| Phosphorylation regulates intracellular trafficking of β-secretase J Walter, R Fluhrer, B Hartung, M Willem, C Kaether, A Capell, S Lammich, ... Journal of Biological Chemistry 276 (18), 14634-14641, 2001 | 380 | 2001 |
| Intramembrane proteolysis by γ-secretase H Steiner, R Fluhrer, C Haass Journal of Biological Chemistry 283 (44), 29627-29631, 2008 | 286 | 2008 |
| Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments SF Lichtenthaler, MK Lemberg, R Fluhrer The EMBO journal 37 (15), e99456, 2018 | 281 | 2018 |
| Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b L Martin, R Fluhrer, K Reiss, E Kremmer, P Saftig, C Haass Journal of Biological Chemistry 283 (3), 1644-1652, 2008 | 204 | 2008 |
| Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases M Voss, B Schröder, R Fluhrer Biochimica et Biophysica Acta (BBA)-Biomembranes 1828 (12), 2828-2839, 2013 | 182 | 2013 |
| A γ-secretase-like intramembrane cleavage of TNFα by the GxGD aspartyl protease SPPL2b R Fluhrer, G Grammer, L Israel, MM Condron, C Haffner, E Friedmann, ... Nature cell biology 8 (8), 894-896, 2006 | 180 | 2006 |
| A non‐amyloidogenic function of BACE‐2 in the secretory pathway R Fluhrer, A Capell, G Westmeyer, M Willem, B Hartung, MM Condron, ... Journal of neurochemistry 81 (5), 1011-1020, 2002 | 155 | 2002 |
| Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of γ-secretase-mediated intramembrane proteolysis A Fukumori, R Fluhrer, H Steiner, C Haass Journal of Neuroscience 30 (23), 7853-7862, 2010 | 132 | 2010 |
| The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain J Schneppenheim, R Dressel, S Hüttl, R Lüllmann-Rauch, M Engelke, ... Journal of Experimental Medicine 210 (1), 41-58, 2013 | 126 | 2013 |
| Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3 P Krawitz, C Haffner, R Fluhrer, H Steiner, B Schmid, C Haass Journal of Biological Chemistry 280 (47), 39515-39523, 2005 | 124 | 2005 |
| Shedding of glycan‐modifying enzymes by signal peptide peptidase‐like 3 (SPPL 3) regulates cellular N‐glycosylation M Voss, U Künzel, F Higel, PH Kuhn, A Colombo, A Fukumori, ... The EMBO journal 33 (24), 2890-2905, 2014 | 114 | 2014 |
| Apical sorting of β-secretase limits amyloid β-peptide production A Capell, L Meyn, R Fluhrer, DB Teplow, J Walter, C Haass Journal of Biological Chemistry 277 (7), 5637-5643, 2002 | 106 | 2002 |
| Secretome Analysis Identifies Novel Signal Peptide Peptidase-Like 3 (SPPL3) Substrates and Reveals a Role of SPPL3 in Multiple Golgi Glycosylation Pathways*[S] PH Kuhn, M Voss, M Haug-Kröper, B Schröder, U Schepers, S Bräse, ... Molecular & Cellular Proteomics 14 (6), 1584-1598, 2015 | 98 | 2015 |
| Identification of a β-secretase activity, which truncates amyloid β-peptide after its presenilin-dependent generation R Fluhrer, G Multhaup, A Schlicksupp, M Okochi, M Takeda, S Lammich, ... Journal of Biological Chemistry 278 (8), 5531-5538, 2003 | 98 | 2003 |
| Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases R Fluhrer, H Steiner, C Haass Journal of Biological Chemistry 284 (21), 13975-13979, 2009 | 93 | 2009 |
| Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process F Kamp, E Winkler, J Trambauer, A Ebke, R Fluhrer, H Steiner Biophysical journal 108 (5), 1229-1237, 2015 | 81 | 2015 |
| Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis R Fluhrer, A Friedlein, C Haass, J Walter Journal of Biological Chemistry 279 (3), 1585-1593, 2004 | 80 | 2004 |
| Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis L Martin, R Fluhrer, C Haass Journal of Biological Chemistry 284 (9), 5662-5670, 2009 | 73 | 2009 |
| Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3) M Voss, A Fukumori, PH Kuhn, U Künzel, B Klier, G Grammer, ... Journal of Biological Chemistry 287 (52), 43401-43409, 2012 | 54 | 2012 |
| Proteolytic processing of neuregulin 1 type III by three intramembrane-cleaving proteases D Fleck, M Voss, B Brankatschk, C Giudici, H Hampel, B Schwenk, ... Journal of Biological Chemistry 291 (1), 318-333, 2016 | 53 | 2016 |
