Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors SA Moghadasi, E Heilmann, AM Khalil, C Nnabuife, FL Kearns, C Ye, ... Science advances 9 (13), eade8778, 2023 | 91 | 2023 |
SARS-CoV-2 3CLpro mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376 E Heilmann, F Costacurta, SA Moghadasi, C Ye, M Pavan, D Bassani, ... Science translational medicine 15 (678), eabq7360, 2022 | 71 | 2022 |
HIV-1 Vif triggers cell cycle arrest by degrading cellular PPP2R5 phospho-regulators DJ Salamango, T Ikeda, SA Moghadasi, J Wang, JL McCann, ... Cell reports 29 (5), 1057-1065. e4, 2019 | 40 | 2019 |
Evolution-guided structural and functional analyses of the HERC family reveal an ancient marine origin and determinants of antiviral activity E Paparisto, MW Woods, MD Coleman, SA Moghadasi, DS Kochar, ... Journal of virology 92 (13), 10.1128/jvi. 00528-18, 2018 | 32 | 2018 |
Natural APOBEC3C variants can elicit differential HIV-1 restriction activity BD Anderson, T Ikeda, SA Moghadasi, AS Martin, WL Brown, RS Harris Retrovirology 15, 1-11, 2018 | 28 | 2018 |
Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 Mpro/3CLpro in Living Cells SA Moghadasi, MA Esler, Y Otsuka, JT Becker, SN Moraes, CB Anderson, ... MBio 13 (3), e00784-22, 2022 | 18 | 2022 |
A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition E Heilmann, F Costacurta, S Geley, SA Mogadashi, A Volland, B Rupp, ... Communications Biology 5 (1), 391, 2022 | 13 | 2022 |
Rapid resistance profiling of SARS-CoV-2 protease inhibitors SA Moghadasi, RG Biswas, DA Harki, RS Harris npj Antimicrobials and Resistance 1 (1), 9, 2023 | 11 | 2023 |
Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases SN Moraes, JT Becker, SA Moghadasi, NM Shaban, AA Auerbach, ... elife 11, e83893, 2022 | 7 | 2022 |
SARS-CoV-2 3CL (pro) mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376. Sci Transl Med 15: eabq7360 E Heilmann, F Costacurta, SA Moghadasi, C Ye, M Pavan, D Bassani, ... | 6 | 2022 |
DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors R Jimmidi, S Chamakuri, S Lu, MN Ucisik, PJ Chen, KM Bohren, ... Communications Chemistry 6 (1), 164, 2023 | 3 | 2023 |
Ancestral APOBEC3B nuclear localization is maintained in humans and apes and altered in most other Old World primate species AA Auerbach, JT Becker, SN Moraes, SA Moghadasi, JM Duda, ... Msphere 7 (6), e00451-22, 2022 | 3 | 2022 |
Mitochondrial double-stranded RNA triggers induction of the antiviral DNA deaminase APOBEC3A and nuclear DNA damage C Wick, SA Moghadasi, JT Becker, E Fanunza, S Oh, E Bournique, ... Journal of Biological Chemistry 299 (9), 2023 | 2 | 2023 |
A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system F Costacurta, A Dodaro, D Bante, H Schöppe, B Sprenger, SA Moghadasi, ... bioRxiv, 2023 | 1 | 2023 |
Abstract 1217 SARS-CoV-2 Main Protease Inhibitor High-Throughput Screen R Delgado, J Vishwakarma, S Moghadasi, Y Otsuka, L Scampavia, ... Journal of Biological Chemistry 300 (3), 2024 | | 2024 |
Live cell assay for protease inhibition RS Harris, SA Moghadasi, J Becker US Patent App. 18/035,021, 2024 | | 2024 |
Highly Specific Sars-Cov-2 Main Protease (Mpro) Mutations Against the Clinical Antiviral Ensitrelvir Selected in a Safe, Vsv-Based System S Rauch, H Schöppe, D Bante, F Costacurta, SA Moghadasi, L Krismer, ... Vsv-Based System (January 6, 2024), 2024 | | 2024 |
Cellular Assays for Dynamic Quantification of Deubiquitinase Activity and Inhibition SA Moghadasi, SN Moraes, RS Harris Journal of Molecular Biology 435 (23), 168316, 2023 | | 2023 |
Rapid resistance profiling of SARS-CoV-2 protease inhibitors (preprint) SA Moghadasi, R Biswas, DA Harki, R Harris | | 2023 |
A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system (preprint) F Costacurta, A Dodaro, D Bante, H Schoeppe, B Sprenger, ... | | 2023 |