H Wagner, S Akira, ... Nature medicine 10 (2), 187-192, 2004 | 549 | 2004 |
Distinct functions of senescence-associated immune responses in liver tumor surveillance and tumor progression T Eggert, K Wolter, J Ji, C Ma, T Yevsa, S Klotz, J Medina-Echeverz, ... Cancer cell 30 (4), 533-547, 2016 | 500 | 2016 |
Molecular mechanisms of prion pathogenesis A Aguzzi, C Sigurdson, M Heikenwaelder Annu. Rev. Pathol. Mech. Dis. 3, 11-40, 2008 | 447 | 2008 |
A lymphotoxin-driven pathway to hepatocellular carcinoma J Haybaeck, N Zeller, MJ Wolf, A Weber, U Wagner, MO Kurrer, J Bremer, ... Cancer cell 16 (4), 295-308, 2009 | 443 | 2009 |
The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88 … S Hapfelmeier, B Stecher, M Barthel, M Kremer, AJ Muller, ... The Journal of Immunology 174 (3), 1675-1685, 2005 | 426 | 2005 |