Salmonella takes control: effector-driven manipulation of the host EJ McGhie, LC Brawn, PJ Hume, D Humphreys, V Koronakis Current opinion in microbiology 12 (1), 117-124, 2009 | 441 | 2009 |
Transition to the open state of the TolC periplasmic tunnel entrance C Andersen, E Koronakis, E Bokma, J Eswaran, D Humphreys, C Hughes, ... Proceedings of the National Academy of Sciences 99 (17), 11103-11108, 2002 | 212 | 2002 |
WAVE regulatory complex activation by cooperating GTPases Arf and Rac1 V Koronakis, PJ Hume, D Humphreys, T Liu, O Hørning, ON Jensen, ... Proceedings of the National Academy of Sciences 108 (35), 14449-14454, 2011 | 163 | 2011 |
Salmonella virulence effector SopE and Host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion D Humphreys, A Davidson, PJ Hume, V Koronakis Cell host & microbe 11 (2), 129-139, 2012 | 108 | 2012 |
Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells D Humphreys, AC Davidson, PJ Hume, LE Makin, V Koronakis Proceedings of the National Academy of Sciences 110 (42), 16880-16885, 2013 | 103 | 2013 |
The Salmonella effector SptP dephosphorylates host AAA+ ATPase VCP to promote development of its intracellular replicative niche D Humphreys, PJ Hume, V Koronakis Cell host & microbe 5 (3), 225-233, 2009 | 99 | 2009 |
Enteropathogenic Escherichia coli recruits the cellular inositol phosphatase SHIP2 to regulate actin-pedestal formation K Smith, D Humphreys, PJ Hume, V Koronakis Cell host & microbe 7 (1), 13-24, 2010 | 77 | 2010 |
Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection AEM Ibler, M ElGhazaly, KL Naylor, NA Bulgakova, S F. El-Khamisy, ... Nature Communications 10 (1), 4040, 2019 | 52 | 2019 |
Nucleotide binding by Lhs1p is essential for its nucleotide exchange activity and for function in vivo J de Keyzer, GJ Steel, SJ Hale, D Humphries, CJ Stirling Journal of Biological Chemistry 284 (46), 31564-31571, 2009 | 49 | 2009 |
Arf GTPase interplay with Rho GTPases in regulation of the actin cytoskeleton V Singh, AC Davidson, PJ Hume, D Humphreys, V Koronakis Small GTPases 10 (6), 411-418, 2019 | 42 | 2019 |
MYO6 is targeted by Salmonella virulence effectors to trigger PI3-kinase signaling and pathogen invasion into host cells ABE Brooks, D Humphreys, V Singh, AC Davidson, SD Arden, F Buss, ... Proceedings of the National Academy of Sciences 114 (15), 3915-3920, 2017 | 37 | 2017 |
Senescence and host–pathogen interactions D Humphreys, M ElGhazaly, T Frisan Cells 9 (7), 1747, 2020 | 35 | 2020 |
Inhibition of WAVE regulatory complex activation by a bacterial virulence effector counteracts pathogen phagocytosis D Humphreys, V Singh, V Koronakis Cell reports 17 (3), 697-707, 2016 | 35 | 2016 |
The Arf GTPase-activating protein family is exploited by Salmonella enterica serovar Typhimurium to invade nonphagocytic host cells AC Davidson, D Humphreys, ABE Brooks, PJ Hume, V Koronakis MBio 6 (1), 10.1128/mbio. 02253-14, 2015 | 33 | 2015 |
Clustering transfers the translocated Escherichia coli receptor into lipid rafts to stimulate reversible activation of c‐Fyn RD Hayward, PJ Hume, D Humphreys, N Phillips, K Smith, V Koronakis Cellular microbiology 11 (3), 433-441, 2009 | 31 | 2009 |
The Drosophila Arf1 homologue Arf79F is essential for lamellipodium formation D Humphreys, T Liu, AC Davidson, PJ Hume, V Koronakis Journal of cell science 125 (23), 5630-5635, 2012 | 26 | 2012 |
Sequence divergence in type III secretion gene clusters of the Burkholderia cepacia complex KJ Glendinning, YN Parsons, K Duangsonk, BA Hales, D Humphreys, ... FEMS microbiology letters 235 (2), 229-235, 2004 | 20 | 2004 |
WAVE regulatory complex activation PJ Hume, D Humphreys, V Koronakis Methods in Enzymology 540, 363-379, 2014 | 16 | 2014 |
Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection M ElGhazaly, MO Collins, AEM Ibler, D Humphreys Cell Reports 42 (10), 2023 | 3 | 2023 |
London calling: The 5th UK Cellular Microbiology Network Meeting S Mostowy, C Odendall, D Humphreys, PM Elks, JL Rohn Molecular Microbiology, 2023 | | 2023 |